Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
Single Dose Morphine and Fentanyl Added to Intrathecal Mixture on Orthopedics Patients With Undiagnosed Obstructive Sleep Apnea
- First Posted Date
- 2013-12-18
- Last Posted Date
- 2013-12-19
- Lead Sponsor
- University of Malaya
- Target Recruit Count
- 40
- Registration Number
- NCT02014714
- Locations
- 🇲🇾
University Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose
- Conditions
- Interventions
- First Posted Date
- 2013-12-12
- Last Posted Date
- 2016-07-25
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 84
- Registration Number
- NCT02009722
- Locations
- 🇺🇸
Rochester Methodist Hospital, Mayo Clinic, Rochester, Minnesota, United States
Impact of Epidural Morphine on Shoulder Pain Following Thoracotomy.
- Conditions
- Interventions
- First Posted Date
- 2013-11-14
- Last Posted Date
- 2014-05-12
- Target Recruit Count
- 22
- Registration Number
- NCT01984463
- Locations
- 🇨🇦
Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada
Incidence of Headache Following an Unintentional Dural Puncture
- Conditions
- Interventions
- First Posted Date
- 2013-11-07
- Last Posted Date
- 2021-11-17
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 68
- Registration Number
- NCT01977898
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
First Evaluation of Morphine Hydrochloride by Nebulisation in Healthy Volunteers
- First Posted Date
- 2013-11-05
- Last Posted Date
- 2019-10-24
- Lead Sponsor
- University Hospital, Rouen
- Target Recruit Count
- 35
- Registration Number
- NCT01975753
- Locations
- 🇫🇷
University Hospital, Rouen, Haute Normandie, France
Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-10-21
- Last Posted Date
- 2013-10-21
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 180
- Registration Number
- NCT01966172
- Locations
- 🇩🇰
Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-10-01
- Last Posted Date
- 2015-10-27
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 160
- Registration Number
- NCT01953978
- Locations
- 🇩🇰
Glostrup University Hospital, Glostrup, Denmark
Sub-dissociative Ketamine for the Management of Acute Pediatric Pain
- First Posted Date
- 2013-09-27
- Last Posted Date
- 2018-07-03
- Lead Sponsor
- HealthPartners Institute
- Target Recruit Count
- 77
- Registration Number
- NCT01951963
- Locations
- 🇺🇸
Regions Hospital, Saint Paul, Minnesota, United States
Prospective Longitudinal Observational Study to Evaluate the Clinical Characteristics and Opioids Treatments in Patients With Breakthrough Cancer Pain
- First Posted Date
- 2013-09-19
- Last Posted Date
- 2016-04-14
- Target Recruit Count
- 150
- Registration Number
- NCT01946555
- Locations
- 🇮🇹
A.O. Universitaria Parma, Parma, Italia, Italy
🇮🇹Ospedale di Piacenza, Piacenza, Italy
🇮🇹Ospedale Magati, Scandiano, Italia, Italy
Evaluation of Preoperative Use of Pregabalin on Postoperative Analgesia After Laparoscopic Colorectal Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-09-12
- Last Posted Date
- 2019-02-27
- Lead Sponsor
- Larissa University Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT01940224
- Locations
- 🇬🇷
University Hospital of Larissa, Larissa, Greece
Drug Development Updates
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