Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Intraoperative Transversus Abdominis Plane Block for Gynecologic Surgery (GYNTAP)

Phase 3

Withdrawn

Conditions: Postoperative Nausea and Vomiting
Postoperative Pain

Interventions: Other: Placebo
Drug: Ropivacaine
Procedure: Transversus Abdominis Plane Block

First Posted Date: 2015-07-23

Last Posted Date: 2016-05-13

Lead Sponsor: University of Mississippi Medical Center

Registration Number: NCT02506855

Locations: 🇺🇸
University of Mississippi Medical Center, Jackson, Mississippi, United States

Dorsal Penile Nerve Block for Rigid Cystoscopy in Men

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Tetracaine
Procedure: Dorsal Penile Nerve Block
Drug: Ropivacaine

First Posted Date: 2015-07-20

Last Posted Date: 2020-03-31

Lead Sponsor: West China Hospital

Target Recruit Count: 258

Registration Number: NCT02502487

Locations: 🇨🇳
West China Hospital of Sichuan University, Department of Anesthesiology, Chengdu, Sichuan, China

Trans-incisional vs Laparoscopic Guided Rectus Sheath Block for Pediatric Single Incision Laparoscopic Cholecystectomy

Not Applicable

Completed

Conditions: Pain, Postoperative

Interventions: Procedure: Trans-incisional rectus sheath block
Procedure: Laparoscopic guided rectus sheath block
Drug: Ropivacaine

First Posted Date: 2015-07-10

Last Posted Date: 2021-01-22

Lead Sponsor: Johns Hopkins All Children's Hospital

Target Recruit Count: 48

Registration Number: NCT02494336

Locations: 🇺🇸
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States

Does Perineural Dexmedetomidine Prolong Duration of a Nerve Block?

Phase 2

Completed

Conditions: Healthy

Interventions: Drug: Ropivacaine
Drug: Dexmedetomidine
Drug: Isotonic Saline

First Posted Date: 2015-07-02

Last Posted Date: 2016-01-05

Lead Sponsor: Zealand University Hospital

Target Recruit Count: 21

Registration Number: NCT02488473

Locations: 🇩🇰
Department of Anesthesiology Koege Hospital, Koege, Denmark

Fascia Iliaca Compartment Block in Acute and Chronic Pain Management in Hip Fracture Patients

Not Applicable

Completed

Conditions: Chronic Hip Pain

Interventions: Drug: Fascia iliaca compartment block
Drug: Placebo
Drug: Ropivacaine
Device: ultrasound

First Posted Date: 2015-06-24

Last Posted Date: 2019-03-12

Lead Sponsor: Asklepieion Voulas General Hospital

Target Recruit Count: 198

Registration Number: NCT02479828

Locations: 🇬🇷
Asklepieion General Hospital, Athens, Voula, Greece

Analgesic Effects of US Bilateral Rectus Sheath Block for Laparoscopic GY Surgery

Not Applicable

Completed

Conditions: Gynecologic Disease

Interventions: Procedure: Rectus sheath block
Drug: Ropivacaine
Other: Bandage
Drug: IV-PCA containing Fentanyl and Ketorolac

First Posted Date: 2015-06-19

Last Posted Date: 2015-06-19

Lead Sponsor: Ewha Womans University Mokdong Hospital

Target Recruit Count: 60

Registration Number: NCT02476799

Locations: 🇰🇷
Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of

Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks

Phase 4

Completed

Conditions: Full-thickness Rotator Cuff Tear

Interventions: Procedure: Arthroscopic Rotator Cuff Repair
Drug: Saline
Drug: Ropivacaine

First Posted Date: 2015-06-04

Last Posted Date: 2020-12-22

Lead Sponsor: Orlando Health, Inc.

Target Recruit Count: 51

Registration Number: NCT02462382

Locations: 🇺🇸
Orlando Orthopaedic Center, Orlando, Florida, United States

The Effects of TAP Block on Postsurgical Pain After Minimally Invasive Partial Nephrectomy:

Not Applicable

Completed

Conditions: Chronic Pain
Acute Pain

Interventions: Procedure: intravenous Patient controlled analgesia
Procedure: Tap block
Drug: Morphine
Drug: Ropivacaine

First Posted Date: 2015-06-02

Last Posted Date: 2018-02-05

Lead Sponsor: Regina Elena Cancer Institute

Target Recruit Count: 96

Registration Number: NCT02460640

Locations: 🇮🇹
Regina Elena CI, Rome, Italy

The Effect of the Serratus Block on Pain Control After Breast Surgery

Phase 2

Completed

Conditions: Anesthesia

Interventions: Procedure: Serratus Block
Procedure: Placebo Block
Other: sterile saline
Drug: ropivacaine
Drug: epinephrine

First Posted Date: 2015-05-25

Last Posted Date: 2020-01-13

Lead Sponsor: Women's College Hospital

Target Recruit Count: 40

Registration Number: NCT02453516

Locations: 🇨🇦
Women's College Hospital, Toronto, Ontario, Canada

Ultrasound-guided Bilateral Rectus Sheath Block for Robotic Single-port Gynecologic Surgery

Not Applicable

Completed

Conditions: Gynecologic Disease

Interventions: Procedure: Rectus sheath block
Drug: Ropivacaine
Other: Bandage
Drug: IV-PCA containing Fentanyl

First Posted Date: 2015-05-21

Last Posted Date: 2017-02-08

Lead Sponsor: Ewha Womans University Mokdong Hospital

Target Recruit Count: 60

Registration Number: NCT02450084

Locations: 🇰🇷
Ewha Womans University Mokdong Hospital, Seoul, Korea, Republic of

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy