Amitriptyline

Generic Name: Amitriptyline

Brand Names: Elavil

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₃N

CAS Number: 50-48-6

Unique Ingredient Identifier: 1806D8D52K

Background: Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.

Indication: This drug in indicated for the following conditions :

Major depressive disorder in adults

Management of neuropathic pain in adults

Prophylactic treatment of chronic tension-type headache (CTTH) in adults

Prophylactic treatment of migraine in adults
...

Associated Conditions: Anorexia Nervosa (AN), Attention Deficit Hyperactivity Disorder (ADHD), Bulimia Nervosa, Depression, Depression Acute, Diabetic Neuropathies, Insomnia, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Migraine, Moderate Depression, Neuropathic Pain, Nocturnal Enuresis, Severe Depression, Sleep disorders and disturbances, Tension Headache, Moderate Agitation, Moderate Anxiety, Severe Anxiety, Severe agitation

Associated Therapies: -

Clinical Trials

Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care

Phase 4

Not yet recruiting

Conditions: Migraine

Interventions: Drug: Topiramate
Drug: Flunarizine
Drug: Propranolol
Drug: Amitriptyline

First Posted Date: 2024-07-12

Last Posted Date: 2024-07-12

Lead Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Target Recruit Count: 460

Registration Number: NCT06499116

Comparison of Amitriptyline to Lifestyle Modification as Intervention for Vestibular Migraine

Early Phase 1

Conditions: Vestibular Migraine

Interventions: Drug: Amitriptyline

First Posted Date: 2024-05-16

Last Posted Date: 2024-06-21

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 100

Registration Number: NCT06417684

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea

Phase 2

Recruiting

Conditions: Rosacea

Interventions: Drug: Imipramine
Drug: Amitriptyline
Drug: Vehicle

First Posted Date: 2024-03-15

Last Posted Date: 2024-11-14

Lead Sponsor: Wright State University

Target Recruit Count: 48

Registration Number: NCT06312813

Locations: 🇺🇸
Wright State Physicians, Fairborn, Ohio, United States

Effect of Ketamine, Amitriptyline and Their Combination on Itch

Not Applicable

Recruiting

Conditions: Itch

Interventions: Drug: Ketamine 0.5%
Drug: Amitriptyline
Drug: ketamine + amitriptyline
Other: Vehicle
Other: Histamine
Other: Cowhage

First Posted Date: 2024-02-07

Last Posted Date: 2024-10-10

Lead Sponsor: Aalborg University

Target Recruit Count: 30

Registration Number: NCT06245564

Locations: 🇩🇰
Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University, Gistrup, Aalborg, Denmark

Efficacy of Flunarizine Vs Amitriptyline in Prophylaxis of Migraine Prophylaxis

Not Applicable

Not yet recruiting

Conditions: Migraine
Prophylaxis

Interventions: Drug: Flunarizine 5mg
Drug: Amitriptyline

First Posted Date: 2023-12-08

Last Posted Date: 2023-12-29

Lead Sponsor: Shalamar Institute of Health Sciences

Target Recruit Count: 84

Registration Number: NCT06162819

Locations: 🇵🇰
Shalamar Hospital, Lahore, Punjab, Pakistan

Responding With Evidence and Access for Childhood Headaches

Not Applicable

Recruiting

Conditions: Headache, Migraine
Migraine
Migraine Without Aura
Chronic Migraine
Headache
Headache Disorders
Migraine Disorders
Migraine With Aura

Interventions: Behavioral: CBT
Drug: Amitriptyline

First Posted Date: 2023-06-05

Last Posted Date: 2024-05-14

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 400

Registration Number: NCT05889624

Locations: 🇺🇸
Nationwide Childrens, Columbus, Ohio, United States
🇺🇸
Clinical Integrative Research Center of Atlanta, Inc, Atlanta, Georgia, United States
🇺🇸
Dent Neurological Institute, Amherst, New York, United States

and more 11 locations