Acetaminophen

Generic Name: Acetaminophen

Brand Names: Acephen, Acetadryl, Allzital, Apadaz, Arthriten Inflammatory Pain, Bupap, Butapap, Cetafen, Children's Silapap, Coricidin Hbp Cold & Flu, Darvocet-N, Dayquil Sinex, Diphen, Dolofin, Dologen, Dologesic Reformulated Jun 2016, Duralgina, Dvorah, Endocet, Esgic, Exaprin, Excedrin, Excedrin PM Triple Action, Excedrin Tension Headache, Feverall, Fioricet, Fioricet With Codeine, Goody's Back & Body Pain Relief, Goody's Body Pain, Goody's Extra Strength, Goody's Headache Relief Shot, Goody's PM, Hycet, Legatrin PM, Little Fevers, Lorcet, Lortab, Mapap, Mersyndol, Midol Complete, Midol Cramps & Bodyaches, Nalocet, Norco, Orbivan, Pamprin Max Formula, Pamprin Multi-symptom, Panadol, Pediacare Children's Fever Reducer Pain Reliever, Percocet, Percogesic Reformulated Jan 2011, Pharbetol, Premsyn Pms, Prolate, Rivacocet, Robaxacet, Robaxacet-8, Roxicet, Sudafed PE Sinus Headache, Tactinal, Tencon, Trezix, Triatec, Triatec-30, Triatec-8, Tylenol, Tylenol PM, Tylenol With Codeine, Ultracet, Vanatol, Vanatol S, Vanquish, Xodol, Xolox, Zamicet, Zflex, Zydone

Drug Type: Small Molecule

Chemical Formula: C_₈H_₉NO_₂

CAS Number: 103-90-2

Unique Ingredient Identifier: 362O9ITL9D

Background: Acetaminophen (paracetamol), also commonly known as Tylenol, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the U.S. FDA in 1951 and is available in a var...

Indication: In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms.
...

Associated Conditions: Acute Gouty Arthritis, Acute Musculoskeletal Pain, Allergic Reaction, Allergy to Tree Pollen, Ankylosing Spondylitis (AS), Chills, Cold, Common Cold, Cough, Cough caused by Common Cold, Coughing caused by Flu caused by Influenza, Dyskinesia of the Biliary Tract, Dyskinesia of the Urinary Tract, Febrile Convulsions, Febrile Illness Acute, Fever, Fibromyalgia, Flu caused by Influenza, Headache, Joint dislocations, Menstrual Distress (Dysmenorrhea), Mild pain, Muscle Inflammation, Muscle Injuries, Muscle Spasms, Musculoskeletal Pain, Myalgia, Nasal Congestion, Neuropathic Pain, Osteoarthritis (OA), Pain, Postoperative pain, Premenstrual cramps, Rheumatoid Arthritis, Rhinopharyngitis, Rhinorrhoea, Severe Pain, Sinusitis, Spasms, Spastic Pain of the Gastrointestinal Tract, Sprains, Symptoms Cold, Tension Headache, Toothache, Upper Respiratory Tract Infection, Whiplash Syndrome, Acute Torticollis, Articular inflammation, Cold or flu syndrome, Mild to moderate pain, Minor aches and pains, Minor pain, Moderate Pain, Moderate to severe pain

Associated Therapies: Airway secretion clearance therapy, Anti-spasmodics, Bronchodilation

Clinical Trials

Opioid-Free Pain Protocol After Shoulder Arthroplasty

Phase 4

Recruiting

Conditions: Shoulder Arthropathy
Shoulder Pain

Interventions: Drug: Celecoxib
Drug: Pregabalin
Drug: Tramadol
Drug: Dexamethasone
Drug: Acetaminophen
Drug: Ropivicaine
Drug: Epinephrine
Drug: Ketorolac
Drug: Tizanidine
Drug: Magnesium
Drug: Ibuprofen
Drug: Oxycodone Hydrochloride 5 Mg

First Posted Date: 2022-08-05

Last Posted Date: 2024-01-12

Lead Sponsor: Henry Ford Health System

Target Recruit Count: 80

Registration Number: NCT05488847

Locations: 🇺🇸
Henry Ford Health, Detroit, Michigan, United States

Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients

Phase 3

Completed

Conditions: COVID-19 Respiratory Infection
FLU
Cold; Influenza
Bacterial Pneumonia
COVID-19 Pneumonia

Interventions: Dietary Supplement: Kunamin®
Drug: Favipiravir
Drug: Enoxaparin
Drug: Lansoprazole
Drug: Paracetamol
Drug: Ceftriaxone/ Clarithromycin
Drug: Methylprednisolone

First Posted Date: 2022-06-14

Last Posted Date: 2022-06-14

Lead Sponsor: RAAS Nutritionals, LLC

Target Recruit Count: 71

Registration Number: NCT05417997

Locations: 🇹🇷
Kayseri City Hospital, Kayseri, Kayseri Province, Turkey

Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery

Phase 4

Completed

Conditions: Pain Management
Posterior Spinal Fusion

Interventions: Drug: Morphine
Drug: Toradol
Drug: Orphenadrine
Drug: Gabapentin
Drug: Acetaminophen
Drug: Bupivacaine
Drug: Epinephrine
Drug: Xylocaine Injectable Solution
Drug: Methylprednisolone

First Posted Date: 2022-06-10

Last Posted Date: 2022-06-10

Lead Sponsor: University of Puerto Rico

Target Recruit Count: 100

Registration Number: NCT05413902

Locations: 🇵🇷
Puerto Rico Medical Center - University District Hospital, San Juan, Puerto Rico

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery

Not Applicable

Completed

Conditions: Postoperative Pain Management

Interventions: Drug: Tramadol
Drug: Paracetamol
Drug: Ibuprofen

First Posted Date: 2022-06-02

Last Posted Date: 2023-08-18

Lead Sponsor: Bezmialem Vakif University

Target Recruit Count: 2

Registration Number: NCT05401916

Locations: 🇹🇷
Muhittin Calim, Istanbul, Fatih, Turkey

The Effects of Acetaminophen on Fear

Not Applicable

Conditions: Fear

Interventions: Other: Placebo
Drug: Acetaminophen

First Posted Date: 2022-05-31

Last Posted Date: 2022-05-31

Lead Sponsor: University of Guelph

Target Recruit Count: 266

Registration Number: NCT05396677

Locations: 🇨🇦
University of Guelph, Guelph, Ontario, Canada

Ketorolac-an Option for Post Operative Pain Management After Elective Cardiac Surgery.

Phase 4

Completed

Conditions: Coronary Artery Disease
Post Operative Pain
Analgesia
Coronary Artery Bypass Grafting Surgery

Interventions: Drug: Ketorolac Injection
Drug: Paracetamol

First Posted Date: 2022-05-05

Last Posted Date: 2022-09-30

Lead Sponsor: National Institute of Cardiovascular Diseases, Pakistan

Target Recruit Count: 60

Registration Number: NCT05361824

Locations: 🇵🇰
National Institute of Cardiovascular Diseases, Karachi, Sindh, Pakistan

Pain Multidisciplinar Intervention in Major Trauma Patients

Recruiting

Conditions: Trauma
Chronic Pain
Psychological Trauma

Interventions: Drug: Paracetamol
Drug: Ibuprofen 600 mg
Drug: Tramadol
Drug: Morphine

First Posted Date: 2022-05-02

Last Posted Date: 2024-08-20

Lead Sponsor: Nuria Llorach-Perucho

Target Recruit Count: 80

Registration Number: NCT05355441

Locations: 🇪🇸
Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain

Breastmilk Alone or in Combination With Paracetamol for Reducing Pain

Phase 4

Conditions: Pain Control

Interventions: Drug: Paracetamol

First Posted Date: 2022-04-29

Last Posted Date: 2022-04-29

Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Target Recruit Count: 60

Registration Number: NCT05354479

Locations: 🇧🇩
BSMMu, Dhaka, Bangladesh

A Phase II Study of Vibecotamab (XmAb14045) for MRD- Positive AML and MDS After Hypomethylating Agent Failure

Phase 2

Recruiting

Conditions: AML
MDS

Interventions: Drug: Vibecotamab
Drug: Dexamethasone
Drug: Acetaminophen
Drug: Diphenhydramine

First Posted Date: 2022-03-18

Last Posted Date: 2024-11-01

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 42

Registration Number: NCT05285813

Locations: 🇺🇸
M D Anderson Cancer Center, Houston, Texas, United States

Comparative Study Between the Prophylactic Intravenous Administrations of Acetaminophen vs Dexamethasone vs Pethidine Regarding the Incidence of Shivering Induced by Single Shot Spinal Anesthesia in the Orthopedic Surgeries of the Lower Limbs

Phase 4

Active, not recruiting

Conditions: Shivering

Interventions: Drug: Pethidine
Drug: Acetaminophen
Drug: Dexamethasone

First Posted Date: 2022-03-17

Last Posted Date: 2022-09-15

Lead Sponsor: Ain Shams University

Target Recruit Count: 108

Registration Number: NCT05284409

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt

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