Clonidine

Generic Name
Clonidine
Brand Names
Catapres, Catapres-TTS, Catapres-tts-1, Duraclon, Kapvay, Nexiclon XR
Drug Type
Small Molecule
Chemical Formula
C9H9Cl2N3
CAS Number
4205-90-7
Unique Ingredient Identifier
MN3L5RMN02
Background

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.

Clonidine was granted FDA approval on 3 September 1974.

Indication

Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications. A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient. An extended release tablet of clonidine is indicated for the treatment of ADHD either alo...

Associated Conditions
Attention Deficit Hyperactivity Disorder (ADHD), Defiant Disorder, Oppositional, Gilles de la Tourette's Syndrome, Hot Flashes, Human Growth Hormone Deficiency, Hypertension, Opioid Withdrawal (Disorder), Pheochromocytoma, Postherpetic Neuralgia, Sialorrhea caused by clozapine, Diabetic diarrhea, Methadone withdrawal, Severe Cancer pain
Associated Therapies
Smoking, Cessation
Clinical Trials
Related News

The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients

Phase 3
Not yet recruiting
Conditions
Delirium
Interventions
Drug: SodiumChloride
Drug: Clonidine
First Posted Date
2013-06-12
Last Posted Date
2023-02-15
Lead Sponsor
Deventer Ziekenhuis
Target Recruit Count
115
Registration Number
NCT01876355
Locations
🇳🇱

Deventer Hospital, Deventer, Overijssel, Netherlands

Upregulation of Alpha-1 Receptors Upon Septic Shock?

Phase 2
Terminated
Conditions
Septic Shock
Interventions
Drug: Placebo
Drug: Clonidine
First Posted Date
2013-05-17
Last Posted Date
2017-07-28
Lead Sponsor
Direction Centrale du Service de Santé des Armées
Target Recruit Count
40
Registration Number
NCT01856517
Locations
🇫🇷

Critical Care Unit, Hopital Desgenettes, Lyon, France

The Relationships Between the Noradrenergic, Opioid and Pain System

First Posted Date
2013-05-10
Last Posted Date
2017-10-04
Lead Sponsor
Rambam Health Care Campus
Registration Number
NCT01851486
Locations
🇮🇱

Rambam Health Care Campus, Haifa, Israel

Comparison of Epidural Fentanyl and Clonidine for Breakthrough Pain

Phase 4
Completed
Conditions
Labor Pain
Interventions
Drug: Clonidine
Drug: Fentanyl
First Posted Date
2013-05-03
Last Posted Date
2018-05-03
Lead Sponsor
Columbia University
Target Recruit Count
101
Registration Number
NCT01846221
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Efficacy of Clonidine and Propranolol in Dentistry (AAA)

First Posted Date
2013-02-05
Last Posted Date
2013-02-05
Lead Sponsor
CES University
Target Recruit Count
60
Registration Number
NCT01784250
Locations
🇨🇴

Cooperative University, Envigado, Antioquia, Colombia

Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure

Phase 4
Completed
Conditions
Preeclampsia
Interventions
Drug: CLONIDINE
Drug: CAPTOPRIL
First Posted Date
2013-01-07
Last Posted Date
2013-07-29
Lead Sponsor
Instituto Materno Infantil Prof. Fernando Figueira
Target Recruit Count
90
Registration Number
NCT01761916
Locations
🇧🇷

IMIP, Recife, Pernambuco, Brazil

NAS Treatment - Opiate Versus Non-Opiate

Phase 4
Completed
Conditions
Neonatal Abstinence Syndrome
Interventions
Drug: Morphine
Drug: Clonidine
First Posted Date
2012-11-27
Last Posted Date
2017-09-12
Lead Sponsor
Henrietta Bada
Target Recruit Count
31
Registration Number
NCT01734551
Locations
🇺🇸

University of Kentucky Medical Center, Lexington, Kentucky, United States

Assessment of the Effect of Clonidine for Cataract Surgery

Phase 2
Conditions
Pain
Arrythmia
Interventions
Drug: Clonidine
Drug: placebo
First Posted Date
2012-09-03
Last Posted Date
2012-09-03
Lead Sponsor
Federal University of São Paulo
Target Recruit Count
40
Registration Number
NCT01677351
Locations
🇧🇷

Federal University of Sao Paulo, Sao Paulo, Brazil

Resistant Hypertension Optimal Treatment

First Posted Date
2012-07-18
Last Posted Date
2013-06-07
Lead Sponsor
Instituto do Coracao
Target Recruit Count
2000
Registration Number
NCT01643434
Locations
🇧🇷

University of São Paulo General Hospital, São Paulo, Brazil

The Effect of Clonidine in Glycemia During Coronary Artery Bypass Graft With Cardiopulmonary By-pass

First Posted Date
2012-06-14
Last Posted Date
2012-06-14
Lead Sponsor
Federal University of Juiz de Fora
Target Recruit Count
46
Registration Number
NCT01619436
Locations
🇧🇷

National institut of Cardiology, Rio de Janeiro, RJ, Brazil

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