Magnesium sulfate

Generic Name
Magnesium sulfate
Brand Names
Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
Drug Type
Small Molecule
Chemical Formula
MgO4S
CAS Number
7487-88-9
Unique Ingredient Identifier
ML30MJ2U7I
Background

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Indication

Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.

Associated Conditions
Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
Associated Therapies
Bowel preparation therapy, Soaking aid for minor sprains and bruises
Clinical Trials
Related News

Shivering Prevention During Cesarean Section by Intrathecal Injection of Magnesium Sulfate

Phase 2
Completed
Conditions
Cesarean Section; Shivering
Interventions
Drug: Placebo
Drug: MgSo4
First Posted Date
2017-01-04
Last Posted Date
2017-01-05
Lead Sponsor
Assiut University
Target Recruit Count
84
Registration Number
NCT03008850
Locations
🇪🇬

Assiut university hospital, Assiut, Egypt

Magnesium Sulfate Effect Following the Reversal of Neuromuscular Blockade Induced by Rocuronium With Sugammadex

Phase 4
Completed
Conditions
Neuromuscular Blockade
Interventions
Drug: Saline
Drug: Magnesium Sulfate
First Posted Date
2016-10-13
Last Posted Date
2018-02-12
Lead Sponsor
Universidade Federal do Rio de Janeiro
Target Recruit Count
60
Registration Number
NCT02932254
Locations
🇧🇷

Hospital Federal de Bonsucesso, Rio de Janeiro, RJ, Brazil

TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy

First Posted Date
2016-10-12
Last Posted Date
2016-10-12
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT02930707

The Effect of Magnesium Therapy to Prevent Post-operative Atrial Fibrillation After Cardiac Surgery in Adults

Not Applicable
Completed
Conditions
Atrial Fibrillation
Interventions
Drug: Magnesium Sulfate
Other: control
First Posted Date
2016-10-10
Last Posted Date
2016-10-10
Lead Sponsor
Assiut University
Target Recruit Count
40
Registration Number
NCT02928315
Locations
🇪🇬

Emad Zarief Kamel Said, Assiut, Egypt

Effect of Intravenous Magnesium During Robot Assisted Prostatectomy

Not Applicable
Completed
Conditions
Prostatic Neoplasms
Interventions
Drug: Magnesium Sulfate
Drug: Normal saline
First Posted Date
2016-07-14
Last Posted Date
2019-04-05
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
60
Registration Number
NCT02833038
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Seoum, Korea, Republic of

Effect of Intravenous Magnesium on Postoperative Sore Throat After Thyroidectomy

Not Applicable
Completed
Conditions
Thyroid Neoplasms
Interventions
Drug: Normal saline
Drug: Magnesium Sulfate
First Posted Date
2016-07-11
Last Posted Date
2019-04-05
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
20
Registration Number
NCT02826746
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, Seoum, Korea, Republic of

Intraperitoneal Analgesia in Pediatric Laparoscopy

First Posted Date
2016-07-01
Last Posted Date
2020-01-03
Lead Sponsor
Assiut University
Target Recruit Count
97
Registration Number
NCT02820610
Locations
🇪🇬

Faculty of Medicine Assuit University, Asyut, Assuit, Egypt

Magnesium Sulphate in the Ultrasound-guided Supraclavicular Brachial Plexus Block

Phase 2
Completed
Conditions
Pain
Interventions
Drug: Magnesium Sulphate
First Posted Date
2016-04-26
Last Posted Date
2019-03-08
Lead Sponsor
Magrabi Eye & Ear Hospital
Target Recruit Count
60
Registration Number
NCT02752334
Locations
🇪🇬

Tanta University Hospitals, Tanta, Egypt

Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia

First Posted Date
2016-03-04
Last Posted Date
2017-06-06
Lead Sponsor
Mohamed Sayed Abdelhafez
Target Recruit Count
60
Registration Number
NCT02699827
Locations
🇪🇬

Mansoura University Hospital, Mansoura, Dakahlia, Egypt

Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure

First Posted Date
2016-02-17
Last Posted Date
2020-10-19
Lead Sponsor
Theodor Bilharz Research Institute
Target Recruit Count
60
Registration Number
NCT02684019
Locations
🇪🇬

Theodor Bilharz Research Institute, Giza, Egypt

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