Magnesium sulfate
- Generic Name
- Magnesium sulfate
- Brand Names
- Concept Ob, Suflave, Suprep Bowel Prep Kit, Tis-U-sol
- Drug Type
- Small Molecule
- Chemical Formula
- MgO4S
- CAS Number
- 7487-88-9
- Unique Ingredient Identifier
- ML30MJ2U7I
- Background
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
- Indication
Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
- Associated Conditions
- Constipation, Convulsions, Hypomagnesemia, Torsades de Pointes, Barium poisoning, Severe Exacerbation of asthma
- Associated Therapies
- Bowel preparation therapy, Soaking aid for minor sprains and bruises
Pediatric Caudal Dexmedetomidine Enhances Postoperative Analgesia of Magnesium Sulphate in Lower Abdominal Surgeries
- First Posted Date
- 2015-07-01
- Last Posted Date
- 2017-09-26
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 120
- Registration Number
- NCT02487355
- Locations
- 🇪🇬
Assiut Univeristy Hospital, Assiut, Egypt
Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
- Conditions
- Interventions
- First Posted Date
- 2015-06-29
- Last Posted Date
- 2016-01-15
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 48
- Registration Number
- NCT02483611
Ketamine and Neuropathic Pain
- First Posted Date
- 2015-06-10
- Last Posted Date
- 2016-07-29
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Target Recruit Count
- 22
- Registration Number
- NCT02467517
- Locations
- 🇫🇷
CHU de Clermont-Ferrand, Clermont-Ferrand, France
The Effect of Magnesium on Maternal Mood, Cognitive Function, and Birth Experience
- First Posted Date
- 2015-05-27
- Last Posted Date
- 2022-05-05
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 300
- Registration Number
- NCT02454322
- Locations
- 🇺🇸
Northwestern Memorial Hospital, Chicago, Illinois, United States
Helping Stroke Patients With ThermoSuit Cooling
- Conditions
- Interventions
- First Posted Date
- 2015-05-25
- Last Posted Date
- 2023-06-06
- Lead Sponsor
- Life Recovery Systems
- Target Recruit Count
- 14
- Registration Number
- NCT02453373
- Locations
- 🇺🇸
Geisinger Medical Center, Danville, Pennsylvania, United States
🇺🇸U of SC School of Medicine, Columbia, South Carolina, United States
🇺🇸Tulane University, New Orleans, Louisiana, United States
The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation
- Conditions
- Interventions
- First Posted Date
- 2015-02-10
- Last Posted Date
- 2015-02-10
- Lead Sponsor
- Hospital de Base
- Target Recruit Count
- 49
- Registration Number
- NCT02359370
Magnesium Sulfate in Pregnancy and Postpartum
- Conditions
- Interventions
- First Posted Date
- 2014-12-15
- Last Posted Date
- 2017-02-01
- Lead Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
- Target Recruit Count
- 280
- Registration Number
- NCT02317146
- Locations
- 🇵🇦
Hospital Jose Domingo de Obaldia, Chiriqui, Panama
🇵🇦Hospital Manuel Amador Guerrero, Colon, Panama
🇵🇦Complejo Hospitalario Caja de Seguro Social, Panamá, Panama
Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia
- First Posted Date
- 2014-12-04
- Last Posted Date
- 2017-02-01
- Lead Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
- Target Recruit Count
- 1114
- Registration Number
- NCT02307201
- Locations
- 🇵🇦
Hospital Santo Tomás, Panamá, Panama
🇩🇴Hospital Materno Infantil san Lorezo de las Minas, Santo Domingo, Dominican Republic
🇩🇴Hospital Universitario Maternidad Nuestra señoa de Alta Gracia, Santo Domingo, Dominican Republic
Assessment of a Syringe Pump to Pre-eclamptic Women in a Low-resource Hospital
- First Posted Date
- 2014-11-21
- Last Posted Date
- 2017-11-06
- Lead Sponsor
- William Marsh Rice University
- Target Recruit Count
- 34
- Registration Number
- NCT02296931
- Locations
- 🇲🇼
Queen Elizabeth Central Hospital, Blantyre, Malawi
The Effect of Perioperative Intravenous Magnesium on Pain After Endoscopic Submucosal Dissection for Gastric Neoplasm: Prospective Randomized Double-blind Placebo Controlled Study
- First Posted Date
- 2014-09-09
- Last Posted Date
- 2015-05-12
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 60
- Registration Number
- NCT02235246
- Locations
- 🇰🇷
Sevrance hospital, Seoul, Korea, Republic of
Drug Development Updates
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