Epinephrine

Generic Name: Epinephrine

Brand Names: Adrenalin, Allerject, Anapen, Articadent, Astracaine, Auvi-Q, Citanest, Citanest Forte, Emerade, Epipen, Lignospan, Marcaine, Marcaine With Epinephrine, Octocaine, Octocaine With Epinephrine, Orabloc, Scandonest, Sensorcaine, Sensorcaine With Epinephrine, Septanest, Septocaine, Symjepi, Ultacan, Ultracaine, Vivacaine, Xylocaine, Xylocaine With Epinephrine, Zorcaine, Eurneffy

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₃

CAS Number: 51-43-4

Unique Ingredient Identifier: YKH834O4BH

Background: Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new produ...

Indication: Epinephrine injection is indicated in the emergency treatment of type I allergic reactions, including anaphylaxis. It is also used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
...

Associated Conditions: Anaphylaxis, Angioneurotic Edema, Bleeding, Bronchospasm, Complete Heart Block, Hypotension, Idiopathic Anaphylaxis, Laryngotracheobronchitis, Mild Intermittent Asthma, Nasal Congestion, Open Angle Glaucoma (OAG), Respiratory Distress, Severe Asthma, Syncope, Type I Hypersensitivity, Urticaria, Uterine Contractions, Ventricular Fibrillation, Resuscitation in cardiac arrest following anesthetic accidents, Severe hypersensitivity reactions, Unresponsive Asystole, Unresponsive Bradycardia

Associated Therapies: -

Clinical Trials

Ophthalmic Artery Resistance Index After Peribulbar Block in the Presence of Epinephrine

Not Applicable

Completed

Conditions: Peribulbar Block
Ophthalmic Artery

Interventions: Drug: Epinephrine

First Posted Date: 2019-11-06

Last Posted Date: 2019-11-06

Lead Sponsor: Federal University of Minas Gerais

Target Recruit Count: 26

Registration Number: NCT04153123

Locations: 🇧🇷
Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Cirurgia., Belo Horizonte, Minas Gerais, Brazil

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Phase 4

Conditions: Pain
Supratentorial Brain Tumor

Interventions: Drug: Ketorolac
Drug: Ropivacaine
Drug: Epinephrine

First Posted Date: 2019-10-28

Last Posted Date: 2020-01-22

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 100

Registration Number: NCT04141319

Evidence of Spreading Vasoconstriction in Human Gingiva

Not Applicable

Completed

Conditions: Dental and Gingival Conditions
Oral Soft Tissue Conditions
Vasoconstriction

Interventions: Drug: Epinephrine

First Posted Date: 2019-10-18

Last Posted Date: 2020-07-02

Lead Sponsor: Semmelweis University

Target Recruit Count: 29

Registration Number: NCT04131283

Locations: 🇭🇺
Janos Vag, Budapest, Hungary

Effect of Epinephrine on Post-polypectomy Pain

Phase 4

Completed

Conditions: Colonic Polyp

Interventions: Drug: Epinephrine

First Posted Date: 2019-08-22

Last Posted Date: 2022-09-30

Lead Sponsor: Indiana University

Target Recruit Count: 22

Registration Number: NCT04065451

Locations: 🇺🇸
Indiana University Hospital, Indianapolis, Indiana, United States

RCT of Gastric ESD With or Without Epineprhine Added Solution

Phase 3

Completed

Conditions: Gastric Neoplasm
Early Gastric Cancer

Interventions: Procedure: Endoscopic submucosal dissection
Drug: Epinephrine

First Posted Date: 2019-07-25

Last Posted Date: 2023-02-08

Lead Sponsor: Chinese University of Hong Kong

Target Recruit Count: 800

Registration Number: NCT04032119

Locations: 🇯🇵
Shizuoka Cancer Center, Shizuoka, Japan
🇯🇵
Kyoto 2nd Red Cross Hospital, Kyoto, Japan
🇸🇬
Changi General Hospital, Singapore, Singapore

and more 4 locations

Epinephrine Dose: Optimal Versus Standard Evaluation Trial

Phase 4

Recruiting

Conditions: Sudden Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital
Ventricular Fibrillation
Ventricular Tachycardia-Pulseless

Interventions: Drug: Epinephrine

First Posted Date: 2019-02-01

Last Posted Date: 2024-07-12

Lead Sponsor: Unity Health Toronto

Target Recruit Count: 3790

Registration Number: NCT03826524

Locations: 🇨🇦
British Columbia Emergency Health Services (BCEHS), Victoria, British Columbia, Canada
🇨🇦
Ottawa Paramedic Services, Ottawa, Ontario, Canada
🇨🇦
Halton Region Paramedic Services, Halton, Ontario, Canada