Fentanyl
- Generic Name
- Fentanyl
- Brand Names
- Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent
- Drug Type
- Small Molecule
- Chemical Formula
- C22H28N2O
- CAS Number
- 437-38-7
- Unique Ingredient Identifier
- UF599785JZ
- Background
Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.
Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.
Fentanyl was FDA approved in 1968.
- Indication
Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.
Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.
- Associated Conditions
- Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain
- Associated Therapies
- Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy
Effect of Addition of Fentanyl or Dexamethasone or Both to Bupivacaine in Paravertebral Block for Patients Undergoing Major Breast Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-03-29
- Last Posted Date
- 2021-02-23
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 1
- Registration Number
- NCT03480308
- Locations
- 🇪🇬
Amonios Khalil gerges, Assiut, Egypt
Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention
- Conditions
- Interventions
- First Posted Date
- 2018-03-26
- Last Posted Date
- 2024-01-24
- Lead Sponsor
- The Guthrie Clinic
- Target Recruit Count
- 80
- Registration Number
- NCT03476369
- Locations
- 🇺🇸
The Guthrie Clinic, Sayre, Pennsylvania, United States
Evaluation of the Analgesic Effect of Dexmedetomidine Versus Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
- Conditions
- Interventions
- First Posted Date
- 2018-03-13
- Last Posted Date
- 2018-05-30
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT03463083
- Locations
- 🇪🇬
Ahmed Abdalla Mohamed, Cairo, Egypt
Ketamine for Endoscopic Sedation in Outpatient Adult Endoscopy.
- Conditions
- Interventions
- First Posted Date
- 2018-03-12
- Last Posted Date
- 2020-07-08
- Lead Sponsor
- Brooke Army Medical Center
- Target Recruit Count
- 66
- Registration Number
- NCT03461718
- Locations
- 🇺🇸
Brooke Army Medical Center, Fort Sam Houston, Texas, United States
Precision Medicine in Anesthesia: Genetic Component in Opioid-induced Respiratory Depression
- First Posted Date
- 2018-02-22
- Last Posted Date
- 2024-12-11
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 26
- Registration Number
- NCT03441282
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
Post Operative Pain Control After Pediatric Hip Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-02-19
- Last Posted Date
- 2021-11-02
- Lead Sponsor
- Seattle Children's Hospital
- Target Recruit Count
- 42
- Registration Number
- NCT03435692
Dexmedetomidine Versus Fentanyl Plus Bupivacaine for Epidural Analgesia With General Anesthesia for Lumbar Disc Operations
- Conditions
- Interventions
- First Posted Date
- 2018-02-19
- Last Posted Date
- 2018-09-27
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 80
- Registration Number
- NCT03438240
- Locations
- 🇪🇬
Ain Shams University hospitals, Cairo, Egypt
Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy
- Conditions
- Interventions
- First Posted Date
- 2018-02-15
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 83
- Registration Number
- NCT03435003
- Locations
- 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States
Effects of Low Dose Neuromuscular Blocker Usage on Laryngeal Mask Application
- Conditions
- Interventions
- First Posted Date
- 2018-02-07
- Last Posted Date
- 2018-06-13
- Lead Sponsor
- TC Erciyes University
- Target Recruit Count
- 96
- Registration Number
- NCT03424356
- Locations
- 🇹🇷
Erciyes University, Kayseri, Turkey
Sequential Intrathecal Injection of Fentanyl and Hyperbaric Bupivacaine
- Conditions
- Interventions
- First Posted Date
- 2018-01-30
- Last Posted Date
- 2018-01-30
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 56
- Registration Number
- NCT03415087
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