Epinephrine

Generic Name: Epinephrine

Brand Names: Adrenalin, Allerject, Anapen, Articadent, Astracaine, Auvi-Q, Citanest, Citanest Forte, Emerade, Epipen, Lignospan, Marcaine, Marcaine With Epinephrine, Octocaine, Octocaine With Epinephrine, Orabloc, Scandonest, Sensorcaine, Sensorcaine With Epinephrine, Septanest, Septocaine, Symjepi, Ultacan, Ultracaine, Vivacaine, Xylocaine, Xylocaine With Epinephrine, Zorcaine, Eurneffy

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₃

CAS Number: 51-43-4

Unique Ingredient Identifier: YKH834O4BH

Background: Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new produ...

Indication: Epinephrine injection is indicated in the emergency treatment of type I allergic reactions, including anaphylaxis. It is also used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock.
...

Associated Conditions: Anaphylaxis, Angioneurotic Edema, Bleeding, Bronchospasm, Complete Heart Block, Hypotension, Idiopathic Anaphylaxis, Laryngotracheobronchitis, Mild Intermittent Asthma, Nasal Congestion, Open Angle Glaucoma (OAG), Respiratory Distress, Severe Asthma, Syncope, Type I Hypersensitivity, Urticaria, Uterine Contractions, Ventricular Fibrillation, Resuscitation in cardiac arrest following anesthetic accidents, Severe hypersensitivity reactions, Unresponsive Asystole, Unresponsive Bradycardia

Associated Therapies: -

Clinical Trials

Peri-Incisional Drug Injection in Lumbar Spine Surgery

Phase 3

Withdrawn

Conditions: Degenerative Disc Disease
Lumbar Disc Herniation
Spondylolisthesis

Interventions: Drug: Morphine
Drug: Epinephrine
Drug: naropin

First Posted Date: 2018-05-01

Last Posted Date: 2022-08-19

Lead Sponsor: University of Minnesota

Registration Number: NCT03513445

Locations: 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States

Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks

Phase 4

Completed

Conditions: Distribution of Ropivacaine in Erector Spinae Plane Block

Interventions: Drug: Ropivacaine
Drug: Epinephrine

First Posted Date: 2018-03-26

Last Posted Date: 2024-04-16

Lead Sponsor: Milton S. Hershey Medical Center

Target Recruit Count: 12

Registration Number: NCT03476642

Locations: 🇺🇸
Milton S.Hershey Medical center, Hershey, Pennsylvania, United States

A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor

Phase 1

Completed

Conditions: Healthy Volunteers

Interventions: Drug: Ticagrelor 90mg
Drug: Epinephrine
Drug: Metoprolol

First Posted Date: 2018-02-22

Last Posted Date: 2018-05-11

Lead Sponsor: Vastra Gotaland Region

Target Recruit Count: 10

Registration Number: NCT03441412

Locations: 🇸🇪
gothia Forum CTC, Gothenburg, Sweden

Ultrasound-Guided Versus Conventional Method for Caudal Block

Not Applicable

Completed

Conditions: Ultrasound Therapy; Complications

Interventions: Drug: Bupivacaine
Drug: Adrenalin
Device: Ultrasound

First Posted Date: 2018-02-09

Last Posted Date: 2018-02-09

Lead Sponsor: Omer Karaca

Target Recruit Count: 275

Registration Number: NCT03427437

Locations: 🇹🇷
Baskent University, Konya, Turkey

Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section

Phase 2

Terminated

Conditions: Pain, Referred

Interventions: Drug: Bupivacaine
Drug: Morphine
Drug: Fentanyl
Drug: Epinephrine
Other: Saline solution

First Posted Date: 2017-12-26

Last Posted Date: 2020-01-13

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 26

Registration Number: NCT03383588

Locations: 🇺🇸
Albert Einstein College of Medicine/ Montefiore Medical Center, Bronx, New York, United States

Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery

Phase 4

Completed

Conditions: Endoscopic Sinus Surgery
Nasal Polyps

Interventions: Drug: Epinephrine
Drug: Oxymetazoline

First Posted Date: 2017-07-25

Last Posted Date: 2021-01-13

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 20

Registration Number: NCT03228914

Locations: 🇺🇸
The University of Texas Health Science Center at Houston, Houston, Texas, United States

Over-the-scope Clips and Standard Treatments in Endoscopic Control of Acute Bleeding From Non-variceal Upper GI Causes

Not Applicable

Completed

Conditions: Acute Upper Gastrointestinal Bleeding
Tumor Bleeding

Interventions: Device: Over-the-scope Clips
Device: Hemo-clipping
Device: thermo-coagulation
Drug: Epinephrine

First Posted Date: 2017-07-13

Last Posted Date: 2021-07-27

Lead Sponsor: Chinese University of Hong Kong

Target Recruit Count: 191

Registration Number: NCT03216395

Locations: 🇨🇳
The First Affliated Hospital of SooChow University, Suzhou, Jiangsu, China
🇨🇳
Beijing Friendship Hospital, Beijing, Beijing, China
🇨🇳
The First Affliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China

and more 5 locations