Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)

Phase 2

Active, not recruiting

Conditions: Depression, Postpartum
Anesthesia, Obstetrical
Analgesia, Obstetrical

Interventions: Drug: Entonox
Device: Epidural delivery system
Drug: Fentanyl
Drug: Meperidine
Drug: Ropivacaine
Drug: Ultiva

First Posted Date: 2017-05-30

Last Posted Date: 2024-01-05

Lead Sponsor: KK Women's and Children's Hospital

Target Recruit Count: 881

Registration Number: NCT03167905

Locations: 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore

Comparison Between IV Propofol and Propofol/ Fentanyl Anesthesia on Patients Stress Response

Phase 2

Conditions: Stress

Interventions: Drug: Propofol
Drug: Fentanyl

First Posted Date: 2017-05-08

Last Posted Date: 2017-05-08

Lead Sponsor: Cairo University

Target Recruit Count: 40

Registration Number: NCT03143933

Locations: 🇪🇬
Kasr Al Aini, Cairo, Egypt

Analgesic Effects of Transversus Thoracic Plane (TTP) Block in Cardiac Surgery

Not Applicable

Conditions: Nerve Block
Postoperative Pain
Cardiac Surgery

Interventions: Procedure: Transthoracic Transversus Plane Block
Drug: Hydromorphone Hydrochloride
Drug: Aspirin
Drug: Acetaminophen
Drug: Fentanyl

First Posted Date: 2017-04-25

Last Posted Date: 2017-09-05

Lead Sponsor: Western University, Canada

Target Recruit Count: 100

Registration Number: NCT03128346

Locations: 🇨🇦
London Health Sciences Centre, London, Ontario, Canada

Comparison of Opioid Based and Opioid Free Anaesthesia in Transsphenoidal Surgery

Not Applicable

Completed

Conditions: Opioid Free Anaesthesia

Interventions: Drug: Fentanyl
Drug: Dexmedetomidine
Drug: Ketamine
Drug: Placebos

First Posted Date: 2017-04-19

Last Posted Date: 2019-07-08

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 60

Registration Number: NCT03120234

Locations: 🇮🇳
Post graduation institute of medical education and research, Chandigarh, India

Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia

Not Applicable

Conditions: Postoperative Delirium

Interventions: Drug: Dexmedetomidine
Drug: Propofol
Drug: Fentanyl

First Posted Date: 2017-04-19

Last Posted Date: 2021-09-21

Lead Sponsor: Mahidol University

Target Recruit Count: 600

Registration Number: NCT03120442

Locations: 🇹🇭
Siriraj Hospital, Bangkok noi, Bangkok, Thailand

Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery

Phase 4

Terminated

Conditions: Pain

Interventions: Drug: Hydromorphone
Drug: Bupivacaine
Drug: Fentanyl

First Posted Date: 2017-04-14

Last Posted Date: 2023-10-26

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 46

Registration Number: NCT03115151

Locations: 🇺🇸
University Of Texas Southwestern Medical Center, Zale University Hospital, Dallas, Texas, United States
🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States