Remimazolam
- Generic Name
- Remimazolam
- Brand Names
- Byfavo
- Drug Type
- Small Molecule
- Chemical Formula
- C21H19BrN4O2
- CAS Number
- 308242-62-8
- Unique Ingredient Identifier
- 7V4A8U16MB
- Background
Remimazolam is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as remifentanil, are designed to be metabolically fragile and thus susceptible to rapid biotransformation and elimination as inactive metabolites. These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed. Remimazolam was the first "soft" benzodiazepine analog to be developed and was approved for use by the FDA in July 2020 under the brand name Byfavo.
- Indication
Remimazolam is indicated for the induction and maintenance of procedural sedation in adults undergoing procedures lasting 30 minutes or less.
- Associated Conditions
- Procedural Sedation
Comparison of Quality of Recovery Between Remimazolam and Propofol Anesthesia in Patients Undergoing Arthroscopic Meniscectomy
- Conditions
- Adult Patients 19 or Older Scheduled for Elective Arthroscopic Meniscectomy
- Interventions
- First Posted Date
- 2022-03-15
- Last Posted Date
- 2024-07-08
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 80
- Registration Number
- NCT05280236
- Locations
- 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of
A Non-interventional Study of Remazolam Methyl Benzene Sulfonic Acid for Injection in Real-world Clinical Practice
- Conditions
- Gastroscopic and Colonoscopic Sedation
- Interventions
- First Posted Date
- 2022-02-24
- Last Posted Date
- 2022-02-24
- Lead Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
- Target Recruit Count
- 2000
- Registration Number
- NCT05254366
Effect on Early Cognition Under Sedation by Rimazole Toluenesulfonate in Old Patient Undergoing Colonoscopy
- Conditions
- Cognition
- Interventions
- First Posted Date
- 2022-02-24
- Last Posted Date
- 2024-03-18
- Lead Sponsor
- RenJi Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT05255211
- Locations
- 🇨🇳
Yongming Chen, Shanghai, Shanghai, China
Remimazolam vs Midazolam Cognitive and Motor Recovery After Intravenous Conscious Sedation for Dental Extractions.
- First Posted Date
- 2022-02-02
- Last Posted Date
- 2023-12-05
- Lead Sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Target Recruit Count
- 128
- Registration Number
- NCT05220462
- Locations
- 🇬🇧
Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Remimazolam and Propofol Anesthesia in Elderly Patients
- Conditions
- Hemodynamics
- Interventions
- First Posted Date
- 2022-01-21
- Last Posted Date
- 2023-07-25
- Lead Sponsor
- Ajou University School of Medicine
- Target Recruit Count
- 69
- Registration Number
- NCT05201300
- Locations
- 🇰🇷
Ajou University Hospital, Suwon, Gyeonggi-do, Korea, Republic of
The Comparison of Hemodynamic Effects Between Remimazolam-remifentanil and Propofol-remifentanil in Patients Undergoing Laparoscopic Cholecystectomy
- Conditions
- Acute Cholecystitis
- Interventions
- First Posted Date
- 2021-12-20
- Last Posted Date
- 2022-11-07
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 274
- Registration Number
- NCT05164159
- Locations
- 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of
The Comparison of Hypotension Incidence Between Remimazolam and Propofol in Hypertensive Patients Undergoing Neurosurgery
- Conditions
- Patients Undergoing Neurosurgery
- Interventions
- First Posted Date
- 2021-12-20
- Last Posted Date
- 2022-11-07
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 100
- Registration Number
- NCT05164146
- Locations
- 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of
Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam
- Conditions
- Sedation and Analgesia
- Interventions
- First Posted Date
- 2021-12-16
- Last Posted Date
- 2023-07-14
- Lead Sponsor
- Zhujiang Hospital
- Target Recruit Count
- 440
- Registration Number
- NCT05160987
- Locations
- 🇨🇳
Department of Critical Care Medicine of Zhujiang Hospital,Southern Medical University, Guangzhou, Guangdong, China
A Study of Remimazolam Tosilate for Sedation in the ICU
- First Posted Date
- 2021-12-09
- Last Posted Date
- 2023-05-23
- Lead Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
- Target Recruit Count
- 60
- Registration Number
- NCT05152303
- Locations
- 🇨🇳
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients
- Conditions
- Remimazolam BesylateEtomidate Combined With PropofolElderly PatientsGastrointestinal Endoscopy
- Interventions
- First Posted Date
- 2021-11-02
- Last Posted Date
- 2023-07-14
- Lead Sponsor
- Peking University People's Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT05103696
- Locations
- 🇨🇳
Peking University People's Hospital, Beijing, Beijing, China
Drug Development Updates
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