Amitriptyline

Generic Name
Amitriptyline
Brand Names
Elavil
Drug Type
Small Molecule
Chemical Formula
C20H23N
CAS Number
50-48-6
Unique Ingredient Identifier
1806D8D52K
Background

Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties.

Indication

This drug in indicated for the following conditions :

Major depressive disorder in adults

Management of neuropathic pain in adults

Prophylactic treatment of chronic tension-type headache (CTTH) in adults

Prophylactic treatment of migraine in adults
...

Associated Conditions
Anorexia Nervosa (AN), Attention Deficit Hyperactivity Disorder (ADHD), Bulimia Nervosa, Depression, Depression Acute, Diabetic Neuropathies, Insomnia, Irritable Bowel Syndrome (IBS), Major Depressive Disorder (MDD), Migraine, Moderate Depression, Neuropathic Pain, Nocturnal Enuresis, Severe Depression, Sleep disorders and disturbances, Tension Headache, Moderate Agitation, Moderate Anxiety, Severe Anxiety, Severe agitation
Associated Therapies
-
Clinical Trials
Related News

A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects

Phase 1
Conditions
Depression
Interventions
Drug: Amitriptyline
First Posted Date
2015-08-10
Last Posted Date
2015-08-11
Lead Sponsor
Asan Medical Center
Target Recruit Count
24
Registration Number
NCT02519400

Newer Antidepressants in Combination With Pregabalin for Fibromyalgia Syndrome

First Posted Date
2015-05-22
Last Posted Date
2015-05-22
Lead Sponsor
Mansoura University
Target Recruit Count
75
Registration Number
NCT02451475

Trial of the Treatment of Chronic Laryngitis With Amitryptiline

First Posted Date
2015-05-05
Last Posted Date
2016-11-30
Lead Sponsor
Boston Medical Center
Target Recruit Count
30
Registration Number
NCT02434523
Locations
🇺🇸

Boston Medical Center, Boston, Massachusetts, United States

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3
Terminated
Conditions
Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders
Interventions
Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium
First Posted Date
2015-03-02
Last Posted Date
2018-02-28
Lead Sponsor
Hannover Medical School
Target Recruit Count
407
Registration Number
NCT02374567
Locations
🇩🇪

Bezirkskrankenhaus Augsburg, Augsburg, Germany

🇩🇪

Krankenhaus Hedwigshöhe, Berlin, Germany

🇩🇪

Hannover Medical School, Hannover, Germany

and more 2 locations

Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain

First Posted Date
2015-01-15
Last Posted Date
2015-10-20
Lead Sponsor
Doron Aframian
Target Recruit Count
50
Registration Number
NCT02339662
Locations
🇮🇱

Hadassah MO, Jerusalem, Israel

Genetic Determinants of Amitriptyline Efficiency for Pain Treatment - Part II

Phase 4
Completed
Conditions
Chronic Pain
Interventions
Drug: Amitriptyline
Drug: Tolterodine
First Posted Date
2014-10-06
Last Posted Date
2019-01-24
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
48
Registration Number
NCT02256956
Locations
🇨🇭

Dep. of Anesthesiology, Bern University Hospital, Bern, Switzerland

Genetic Determinants of Amitriptyline Efficiency for Pain Treatment

Phase 4
Completed
Conditions
Chronic Pain
Interventions
Drug: Amitriptyline
Drug: Tolterodine
First Posted Date
2014-10-06
Last Posted Date
2019-01-24
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Target Recruit Count
48
Registration Number
NCT02256943
Locations
🇨🇭

Dep. of Anesthesiology, Bern University Hospital, Bern, Switzerland

Study to Evaluate the Effect Single and Multiple Oral Doses of BIRT 2584 XX Tablets on the Pharmacokinetic Parameters of Amitriptyline and Nortriptyline in Healthy Male and Female Subjects

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: BIRT 2584 XX
Drug: Amitriptyline
First Posted Date
2014-10-06
Last Posted Date
2014-10-06
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
24
Registration Number
NCT02256878

Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene

First Posted Date
2014-09-12
Last Posted Date
2014-09-12
Lead Sponsor
HolsboerMaschmeyer NeuroChemie GmbH
Target Recruit Count
80
Registration Number
NCT02237937
Locations
🇩🇪

Max Planck Institute of Psychiatry, Munich, Bavaria, Germany

Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia

First Posted Date
2014-07-21
Last Posted Date
2015-03-05
Lead Sponsor
CAMC Health System
Target Recruit Count
60
Registration Number
NCT02195115
Locations
🇺🇸

Charleston Area Medical Center, Charleston,, West Virginia, United States

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