Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Analgesic Efficacy of Perineural Dexamethasone During Supraclavicular Block for Hand Surgery

Phase 2

Terminated

Conditions: Surgery, Hand

Interventions: Drug: Ropivacaine
Other: Placebo
Drug: Dexamethasone

First Posted Date: 2014-06-03

Last Posted Date: 2014-09-11

Lead Sponsor: Duke University

Target Recruit Count: 5

Registration Number: NCT02154048

A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block

Completed

Conditions: Upper Extremity Surgery

Interventions: Drug: Ropivacaine
Drug: Ropivacaine and dexamethasone
Drug: Ropivacaine and clonidine
Drug: Ropivacaine, dexamethasone and clonidine

First Posted Date: 2014-05-30

Last Posted Date: 2019-07-05

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 97

Registration Number: NCT02151487

Locations: 🇺🇸
Parkland Health Hospital System, Dallas, Texas, United States

Prevention of Myocardial Dysfunction and Injury Resulting From Salter Innominate Osteotomy by Caudal Block

Phase 4

Conditions: Cardiac Dysfunction
Myocardial Injury

Interventions: Drug: saline
Drug: ropivacaine

First Posted Date: 2014-05-22

Last Posted Date: 2014-08-26

Lead Sponsor: Si-Qin Chen

Target Recruit Count: 40

Registration Number: NCT02144766

Locations: 🇨🇳
Xinhua Hospital, Shanghai, China

The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance

Phase 1

Completed

Conditions: Upper Limb Nerve Block

Interventions: Procedure: specific nerve block
Drug: ropivacaine

First Posted Date: 2014-05-16

Last Posted Date: 2014-08-01

Lead Sponsor: Wenzhou Medical University

Target Recruit Count: 110

Registration Number: NCT02139982

Locations: 🇨🇳
The Second Affiliated Hospital & Yuying Children hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Horner's SD After Thoracic Epidural Block

Completed

Conditions: Horner's Syndrome

Interventions: Procedure: thoracic epidural anesthesia
Procedure: mastectomy
Drug: Ropivacaine
Drug: Propofol
Drug: Fentanyl

First Posted Date: 2014-05-05

Last Posted Date: 2014-05-05

Lead Sponsor: Soonchunhyang University Hospital

Target Recruit Count: 450

Registration Number: NCT02130739

Locations: 🇰🇷
Soonchunhyang University Seoul Hospital, Seoul, Korea, Republic of

Comparison of Continuous Femoral Nerve Block and Adductor Canal Block After Total Knee Replacement Therapy

Not Applicable

Completed

Conditions: Total Knee Arthroplasty
Total Knee Replacement
Adductor Canal Block
Femoral Nerve Block

Interventions: Drug: Ropivacaine

First Posted Date: 2014-04-29

Last Posted Date: 2015-01-26

Lead Sponsor: Philipps University Marburg Medical Center

Target Recruit Count: 44

Registration Number: NCT02125903

Locations: 🇩🇪
University of Marburg Department of Anaesthesia And Intensive Care Medicine, Marburg, Germany

Comparison of Two Kinds of Postoperative Analgesia After Amputation

Phase 4

Conditions: Complications
Pain

Interventions: Procedure: Intravenous analgesic
Procedure: Local analgesic
Drug: ropivacaine
Drug: flurbiprofen

First Posted Date: 2014-04-15

Last Posted Date: 2015-03-12

Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Target Recruit Count: 36

Registration Number: NCT02114463

Locations: 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China

Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty

Phase 4

Conditions: Pain
Complications

Interventions: Procedure: Local analgesic
Procedure: Nerve Block
Procedure: Intravenous analgesic
Drug: ropivacaine
Drug: opioid

First Posted Date: 2014-03-21

Last Posted Date: 2015-03-12

Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Target Recruit Count: 45

Registration Number: NCT02094339

Locations: 🇨🇳
Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China

Comparison of Different Methods of Pain Control After Cesarean Section for Patients on Buprenorphine or Methadone

Not Applicable

Withdrawn

Conditions: Caesarean Delivery

Interventions: Drug: TAP Block
Drug: Ropivacaine
Drug: Morphine
Drug: Acetaminophen

First Posted Date: 2014-03-19

Last Posted Date: 2016-08-05

Lead Sponsor: Dartmouth-Hitchcock Medical Center

Registration Number: NCT02091297

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
🇺🇸
Brigham & Women's Hospital, Boston, Massachusetts, United States

Does the Use of Ropivacaine Facilitates Cholecystectomy by Laparoscopy in Ambulatory Surgery?

Phase 4

Completed

Conditions: Cholecystectomy
Laparoscopy

Interventions: Drug: Ropivacaine

First Posted Date: 2014-03-13

Last Posted Date: 2015-05-19

Lead Sponsor: Centre Hospitalier Departemental Vendee

Target Recruit Count: 120

Registration Number: NCT02085902

Locations: 🇫🇷
Centre hospitalier départemental Vendée, La Roche sur Yon, France

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