Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Comparative Study Between Two Adjuvant Drugs to Bupivacaine for Post-operative Epidural Analgesia in Abdominal Surgeries
- Conditions
- Epidural Analgesia
- Interventions
- Drug: Control Analgesic regimen
- First Posted Date
- 2022-04-12
- Last Posted Date
- 2022-07-15
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 75
- Registration Number
- NCT05323214
- Locations
- 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt
Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia
- Conditions
- Cardiac OutputCesarean SectionAnesthesia, SpinalEchocardiography
- Interventions
- Radiation: Transthoracic EchocardiographyProcedure: Spinal AnesthesiaDrug: Crystalloid Coload 1000 mLProcedure: Cesarean Delivery
- First Posted Date
- 2022-03-08
- Last Posted Date
- 2022-11-29
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 60
- Registration Number
- NCT05269537
- Locations
- 🇪🇬
Department of Anesthesia and Surgical Critical Care, Mansoura University Hospitals, Mansoura, Dakahlia, Egypt
Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation
- Conditions
- Patient With Nasolacrimal Duct ObstructionExternal Dacryocystorhinostomy Operation
- Interventions
- Procedure: Mechanical ventilationOther: Head-up tilt
- First Posted Date
- 2022-02-15
- Last Posted Date
- 2022-02-15
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 64
- Registration Number
- NCT05241054
- Locations
- 🇪🇬
Mansoura University, Mansoura, DK, Egypt
An Observation Study to Assess the Efficacy and Safety of Proportional Doses of Painkyl® in Patients With Breakthrough Cancer Pain
- Conditions
- Cancer Pain
- First Posted Date
- 2022-01-27
- Last Posted Date
- 2022-08-23
- Lead Sponsor
- Mackay Memorial Hospital
- Target Recruit Count
- 37
- Registration Number
- NCT05209906
- Locations
- 🇨🇳
MacKay Memorial Hospital, New Taipei City, Taiwan
Efficacy and Safety of Butorphanol Tartrate Injection for the Patients With Mechanical Ventilation
- Conditions
- Hospital-acquired InfectionsAnalgesia
- Interventions
- First Posted Date
- 2022-01-21
- Last Posted Date
- 2022-01-21
- Lead Sponsor
- Shanghai Zhongshan Hospital
- Target Recruit Count
- 40
- Registration Number
- NCT05201560
Nebulized Fentanyl for Respiratory Symptoms in Patients With COVID-19
- First Posted Date
- 2021-12-21
- Last Posted Date
- 2022-01-13
- Lead Sponsor
- Hamad Medical Corporation
- Target Recruit Count
- 200
- Registration Number
- NCT05165992
Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
- Conditions
- Post Operative Pain, Acute
- Interventions
- First Posted Date
- 2021-12-09
- Last Posted Date
- 2025-01-29
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 80
- Registration Number
- NCT05150795
- Locations
- 🇪🇬
Ain-Shams University, Cairo, Egypt
Effect of Topically Administered Levobupivacaine- Fentanyl Versus Levobupivacaine- Dexamethasone Combination in the Control of Pain After Endoscopic Sinus Surgery
- Conditions
- Endoscopic Sinus SurgeryFentanyl
- Interventions
- First Posted Date
- 2021-12-06
- Last Posted Date
- 2021-12-06
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT05145543
- Locations
- 🇪🇬
Assiut governorate, Assiut, Egypt
A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine
- Conditions
- Acute PainAmbulances
- Interventions
- First Posted Date
- 2021-11-30
- Last Posted Date
- 2023-11-14
- Lead Sponsor
- Oslo University Hospital
- Target Recruit Count
- 338
- Registration Number
- NCT05137184
- Locations
- 🇳🇴
Sykehuset Innlandet, Gjøvik, Norway
Opioid-free Anesthesia in Laparoscopic Cholecystectomies
- Conditions
- Pain, PostoperativePain, AcuteLidocaineAnalgesiaAnalgesicsKetamineDexmedetomidinePain, ChronicCholecystectomyCentral Nervous System Depressants
- Interventions
- Drug: ketamine-lidocaine-dexmedetomidine
- First Posted Date
- 2021-10-22
- Last Posted Date
- 2023-02-24
- Lead Sponsor
- Aretaieion University Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT05089526
- Locations
- 🇬🇷
Evangelismos General Hospital, Athens, Greece
Drug Development Updates
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