Ibuprofen

Brand Names: Addaprin, Advil, Advil Cold and Sinus, Advil Congestion Relief, Advil PM, Advil Sinus Congestion and Pain, Alivio, Caldolor, Cedaprin, Children's Ibuprofen, Diphen, Duexis, Ibu, Ibutab, Junior Strength Motrin, Motrin, Motrin PM, Neoprofen, Nuprin, Pedea, Proprinal, Reprexain, Sudafed PE Head Congestion Plus Pain, Vicoprofen, Wal-profen Congestion Relief and Pain, Ibuprofen Gen.Orph

Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.

On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.

Indication: Ibuprofen is the most commonly used and prescribed NSAID. It is a very common over-the-counter medication widely used as an analgesic, anti-inflammatory and antipyretic.

The use of ibuprofen and its enantiomer Dexibuprofen in a racemic mix is common for the management of mild to moderate pain related to dysmenorrhea, headache, migraine, postoperative dental pain, spondylitis, osteoarthritis, rheumatoid arthritis, and soft tissue disorder.

Due to its activity against prostaglandin and thromboxane synthesis, ibuprofen has been attributed to alteration of platelet function and prolongation of gestation and labour.

As ibuprofen is a widely used medication, the main therapeutic indications are:

Associated Conditions: Acute Pain, Ankylosing Spondylitis (AS), Common Cold, Cystic Fibrosis (CF), Fever, Gastric Ulcer, Gout, Headache, Insomnia, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Migraine, Mild pain, Nasal Congestion, Osteoarthritis (OA), Pain, Pain, Inflammatory, Patent Ductus Arteriosus (PDA), Pericarditis, Primary Dysmenorrhoea, Rheumatoid Arthritis, Severe Pain, Sinus pressure, Mild to moderate pain, Minor aches and pains, Moderate Pain

Treatment of Orthostatic Hypotension in Autonomic Failure

Phase 1

Completed

Interventions: Drug: Atomoxetine
Drug: placebo
Drug: Acarbose
Device: inflatable abdominal binder (sham)
Drug: Pyridostigmine Bromide
Drug: Yohimbine
Drug: Midodrine HCl
Drug: Modafinil
Drug: Octreotide
Other: water intake
Drug: Diphenhydramine Hydrochloride
Drug: Ranitidine HCL
Drug: Tranylcypromine
Drug: Ergotamine/ Caffeine
Drug: Celecoxib
Drug: Pseudoephedrine
Drug: Methylphenidate
Drug: Indomethacin
Drug: Ibuprofen
Drug: Oxymetazoline 0.05% nasal solution
Dietary Supplement: Bovril
Drug: Acetazolamide
Drug: Rivastigmine tartrate
Drug: Carbidopa/levodopa
Device: Inflatable abdominal binder

Phase 4

Completed

Locations: 🇫🇷
CHU, Dijon, France
🇫🇷
AP-HM (Néonatologie), Marseille, France
🇫🇷
Maternite Regionale Universitaire, Nancy, France

Not Applicable

Completed

Locations: 🇺🇸
Washington University - St. Louis Children's Hospital, St. Louis, Missouri, United States
🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸
University of California - San Diego, San Diego, California, United States