Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Nebulized Analgesia for Laparoscopic Appendectomy Trial

Phase 1

Conditions: Appendicitis

Interventions: Drug: Normal saline
Drug: Ropivacaine

First Posted Date: 2015-12-08

Last Posted Date: 2016-03-22

Lead Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Target Recruit Count: 200

Registration Number: NCT02624089

Locations: 🇨🇦
Montreal Children's Hospital, Montreal, Quebec, Canada

Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks

Phase 4

Completed

Conditions: Post-thoracotomy Pain Syndrome

Interventions: Drug: Ropivacaine
Drug: Dexmedetomidine
Device: Mindray M7 series

First Posted Date: 2015-12-02

Last Posted Date: 2015-12-02

Lead Sponsor: Weifeng Tu

Target Recruit Count: 60

Registration Number: NCT02619513

Locations: 🇨🇳
Department of Anesthesiology，Guangzhou Military Region General Hospital, Guangzhou, Guangdong, China

Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty

Not Applicable

Conditions: Knee Osteoarthritis

Interventions: Drug: Ropivacaine
Drug: Exparel

First Posted Date: 2015-11-18

Last Posted Date: 2017-04-27

Lead Sponsor: Monmouth Medical Center

Target Recruit Count: 200

Registration Number: NCT02607579

Locations: 🇺🇸
Monmouth Medical Center, Long Branch, New Jersey, United States

Exparel Infiltration in Anterior Cruciate Ligament Reconstruction

Phase 4

Completed

Conditions: Pain

Interventions: Procedure: Femoral nerve block
Drug: Liposomal bupivacaine
Drug: Ropivacaine

First Posted Date: 2015-11-17

Last Posted Date: 2023-12-08

Lead Sponsor: Henry Ford Health System

Target Recruit Count: 84

Registration Number: NCT02606448

Adductor Canal Catheter vs Local Infiltration of Analgesia for Total Knee Arthroplasty

Phase 4

Withdrawn

Conditions: Acute Pain
Regional Anesthesia Morbidity

Interventions: Drug: bupivacaine
Drug: ropivacaine
Device: Adductor Canal Catheter
Device: Sham Adductor Canal Catheter

First Posted Date: 2015-11-13

Last Posted Date: 2021-12-15

Lead Sponsor: Thomas Jefferson University

Registration Number: NCT02603900

Locations: 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Analgesic Efficacy of Transmuscular Quadratus Lumborum in Patients Undergoing Total Abdominal Hysterectomy

Not Applicable

Completed

Conditions: Pain Postoperative

Interventions: Drug: morphine
Procedure: Transmuscular quadratus lumborum block
Drug: ropivacaine

First Posted Date: 2015-10-26

Last Posted Date: 2017-06-20

Lead Sponsor: Kuala Lumpur General Hospital

Target Recruit Count: 64

Registration Number: NCT02586454

Locations: 🇲🇾
Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

Effect of Local Infiltration Anesthesia With Ropivacaine on Postoperative Pain After Hip Hemiarthroplasty

Not Applicable

Completed

Conditions: Femoral Neck Fractures

Interventions: Drug: Saline
Drug: Ropivacaine
Drug: Epinephrine

First Posted Date: 2015-10-23

Last Posted Date: 2020-09-11

Lead Sponsor: St. Olavs Hospital

Target Recruit Count: 123

Registration Number: NCT02585011

Locations: 🇳🇴
Ortopedisk forskningssenter, St.Olavs Hospital, Trondheim, Norway

Magnesium Sulfate in Adductor Canal Blocks

Phase 4

Completed

Conditions: Knee Arthroplasty

Interventions: Other: Sham
Drug: Magnesium Sulfate
Drug: Ropivacaine

First Posted Date: 2015-10-21

Last Posted Date: 2020-11-13

Lead Sponsor: Queen's University

Target Recruit Count: 130

Registration Number: NCT02581683

Locations: 🇨🇦
Kingston General Hospital, Kingston, Ontario, Canada
🇨🇦
Hotel Dieu Hospital, Kingston, Ontario, Canada

The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty

Not Applicable

Conditions: Pain Management
Sedation
Peripheral Nerve Block
Total Knee Arthroplasty

Interventions: Procedure: peri-operative continuous femoral nerve block with light sedation
Procedure: post-operative continuous femoral nerve block
Drug: lidocaine
Device: ultrasound
Drug: saline
Device: insulated needle (Contiplex B Braun, Melsungen, Germany)
Drug: ropivacaine

First Posted Date: 2015-10-15

Last Posted Date: 2015-10-15

Lead Sponsor: Min Su

Target Recruit Count: 380

Registration Number: NCT02576015

Locations: 🇨🇳
The Department of Anesthesiology,the first Affiliated Hospital of Chongqing Medical University, Chonqqing, Chongqing, China

Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis

Phase 4

Completed

Conditions: Osteoarthritis

Interventions: Drug: Ropivacaine
Drug: Normal saline
Drug: Methylprednisolone

First Posted Date: 2015-10-15

Last Posted Date: 2017-08-21

Lead Sponsor: Mayo Clinic

Target Recruit Count: 29

Registration Number: NCT02576249

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

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