Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

Depodur vs Fentanyl Infusion for Post-C/S Analgesia

Not Applicable

Withdrawn

Conditions: Analgesia

Interventions: Drug: Fentanyl
Drug: Depodur

First Posted Date: 2008-09-30

Last Posted Date: 2022-03-29

Lead Sponsor: Goodman, Evan, M.D.

Registration Number: NCT00762554

Locations: 🇺🇸
University Hospitals Case Medical Center, Cleveland, Ohio, United States

Ultrasound-Guided Axillary or Infraclavicular Nerve Block for Upper Limb Surgery

Phase 4

Completed

Conditions: Upper Extremity
Orthopedic Surgery
Trauma
Forearm Injuries
Nerve Block

Interventions: Drug: Midazolam
Drug: Ropivacaine
Drug: Fentanyl
Procedure: General anesthesia
Procedure: Infraclavicular brachial plexus block
Procedure: Axillary brachial plexus nerve block

First Posted Date: 2008-07-29

Last Posted Date: 2009-07-15

Lead Sponsor: University of Parma

Target Recruit Count: 52

Registration Number: NCT00724035

Locations: 🇮🇹
University Hospital / Azienda Ospedaliero-Universitaria, Parma, PR, Italy

Tramadol Versus Fentanyl for Post-Operative Analgesia in Newborn Infants

Phase 3

Completed

Conditions: Pain
Neonatal Infections
Analgesia

Interventions: Drug: FentanyL
Drug: Tramadol

First Posted Date: 2008-07-11

Last Posted Date: 2008-07-11

Lead Sponsor: Federal University of São Paulo

Target Recruit Count: 160

Registration Number: NCT00713726

Locations: 🇧🇷
Albert Sabin Hospital, Fortaleza, Ceará, Brazil

Effect of Total Intravenous Anesthesia and Balanced Anesthesia on Postoperative Lung Function

Phase 4

Completed

Conditions: Lung Function

Interventions: Drug: propofol
Drug: remifentanil
Drug: fentanyl
Drug: Sevoflurane/Nitrous Oxide

First Posted Date: 2008-06-27

Last Posted Date: 2009-02-10

Lead Sponsor: Medical University Innsbruck

Target Recruit Count: 60

Registration Number: NCT00706277

Locations: 🇦🇹
TILAK Hospitals, Innsbruck, Austria

Ultrasound Guidance for Interscalene Brachial Plexus Block

Phase 4

Completed

Conditions: Shoulder
Orthopedic Surgery
Nerve Block

Interventions: Procedure: Ultrasound-guided continuous interscalene brachial plexus block
Procedure: Continuous interscalene brachial plexus block using electrical nerve stimulation
Drug: Ropivacaine
Drug: Paracetamol
Drug: Morphine
Drug: Fentanyl
Procedure: General anesthesia