Diphenhydramine

Generic Name: Diphenhydramine

Brand Names: Acetadryl, Advil PM, Aleve PM, Allegra Cooling Relief Anti-itch, Banophen, Benadryl, Benadryl Itch Stopping, Benadryl-D Allergy and Sinus, Calagel, Damylin With Codeine, Dimetapp Nighttime Cold & Congestion, Diphen, Diphenhist, Diphenist, Excedrin PM Triple Action, Goody's PM, Legatrin PM, Motrin PM, Nytol, Nytol Quickgels, Percogesic Reformulated Jan 2011, Siladryl, Simply Sleep, Sleepinal, Sominex, Triaminic Night Time Cold & Cough, Tylenol PM, Unisom, Unisom Sleep, Vanamine, Wal-dryl, Wal-som (doxylamine), Zzzquil

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₁NO

CAS Number: 58-73-1

Unique Ingredient Identifier: 8GTS82S83M

Background: Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes . However, it also has antiemetic, antitussive, hypnotic, and antiparkinson properties . As histamine receptors exist both ...

Indication: Diphenhydramine is a first-generation histamine H1 receptor antagonist (H1 antihistamine) that is widely available as a non-prescription, over-the-counter (OTC) medication. As an OTC medication, diphenhydramine is typically formulated as tablets and creams indicated for use in treating sneezing, runny nose, itchy/watery eyes, itching of nose or throat, insom...

Associated Conditions: Allergic Reaction, Allergic Rhinitis (AR), Allergic cough, Allergy to Tree Pollen, Anaphylaxis, Angioedema, Common Cold, Conjunctival irritation, Cough, Cough Variant Asthma, Cough caused by Common Cold, Eye allergy, Fever, Insect Bites, Insect Stings, Insomnia, Irritative cough, Itching of the nose, Itching of the throat, Motion Sickness, Nasal Congestion, Oral Mucositis, Pain, Parkinsonian Syndromes, Productive cough, Pruritus, Rash, Rhinorrhoea, Sinus Congestion, Sinus headache, Skin Irritation, Sneezing, Sunburn, Symptoms of Acute Bronchitis Accompanied by Coughing, Upper respiratory tract hypersensitivity reaction, site unspecified, Urticaria, Cold or flu syndrome, Dermatographism, Dry cough, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Expectorant

Clinical Trials

Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia

Phase 2

Active, not recruiting

Conditions: Hairy Cell Leukemia

Interventions: Drug: Rituximab
Drug: Pentostatin
Drug: Bendamustine
Drug: Acetaminophen
Drug: Diphenhydramine
Drug: Epinephrine
Drug: Antihistamines
Drug: Corticosteroids
Drug: Bronchodilators
Other: Intravenous (IV) Saline

First Posted Date: 2010-02-01

Last Posted Date: 2024-05-01

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 69

Registration Number: NCT01059786

Locations: 🇺🇸
National Institutes of Health Clinical Center, Bethesda, Maryland, United States

Study of Ramucirumab (IMC-1121B) Therapy and Corrected QT (QTc) Interval Changes

Phase 2

Completed

Conditions: Cancer
Solid Tumor

Interventions: Biological: IMC-1121B
Drug: Moxifloxacin
Drug: Diphenhydramine

First Posted Date: 2009-11-23

Last Posted Date: 2015-06-10

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 68

Registration Number: NCT01017731

Locations: 🇺🇸
ImClone Investigational Site, Seattle, Washington, United States

Study on the Development of Opioid Induced Hyperalgesia (OIH) After Exposure to Alfentanil

Not Applicable

Completed

Conditions: Hyperalgesia

Interventions: Drug: Alfentanil
Drug: Diphenhydramine

First Posted Date: 2009-10-08

Last Posted Date: 2017-10-06

Lead Sponsor: Johns Hopkins University

Target Recruit Count: 22

Registration Number: NCT00991809

Locations: 🇺🇸
Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Chicago Social Drinking Project

Not Applicable

Recruiting

Conditions: Alcoholism

Interventions: Drug: Placebo
Drug: Diphenhydramine
Drug: Ethanol
Drug: Caffeine

First Posted Date: 2009-08-19

Last Posted Date: 2024-01-29

Lead Sponsor: University of Chicago

Target Recruit Count: 800

Registration Number: NCT00961792

Locations: 🇺🇸
Clinical Addictions Research Laboratory, Chicago, Illinois, United States

Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures

Phase 4

Completed

Conditions: Endoscopic Retrograde Cholangiopancreatography (ERCP)
Endoscopic Ultrasound (EUS)

Interventions: Drug: Meperidine, Midazolam
Drug: Diphenhydramine
Drug: Promethazine

First Posted Date: 2009-07-13

Last Posted Date: 2024-02-26

Lead Sponsor: University of California, Irvine

Target Recruit Count: 304

Registration Number: NCT00937924

Locations: 🇺🇸
H.H. Chao Comprehensive Digestive Disease Center, Orange, California, United States

Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood

Phase 1

Completed

Conditions: Leukemia, Acute Myelogenous (AML)
Leukemia, Acute Lymphocytic (ALL)
Myelodysplastic Syndrome (MDS)
Non-Hodgkin's Lymphoma (NHL)
Leukemia, Chronic Myelogenous (CML)

Interventions: Drug: Donor Lymphocytes
Drug: WT1 Peptide-Pulsed Dendritic Cells
Drug: Diphenhydramine
Drug: IL-4
Drug: KLH
Drug: WT1 Peptides
Drug: Endotoxin
Drug: Acetaminophen

First Posted Date: 2009-06-18

Last Posted Date: 2017-04-12

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 10

Registration Number: NCT00923910

Locations: 🇺🇸
National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Phase 2 Study of Autologous Followed by Nonmyeloablative Allogeneic Transplantation Using TLI & ATG

Phase 2

Completed

Conditions: Transplantation, Autologous
Multiple Myeloma
Blood and Marrow Transplant (BMT)
Transplantation, Homologous

Interventions: Procedure: Autologous peripheral blood stem cells (auto-PBSC) transplantation
Procedure: Allogeneic peripheral blood stem cells (allo-PBSC) transplantation
Drug: Filgrastim
Drug: Cyclophosphamide
Drug: Melphalan
Drug: Cyclosporine
Radiation: Total lymphoid irradiation
Biological: Rabbit anti-thymocyte globulin
Drug: Mycophenolate Mofetil 250mg
Drug: Solumedrol
Drug: Diphenhydramine
Drug: Acetaminophen
Drug: Hydrocortisone

First Posted Date: 2009-05-12

Last Posted Date: 2017-10-20

Lead Sponsor: Stanford University

Target Recruit Count: 9

Registration Number: NCT00899847

Locations: 🇺🇸
Stanford University School of Medicine, Stanford, California, United States

Impact of Temsirolimus Therapy on Circulating Tumor Cell Biology In Men With Castration Resistant Metastatic Prostate Cancer

Phase 2

Terminated

Conditions: Prostate Cancer

Interventions: Drug: Temsirolimus
Drug: Diphenhydramine

First Posted Date: 2009-04-24

Last Posted Date: 2014-02-26

Lead Sponsor: Duke University

Target Recruit Count: 11

Registration Number: NCT00887640

Locations: 🇺🇸
Virginia Oncology Associates, Norfolk, Virginia, United States
🇺🇸
Duke University Medical Center, Durham, North Carolina, United States