Glucose

Generic Name: Glucose

Brand Names: Bss Ophthalmic Solution, Citrasate, Clinimix 2.75/5, Clinimix E 2.75/5, Dextroject, Dianeal, H.E.L.P.bicel, Hemosate Ultra, Lactate 1-2-3, Leukotrap, Naturalyte, Nauzene, Normosol-R, Nxstage Pureflow, Olimel, Periolimel, Physioneal 40, Sag-M, Sclerodex, Selectbag One

Drug Type: Small Molecule

Unique Ingredient Identifier: IY9XDZ35W2

Background: Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. It is primarily stored as starch in plants and glycogen in animals to be used in various metabolic processes in the cellular level. Its aldohexose stereoisomer, dextrose or D-glucose, is the most commonly occurring isomer of glucose in nature. L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative. The unspecified form of glucose is commonly supplied as an injection for nutritional supplementation or metabolic disorders where glucose levels are improperly regulated. Glucose is listed on the World Health Organization's List of Essential Medicines.

Indication: Glucose pharmaceutical formulations (oral tablets, injections) are indicated for caloric supply and carbohydrate supplementation in case of nutrient deprivation. It is also used in metabolic disorders such as hypoglycemia.

Associated Conditions: Arrhythmia, Caloric Deficit, Edema of the cerebrum, Hypoglycemia, Metabolic Alkalosis

Associated Therapies: Blood Specimen Collection, Electrolyte replacement, Nutritional supplementation, Parenteral Nutrition, Parenteral rehydration therapy, Plasmapheresis, Positive cardiac inotropic effect, Total parenteral nutrition therapy, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy

Clinical Trials

Comparison of the Efficacy of Prolotherapy Injection Therapy & Local Anesthetic Injection Therapy.

Not Applicable

Completed

Conditions: Myofascial Pain Syndrome of Neck

Interventions: Drug: Lidocain
Drug: Dextrose solution

First Posted Date: 2022-02-14

Last Posted Date: 2023-12-13

Lead Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Target Recruit Count: 28

Registration Number: NCT05239091

Locations: 🇹🇷
Istanbul Physical Medicine Rehabilitation Hospital, Istanbul, Turkey

Clinical Efficacy of Megadose Vitamin C in Sepsis

Phase 2

Recruiting

Conditions: Septic Shock
Sepsis

Interventions: Drug: 5% glucose injection
Drug: Vitamin C

First Posted Date: 2022-01-18

Last Posted Date: 2024-03-19

Lead Sponsor: Zhujiang Hospital

Target Recruit Count: 234

Registration Number: NCT05194189

Locations: 🇨🇳
Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University, Guanzhou, Guangdong, China
🇨🇳
Department of Critical Care Medicine of Zhongshan People's Hospital, Zhongshan, Guangzhou, China
🇨🇳
Department of Critical Care Medicine of Yunfu People's Hospital, Yunfu, Guangdong, China

and more 1 locations

Intraarticular Dextrose Prolotherapy for Symptomatic Knee Osteoarthritis

Phase 2

Active, not recruiting

Conditions: Knee Osteoarthritis

Interventions: Drug: Placebo
Drug: Dextrose prolotherapy (DPT)

First Posted Date: 2021-12-16

Last Posted Date: 2024-10-17

Lead Sponsor: Mayo Clinic

Target Recruit Count: 160

Registration Number: NCT05160532

Locations: 🇺🇸
Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Prolotherapy Intervention in Patient With Frozen Shoulder

Phase 4

Completed

Conditions: Frozen Shoulder

Interventions: Drug: Normal Saline 20 mL Injection
Drug: Dextrose 15 % in Water

First Posted Date: 2021-11-23

Last Posted Date: 2022-12-22

Lead Sponsor: Bumi Herman

Target Recruit Count: 32

Registration Number: NCT05131269

Locations: 🇮🇩
Hasanuddin University, Faculty of Medicine, Makassar, South Sulawesi, Indonesia

Effect of Using Dextrose-containing Intraoperative Fluid in Children

Not Applicable

Conditions: Pediatric Surgery

Interventions: Drug: Ringer acetate
Drug: Dextrose 5
Drug: 1.25%Dextrose equivalence
Drug: 2.5%Dextrose equivalence

First Posted Date: 2021-09-30

Last Posted Date: 2021-09-30

Lead Sponsor: Mahidol University

Target Recruit Count: 68

Registration Number: NCT05061836

Locations: 🇹🇭
Siriraj Hospital, Bangkok noi, Bangkok, Thailand

High-dose Intravenous Vitamin C (HDIVC) as Adjuvant Therapy in Critical Patients With Positive COVID-19. A Pilot Randomized Controlled Dose-comparison Trial.

Phase 3

Conditions: Covid19

Interventions: Drug: Dextrose 500 mL
Drug: High doses of intravenous vitamin C

First Posted Date: 2021-08-31

Last Posted Date: 2021-08-31

Lead Sponsor: Hugo Galindo

Target Recruit Count: 160

Registration Number: NCT05029037

Sodium Nitroprusside in Early Course Schizophrenia

Phase 2

Terminated

Conditions: Schizophrenia
Schizoaffective Disorder

Interventions: Drug: 5% Dextrose solution
Drug: Sodium Nitroprusside

First Posted Date: 2021-08-02

Last Posted Date: 2024-08-12

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 1

Registration Number: NCT04986072

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding

Not Applicable

Conditions: Gastro Intestinal Bleeding

Interventions: Drug: Dextrose 40 % in Water
Drug: Adrenaline 1 Mg/mL Solution for Injection
Procedure: argon plasma coagulation
Procedure: Hemoclip

First Posted Date: 2021-07-28

Last Posted Date: 2021-07-28

Lead Sponsor: Dr Cipto Mangunkusumo General Hospital

Target Recruit Count: 66

Registration Number: NCT04979273

Locations: 🇮🇩
Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, Indonesia

Neonatal Pain Management and Pain Monitoring Using New Methods

Not Applicable

Recruiting

Conditions: Procedural Pain
Infant
Pain, Acute

Interventions: Drug: 30% oral glucose
Behavioral: Skin-to-skin contact
Behavioral: Mother's heartbeats as sound and vibration

First Posted Date: 2021-07-19

Last Posted Date: 2023-11-30

Lead Sponsor: University of Oulu

Target Recruit Count: 36

Registration Number: NCT04967118

Locations: 🇫🇮
Oulu University Hospita, Oulu, Finland

The Effect of Dextrose Prolotherapy on Isokinetic Power in the Treatment of Knee Osteoarthritis

Phase 4

Completed

Conditions: Physical Therapy
Dextrose Prolotherapy Injection
Knee Osteoarthritis

Interventions: Combination Product: conventional physical therapy
Drug: Dextrose prolotherapy injection

First Posted Date: 2021-07-12

Last Posted Date: 2021-07-12

Lead Sponsor: Mustafa Kemal University

Target Recruit Count: 60

Registration Number: NCT04958213

Locations: 🇹🇷
Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Turkey

Drug Development Updates

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