Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Suprascapular Nerve Block as Postoperative Analgesia After Artroscopic Shoulder Surgery

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Ropivacaine hydrochloride
Drug: Isotonic Saline
Drug: PCA-pump

First Posted Date: 2015-10-15

Last Posted Date: 2024-03-21

Lead Sponsor: Kai Henrik Wiborg Lange

Target Recruit Count: 40

Registration Number: NCT02576223

Locations: 🇩🇰
Holbæk Sygehus, Holbæk, Denmark
🇩🇰
Nordsjællands Hospital, Hillerød, Denmark

Liposomal Bupivacaine in Total Shoulder Arthroplasty

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Liposomal bupivacaine
Procedure: Inter-scalene nerve block
Drug: Ropivacaine

First Posted Date: 2015-10-07

Last Posted Date: 2016-10-13

Lead Sponsor: Henry Ford Health System

Target Recruit Count: 57

Registration Number: NCT02570022

Locations: 🇺🇸
Henry Ford Health System, Detroit, Michigan, United States

Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

Phase 4

Terminated

Conditions: Osteoarthritis, Knee

Interventions: Drug: 0.9% sodium chloride
Drug: Ropivacaine
Drug: Ketorolac
Drug: Clonidine
Drug: Epinephrine

First Posted Date: 2015-10-07

Last Posted Date: 2022-03-04

Lead Sponsor: Virginia Commonwealth University

Target Recruit Count: 64

Registration Number: NCT02570503

Locations: 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States

Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery

Not Applicable

Completed

Conditions: Spinal Anesthesia

Interventions: Procedure: Intervertebral space
Drug: Ropivacaine

First Posted Date: 2015-10-01

Last Posted Date: 2018-03-01

Lead Sponsor: Shanghai 6th People's Hospital

Target Recruit Count: 60

Registration Number: NCT02565303

Locations: 🇨🇳
Shanghai Sixth People's Hospital, Shanghai, Shanghai, China

Location of Injection of Local Anesthetics in the Adductor Canal Block

Not Applicable

Completed

Conditions: Anesthesia
Adductor Canal Block

Interventions: Drug: lidocaine
Drug: ropivacaine

First Posted Date: 2015-09-18

Last Posted Date: 2019-02-27

Lead Sponsor: Women's College Hospital

Target Recruit Count: 108

Registration Number: NCT02554864

Locations: 🇨🇦
Women's College Hospital, Toronto, Ontario, Canada

A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty

Phase 4

Completed

Conditions: Total Hip and Knee Arthroplasty

Interventions: Drug: Liposomal Bupivacaine
Drug: Ropivacaine
Drug: Bupivacaine
Drug: Clonidine
Drug: Epinephrine
Drug: Ketorolac

First Posted Date: 2015-09-07

Last Posted Date: 2019-10-18

Lead Sponsor: Kootenai Health

Target Recruit Count: 239

Registration Number: NCT02543801

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Phase 3

Conditions: Osteoarthritis
Knee Arthroplasty
Pain Management

Interventions: Procedure: Periarticular
Procedure: Motor free
Procedure: Motor free with dex
Drug: Ropivacaine
Drug: epinephrine
Drug: morphine
Drug: Ketorolac
Drug: Dexmedetomidine
Drug: saline

First Posted Date: 2015-09-03

Last Posted Date: 2016-11-15

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 135

Registration Number: NCT02540070

Locations: 🇨🇦
University Hospital, London Health Sciences Centre, London, Ontario, Canada

Continues Cicatricial Perfusion of Ropivacaine Versus Placebo After Mastectomy : Rehabilitation After Treatment

Phase 3

Terminated

Conditions: Breast Cancer

Interventions: Drug: physiological saline
Drug: Ropivacaine

First Posted Date: 2015-08-17

Last Posted Date: 2018-08-13

Lead Sponsor: Institut Paoli-Calmettes

Target Recruit Count: 59

Registration Number: NCT02525211

Locations: 🇫🇷
Daniel FRANCON, Marseille, France

Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia

Not Applicable

Completed

Conditions: Pain Insensitivity, Congenital

Interventions: Drug: Bupivacaine
Drug: Ropivacaine
Drug: Levobupivacaine

First Posted Date: 2015-07-31

Last Posted Date: 2015-08-04

Lead Sponsor: Government Medical College, Haldwani

Target Recruit Count: 90

Registration Number: NCT02513433

Locations: 🇮🇳
Government Medical College, Haldwani, Uttarakhand, India

The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block

Not Applicable

Completed

Conditions: Supraclavicular Brachial Plexus Block

Interventions: Drug: Ropivacaine

First Posted Date: 2015-07-31

Last Posted Date: 2016-02-19

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 114

Registration Number: NCT02512471

Locations: 🇨🇳
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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