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Clonidine

Generic Name
Clonidine
Brand Names
Catapres, Catapres-TTS, Catapres-tts-1, Duraclon, Kapvay, Nexiclon XR
Drug Type
Small Molecule
Chemical Formula
C9H9Cl2N3
CAS Number
4205-90-7
Unique Ingredient Identifier
MN3L5RMN02
Background

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.

Clonidine was granted FDA approval on 3 September 1974.

Indication

Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications. A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient. An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.

Clonidine is also used for the diagnosis of pheochromocytoma, treatment of nicotine dependance, and opiate withdrawal.

Associated Conditions
Attention Deficit Hyperactivity Disorder (ADHD), Defiant Disorder, Oppositional, Gilles de la Tourette's Syndrome, Hot Flashes, Human Growth Hormone Deficiency, Hypertension, Opioid Withdrawal (Disorder), Pheochromocytoma, Postherpetic Neuralgia, Sialorrhea caused by clozapine, Diabetic diarrhea, Methadone withdrawal, Severe Cancer pain
Associated Therapies
Smoking, Cessation
Clinical Trials
Related News

Medications Development for Drug Abuse Disorders

Phase 1
Completed
Conditions
Opioid Related Disorders
Opioid Dependence
Opioid Addiction
Interventions
Drug: Buprenorphine/naloxone
Drug: Tramadol ER
Drug: Clonidine
First Posted Date
2010-08-25
Last Posted Date
2017-07-06
Lead Sponsor
Johns Hopkins University
Target Recruit Count
106
Registration Number
NCT01188421
Locations
🇺🇸

Johns Hopkins University (BPRU) Bayview Campus, Baltimore, Maryland, United States

Treatment Resistant Depression (Pilot)

Not Applicable
Completed
Conditions
Depressive Disorder, Treatment-Resistant
Interventions
Drug: Ketamine
Drug: Clonidine
Drug: placebo
First Posted Date
2010-08-10
Last Posted Date
2023-09-15
Lead Sponsor
Washington University School of Medicine
Target Recruit Count
20
Registration Number
NCT01179009
Locations
🇺🇸

Washington University School of Medicine, Saint Louis, Missouri, United States

Clonidine for Neonatal Abstinence Syndrome Study

Not Applicable
Terminated
Conditions
Neonatal Abstinence Syndrome
Interventions
Drug: Clonidine
Drug: Phenobarbital
First Posted Date
2010-08-05
Last Posted Date
2014-01-06
Lead Sponsor
Baystate Medical Center
Target Recruit Count
68
Registration Number
NCT01175668
Locations
🇺🇸

NICU @ Baystate Children's Hospital, Springfield, Massachusetts, United States

Use of Transdermal Clonidine in Trauma Patients

Phase 4
Terminated
Conditions
Delirium
Interventions
Drug: Placebo
Drug: Clonidine
First Posted Date
2010-06-09
Last Posted Date
2017-06-14
Lead Sponsor
Memorial Health University Medical Center
Target Recruit Count
22
Registration Number
NCT01139996
Locations
🇺🇸

Memorial Health University Medical Center, Savannah, Georgia, United States

Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA)

Phase 1
Completed
Conditions
Mood Disorder
Substance-Related Disorders
Amphetamine-Related Disorders
Interventions
Drug: 3,4-Methylenedioxymethamphetamine
Drug: Clonidine
Drug: placebo
First Posted Date
2010-06-03
Last Posted Date
2013-01-25
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
16
Registration Number
NCT01136278
Locations
🇨🇭

Clinical Pharmacology & Toxicology, University Hospital Basel, Basel, Switzerland

Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery

Phase 4
Withdrawn
Conditions
Shoulder Arthroscopy
Knee Arthroscopy
Interventions
Drug: Gabapentin
Drug: Sugar pill
Drug: Clonidine
First Posted Date
2010-04-29
Last Posted Date
2015-09-14
Lead Sponsor
Cedars-Sinai Medical Center
Registration Number
NCT01112878
Locations
🇺🇸

Cedars Sinai Medical Center, Los Angeles, California, United States

Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine

Phase 4
Conditions
Spinal Anesthesia
Neonates
Interventions
Drug: clonidine
First Posted Date
2010-02-25
Last Posted Date
2010-02-25
Lead Sponsor
University Hospital, Montpellier
Target Recruit Count
120
Registration Number
NCT01075490
Locations
🇫🇷

CHU de Montpellier, Montpellier, France

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Not Applicable
Completed
Conditions
Osteoarthritis,Knee
Interventions
Drug: Ropivacaine
Drug: Toradol
Drug: Clonidine
Drug: Epinephrine
First Posted Date
2010-01-05
Last Posted Date
2013-11-08
Lead Sponsor
Towson Orthopaedic Associates
Target Recruit Count
160
Registration Number
NCT01042093

The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial

Phase 2
Completed
Conditions
Chronic Fatigue Syndrome
Myalgic Encephalomyelitis
Interventions
Drug: Lactose capsula
Drug: Clonidine
First Posted Date
2009-12-29
Last Posted Date
2012-11-20
Lead Sponsor
Oslo University Hospital
Target Recruit Count
120
Registration Number
NCT01040429
Locations
🇳🇴

Dept. of Pediatrics, Oslo University Hospital Rikshospitalet, Oslo, Norway

Transversus Abdominis Plane (TAP) Block for Cesarean Section

Not Applicable
Completed
Conditions
Hyperalgesia, Secondary
Interventions
Drug: Clonidine Placebo
Drug: Bupivacaine Placebo
Drug: Bupivacaine
Drug: Clonidine
First Posted Date
2009-11-18
Last Posted Date
2017-10-23
Lead Sponsor
University of Washington
Target Recruit Count
90
Registration Number
NCT01015807
Locations
🇺🇸

University of Washington, Seattle, Washington, United States

🇧🇷

Hospital e Maternidade Santa Joana, São Paulo, Brazil

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