Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

Clinical Effectiveness of Erector Spinae Plane Block in Peri-operative Analgesia for Nephrectomy/Nephron Sparing Surgery(NSS) Performed Via Lumbotomy

Not Applicable

Conditions: Erector Spinae Plane Block

Interventions: Drug: Morphine PCA pump
Procedure: ESP block
Drug: Fentanyl

First Posted Date: 2019-03-22

Last Posted Date: 2019-03-22

Lead Sponsor: Medical University of Warsaw

Target Recruit Count: 42

Registration Number: NCT03887260

Locations: 🇵🇱
Warsaw Clinical University Center, Warsaw, Poland

Open-Label CA-008 (Vocacapsaicin) in Bunionectomy

Phase 2

Completed

Conditions: Pain

Interventions: Drug: CA-008
Drug: Ketorolac
Drug: Acetaminophen IV
Drug: Fentanyl
Drug: Bupivacaine Hydrochloride
Drug: Lidocaine HCl
Drug: Exparel
Drug: Acetaminophen Oral
Drug: Celecoxib
Drug: Lidocaine Hydrochloride

First Posted Date: 2019-03-21

Last Posted Date: 2021-10-27

Lead Sponsor: Concentric Analgesics

Target Recruit Count: 36

Registration Number: NCT03885596

Locations: 🇺🇸
Lotus Clinical Research, LLC, Pasadena, California, United States

Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery

Phase 2

Completed

Conditions: Monitored Anesthesia Care

Interventions: Drug: Magnesium Sulphate
Drug: Fentanyl
Drug: Propofol

First Posted Date: 2019-02-26

Last Posted Date: 2021-04-13

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 32

Registration Number: NCT03854812

Locations: 🇪🇬
Kasr Alaini Hospital, Cairo, Egypt

Morphine or Fentanyl for Refractory Dyspnea in COPD

Phase 4

Active, not recruiting

Conditions: COPD

Interventions: Drug: Morphine Retard
Drug: Fentanyl
Drug: Placebo patch
Drug: Placebo oral capsule

First Posted Date: 2019-02-07

Last Posted Date: 2024-06-10

Lead Sponsor: Huib A.M. Kerstjens

Target Recruit Count: 59

Registration Number: NCT03834363

Locations: 🇳🇱
Medisch Spectrum Twente, Enschede, Overijssel, Netherlands
🇳🇱
Ommelander Ziekenhuis Groningen, Scheemda, Groningen, Netherlands
🇳🇱
Spaarne Gasthuis, Haarlem, Noord-Holland, Netherlands

and more 7 locations