Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Sedation Strategies for Diagnostic Bronchoscopy
- Conditions
- Interventions
- First Posted Date
- 2018-01-23
- Last Posted Date
- 2019-06-12
- Lead Sponsor
- Changhai Hospital
- Target Recruit Count
- 28
- Registration Number
- NCT03406533
- Locations
- 🇨🇳
Faculty of Anesthesiology, Changhai Hospital, Shanghai, Shanghai, China
The Effect of Opioids on P2Y12 Receptor Inhibition in Patients With ST-Elevation Myocardial Infarction Who Are Pre-treated With Crushed Ticagrelor
- Conditions
- Interventions
- First Posted Date
- 2018-01-17
- Last Posted Date
- 2020-02-12
- Lead Sponsor
- A.H. Tavenier
- Target Recruit Count
- 200
- Registration Number
- NCT03400267
- Locations
- 🇳🇱
Isala clinics, Zwolle, Netherlands
BIS of Sedation Depth During Flexible Bronchoscopy.
- Conditions
- Interventions
- First Posted Date
- 2018-01-10
- Last Posted Date
- 2018-01-10
- Target Recruit Count
- 500
- Registration Number
- NCT03395093
Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section
- Conditions
- Interventions
- First Posted Date
- 2017-12-26
- Last Posted Date
- 2020-01-13
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 26
- Registration Number
- NCT03383588
- Locations
- 🇺🇸
Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, New York, United States
Post-operative Pain Relief in Laparoscopic Cholecystectomy
- Conditions
- Interventions
- First Posted Date
- 2017-11-28
- Last Posted Date
- 2017-11-28
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 120
- Registration Number
- NCT03355716
Evaluation of DEX-IN During Outpatient Procedures
- First Posted Date
- 2017-11-20
- Last Posted Date
- 2023-05-25
- Lead Sponsor
- Baudax Bio
- Target Recruit Count
- 45
- Registration Number
- NCT03348423
- Locations
- 🇺🇸
Research Center, Pasadena, California, United States
Effect of Epidural Opioid Administered in the First A Period on the Progress of Labour
- First Posted Date
- 2017-11-17
- Last Posted Date
- 2018-12-06
- Lead Sponsor
- Medical University of Warsaw
- Target Recruit Count
- 300
- Registration Number
- NCT03344042
- Locations
- 🇵🇱
Uniwersyteckie Centrum Zdrowia Kobiety i Noworodka, WUM, Warszawa, Mazowieckie, Poland
Quadratus Lumborum Block vs Transversus Abdominis Plane Block for Post-cholecystectomy Analgesia
- First Posted Date
- 2017-10-27
- Last Posted Date
- 2018-05-01
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 159
- Registration Number
- NCT03323684
- Locations
- 🇪🇬
Mansoura University, Faculty of Medicine, Mansourah, DK, Egypt
🇪🇬Mansoura University, Mansourah, DK, Egypt
Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients
- First Posted Date
- 2017-10-27
- Last Posted Date
- 2019-07-23
- Lead Sponsor
- Nazmy Edward Seif
- Target Recruit Count
- 60
- Registration Number
- NCT03324490
- Locations
- 🇪🇬
Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt
Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery.
- First Posted Date
- 2017-10-11
- Last Posted Date
- 2020-05-12
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 120
- Registration Number
- NCT03307174
- Locations
- 🇺🇸
University of California San Francisco, San Francisco, California, United States
Drug Development Updates
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