Tobramycin
- Generic Name
- Tobramycin
- Brand Names
- Bethkis, Kitabis, Tobi, Tobi Podhaler Weekly Kit, Tobradex, Tobrex, Zylet, Tobi Podhaler, Vantobra (previously Tobramycin PARI)
- Drug Type
- Small Molecule
- Chemical Formula
- C18H37N5O9
- CAS Number
- 32986-56-4
- Unique Ingredient Identifier
- VZ8RRZ51VK
- Background
Aminoglycosides, many of which are derived directly from Streptomyces spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is notable for its use in treating chronic Pseudomonas aeruginosa infections in cystic fibrosis patients, as P. aeruginosa is n...
- Indication
Inhaled tobramycin is indicated for the management of cystic fibrosis patients with Pseudomonas aeruginosa, but is not recommended in patients under six years of age, those with forced expiratory volume in 1 second (FEV) <25 or >80% predicted, or in those with Burkholderia cepacia.
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- Associated Conditions
- Bacterial Peritonitis, Bone Infection, Cystic fibrosis, Pseudomonas aeruginosa infection, Eye Infections, Inflammation of the External Auditory Canal, Intraabdominal Infections, Lower respiratory tract infection bacterial, Meningitis, Bacterial, Ocular Inflammation, Septicemia gram-negative, Skin and Subcutaneous Tissue Bacterial Infections, Corticosteroid-responsive Disorder of the Ophthalmic, Ear infection-not otherwise specified caused by susceptible bacteria, Ocular bacterial infections, Recurrent Complicated Urinary Tract Infection, Steroid-responsive inflammation
- Associated Therapies
- -
Antibiotic Loaded Cement After TKA
- Conditions
- Interventions
- First Posted Date
- 2022-06-23
- Last Posted Date
- 2024-04-30
- Lead Sponsor
- Rothman Institute Orthopaedics
- Target Recruit Count
- 50
- Registration Number
- NCT05429671
- Locations
- 🇺🇸
Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States
Effect of Various Treatment Modalities on Dendritic Vial Ulcer
- Conditions
- Interventions
- First Posted Date
- 2022-04-06
- Last Posted Date
- 2022-04-06
- Lead Sponsor
- Sohag University
- Target Recruit Count
- 40
- Registration Number
- NCT05313828
- Locations
- 🇪🇬
Sohag University, Sohag, Egypt
Acute Application of Antibiotic Powder in Open Fracture Wounds
- First Posted Date
- 2021-05-04
- Last Posted Date
- 2024-02-05
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 20
- Registration Number
- NCT04872400
- Locations
- 🇺🇸
University of Colorado Anschutz, Aurora, Colorado, United States
🇺🇸Denver Health and Hospital Authority, Denver, Colorado, United States
Tobramycin Administered at the Beginning of Dialysis
- First Posted Date
- 2019-04-05
- Last Posted Date
- 2021-02-26
- Lead Sponsor
- Maisonneuve-Rosemont Hospital
- Target Recruit Count
- 11
- Registration Number
- NCT03904836
- Locations
- 🇨🇦
Maisonneuve-Rosemont Hospital, Montréal, Quebec, Canada
Locally Applied Antibiotics for Infection Prophylaxis in Treatment of Open Fractures
- First Posted Date
- 2018-10-15
- Last Posted Date
- 2023-06-15
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 11
- Registration Number
- NCT03705962
- Locations
- 🇺🇸
University of Virginia Medical Center, Charlottesville, Virginia, United States
Topical Antibiotics in Chronic Rhinosinusitis
- Conditions
- Interventions
- First Posted Date
- 2018-09-17
- Last Posted Date
- 2022-04-20
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 19
- Registration Number
- NCT03673956
- Locations
- 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
DPI-Tobra-Kind Cyclops® in Children With Cystic Fibrosis
- First Posted Date
- 2018-04-02
- Last Posted Date
- 2021-10-01
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 10
- Registration Number
- NCT03485456
- Locations
- 🇳🇱
University Medical Center Groningen, Groningen, Netherlands
Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection
- Conditions
- Interventions
- First Posted Date
- 2017-10-12
- Last Posted Date
- 2018-07-19
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 60
- Registration Number
- NCT03308253
- Locations
- 🇨🇦
Hamilton General Hospital, Hamilton, Ontario, Canada
Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis
- First Posted Date
- 2017-02-28
- Last Posted Date
- 2021-09-05
- Lead Sponsor
- University Hospital, Lille
- Target Recruit Count
- 23
- Registration Number
- NCT03066453
- Locations
- 🇫🇷
CRCM mixte - CH de Dunkerque, Dunkerque, France
🇫🇷CRCM mixte - CHU de Caen Hôpital Côte de Nacre, Caen, France
🇫🇷CRCM pédiatrique - CHU d'Amiens Hôpital Nord, Amiens, France
IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy
- First Posted Date
- 2016-09-29
- Last Posted Date
- 2023-04-21
- Lead Sponsor
- National Jewish Health
- Target Recruit Count
- 51
- Registration Number
- NCT02918409
- Locations
- 🇺🇸
National Jewish Health, Denver, Colorado, United States
Drug Development Updates
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