Magnesium sulfate
- Generic Name
- Magnesium sulfate
- Brand Names
- Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
- Drug Type
- Small Molecule
- Chemical Formula
- MgO4S
- CAS Number
- 7487-88-9
- Unique Ingredient Identifier
- ML30MJ2U7I
- Background
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
- Indication
Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
- Associated Conditions
- Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
- Associated Therapies
- Bowel preparation therapy, Soaking aid for minor sprains and bruises
Bilateral Transversus Abdominis Plane Block With or Without Magnesium
- First Posted Date
- 2016-02-11
- Last Posted Date
- 2023-04-13
- Lead Sponsor
- Dr. Anthony Ho
- Target Recruit Count
- 86
- Registration Number
- NCT02680626
- Locations
- 🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada
Magnesium Sulfate Effects on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy
- Conditions
- Interventions
- First Posted Date
- 2016-02-01
- Last Posted Date
- 2016-02-01
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 75
- Registration Number
- NCT02669368
- Locations
- 🇪🇬
Assiut University Hospitals, Assiut, Egypt
Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study
- Conditions
- Interventions
- First Posted Date
- 2016-01-06
- Last Posted Date
- 2017-07-17
- Target Recruit Count
- 26
- Registration Number
- NCT02647268
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Magnesium Sulfate in Adductor Canal Blocks
- Conditions
- Interventions
- First Posted Date
- 2015-10-21
- Last Posted Date
- 2020-11-13
- Lead Sponsor
- Queen's University
- Target Recruit Count
- 130
- Registration Number
- NCT02581683
- Locations
- 🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada
🇨🇦Hotel Dieu Hospital, Kingston, Ontario, Canada
Efficacy and Safety of MgSO4 as Tocolytics Compared to Ritodrine in Preterm Labor
- First Posted Date
- 2015-09-02
- Last Posted Date
- 2019-04-25
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT02538718
- Locations
- 🇰🇷
Seoul Metropolitan Goverment Seoul National University Boramae Medical Center, Seoul, Korea, Republic of
🇰🇷Seoul National University Hospital, Seoul, Korea, Republic of
Magnesium Sulfate for TAP Analgesia During Laparoscopic Cholecystectomy
- Conditions
- Interventions
- First Posted Date
- 2015-08-26
- Last Posted Date
- 2015-08-26
- Lead Sponsor
- Mansoura University
- Target Recruit Count
- 90
- Registration Number
- NCT02533284
- Locations
- 🇪🇬
Mansoura university, Mansoura, Dkahleya, Egypt
Magnesium Sulfate and Bupivacaine for Rehabilitation After Distal Radius Fractures
- Conditions
- Interventions
- First Posted Date
- 2015-08-03
- Last Posted Date
- 2017-12-19
- Lead Sponsor
- Universidad Autonoma de Nuevo Leon
- Target Recruit Count
- 40
- Registration Number
- NCT02514343
- Locations
- 🇲🇽
Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico
Fetal Middle Cerebral Artery Doppler in Preterm Births Receiving Magnesium Sulfate for Neuroprotection
- Conditions
- Interventions
- First Posted Date
- 2015-07-23
- Last Posted Date
- 2016-02-01
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 60
- Registration Number
- NCT02506894
- Locations
- 🇪🇬
Cairo University, Cairo, Egypt
Hypothermia Enhanced by Magnesium Sulphate
- Conditions
- Interventions
- First Posted Date
- 2015-07-16
- Last Posted Date
- 2015-07-16
- Target Recruit Count
- 75
- Registration Number
- NCT02499393
- Locations
- 🇵🇱
Polish Mother Memorial Hospital - Research Instutiute, Lodz, Poland
Magnesium Sulfate to Prevent Hospitalisation of Acute Exacerbations of Chronic Obstructive Pulmonary Disease
- Conditions
- Interventions
- First Posted Date
- 2015-07-15
- Last Posted Date
- 2018-02-22
- Lead Sponsor
- Hôpital de Verdun
- Registration Number
- NCT02498496
Drug Development Updates
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