Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
A Study of Inhaled Fentanyl Aerosol in Chinese Patients With Malignant Tumors
- Conditions
- Cancer
- Interventions
- First Posted Date
- 2025-05-01
- Last Posted Date
- 2025-05-11
- Lead Sponsor
- Lee's Pharmaceutical Limited
- Target Recruit Count
- 100
- Registration Number
- NCT06953453
- Locations
- 🇨🇳
Shanghai Sixth People's Hospital, Shanghai, Shanghai, China
The Efficacy of Scalp Block in Craniotomy
- Conditions
- Post-operative PainNarcotics ConsumptionPain AssessmentIntraoperative Hemodynamic Instability
- Interventions
- Procedure: scalp block
- First Posted Date
- 2025-04-30
- Last Posted Date
- 2025-04-30
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 20
- Registration Number
- NCT06951230
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Dexmedetomidine Enhancing the Recovery After Cardiac Surgery
- Conditions
- Post-cardiac Surgery
- Interventions
- First Posted Date
- 2025-04-02
- Last Posted Date
- 2025-04-02
- Lead Sponsor
- Benha University
- Target Recruit Count
- 75
- Registration Number
- NCT06907277
- Locations
- 🇪🇬
Benha University, Banhā, El Qalyoubia, Egypt
Midazolam or Fentanyl as Adjuvants to Epidural Bupivacaine Plus Dexamethasone for Analgesia
- Conditions
- Lumbar Spine Fixation
- Interventions
- Drug: epidural midazolam
- First Posted Date
- 2025-03-27
- Last Posted Date
- 2025-03-27
- Lead Sponsor
- Zagazig University
- Target Recruit Count
- 102
- Registration Number
- NCT06898697
- Locations
- 🇪🇬
Faculty of Medicine,Zagazig University, Zagazig, Egypt
Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine
- Conditions
- Opioid Use Disorder
- Interventions
- First Posted Date
- 2025-03-25
- Last Posted Date
- 2025-03-25
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 46
- Registration Number
- NCT06784180
- Locations
- 🇺🇸
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Reducing Pain With Methadone and Ketamine in Liver Transplant
- Conditions
- Liver Transplantation
- Interventions
- First Posted Date
- 2025-03-11
- Last Posted Date
- 2025-05-09
- Lead Sponsor
- Lahey Clinic
- Target Recruit Count
- 50
- Registration Number
- NCT06868589
- Locations
- 🇺🇸
Lahey Hospital and Medical Center, Burlington, Massachusetts, United States
Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery
- Conditions
- AnesthesiaTooth Extraction
- Interventions
- First Posted Date
- 2025-03-10
- Last Posted Date
- 2025-03-10
- Lead Sponsor
- Albert Einstein College of Medicine
- Target Recruit Count
- 73
- Registration Number
- NCT06867068
- Locations
- 🇺🇸
NYCHHC - Jacobi Medical Center and North Central Bronx Hospital, Bronx, New York, United States
Dexmedetomidine and Fentanyl As Adjuvants to Hyperbaric Bupivacaine for the Prevention of Post-spinal Shivering in Hip Arthroplasty Surgeries
- Conditions
- Post Spinal Shivering
- Interventions
- First Posted Date
- 2025-02-19
- Last Posted Date
- 2025-02-19
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 100
- Registration Number
- NCT06834841
- Locations
- 🇪🇬
Ain Shams University, Cairo, Egypt
Opioid Free Anesthesia in Shoulder Arthroscope
- Conditions
- Measure Time to First Rescue Analgesia Following Extubation
- Interventions
- First Posted Date
- 2025-02-19
- Last Posted Date
- 2025-02-19
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT06834854
- Locations
- 🇪🇬
Ain shams university, Cairo, Egypt
Comparative Analysis of Analgesic Efficacy and Maternal Satisfaction: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
- Conditions
- Vaginal DeliveryNormal Labor
- Interventions
- First Posted Date
- 2025-02-12
- Last Posted Date
- 2025-03-07
- Lead Sponsor
- Jehan George Sadek
- Target Recruit Count
- 90
- Registration Number
- NCT06823349
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Drug Development Updates
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