Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation

Phase 4

Active, not recruiting

Conditions: Liver Transplant; Complications

Interventions: Drug: Dexmedetomidine
Drug: Normal Saline

First Posted Date: 2021-09-01

Last Posted Date: 2024-01-31

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT05031026

Locations: 🇪🇬
Assiut University, Assiut, Egypt

Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery

Phase 4

Recruiting

Conditions: Delirium
Cognitive Decline
Frailty

Interventions: Drug: Dexmedetomidine
Drug: Clonidine
Drug: Natriumchlorid

First Posted Date: 2021-08-31

Last Posted Date: 2024-04-30

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 900

Registration Number: NCT05029050

Locations: 🇳🇴
Oslo University Hospital Rikshospitalet, Oslo, Norway
🇳🇴
Oslo University Hospital Ullevål, Oslo, Norway
🇳🇴
University Hospital of North Norway, Tromsø, Norway

and more 2 locations

Combined Dexmedetomidine and Glycopyrrolate Therapy

Not Applicable

Withdrawn

Conditions: Bladder Irritable

Interventions: Drug: Glycopyrrolate + dexmedetomidine
Drug: Dexmedetomidine

First Posted Date: 2021-08-19

Last Posted Date: 2021-08-19

Lead Sponsor: Kangbuk Samsung Hospital

Registration Number: NCT05013320

Effect of Dexmedetomidine on Quality of Recovery in Non-functioning Pituitary Adenoma Patients Undergoing Endoscopic Transsphenoidal Surgery

Phase 2

Conditions: Non-functioning Pituitary Adenoma

Interventions: Drug: normal saline
Drug: Dexmedetomidine

First Posted Date: 2021-08-13

Last Posted Date: 2021-08-13

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 64

Registration Number: NCT05005715

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Multimodal Versus Opioid aNalgesia in carDiAc Surgery

Phase 4

Completed

Conditions: Postoperative Delirium
Postoperative Pain

Interventions: Drug: Dexmedetomidine

First Posted Date: 2021-08-03

Last Posted Date: 2023-11-08

Lead Sponsor: University Hospital, Ghent

Target Recruit Count: 100

Registration Number: NCT04987372

Locations: 🇧🇪
Ghent University Hospital, Gent, Belgium

Th Effects of a Drug Dexmedotemidine in Regional Anesthesia in Participants Undergoing Upper Limb Surgeries

Not Applicable

Recruiting

Conditions: Supraclavicular Brachial Plexus Block

Interventions: Drug: Dexmedetomidine

First Posted Date: 2021-07-29

Last Posted Date: 2023-07-20

Lead Sponsor: Zaher Nazzal

Target Recruit Count: 70

Registration Number: NCT04981951

Locations: 🇵🇸
Zaher Nazzal, Nablus, Wes-Bank, Palestinian Territory, occupied

The Neuroprotective Effect of Dexmedetomidine Preserving Brain Functional Connectivity in Elderly Patients

Not Applicable

Recruiting

Conditions: Anesthesia
Dexmedetomidine
Aging

Interventions: Drug: Dexmedetomidine
Drug: Placebo

First Posted Date: 2021-07-22

Last Posted Date: 2024-03-28

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 50

Registration Number: NCT04973124

Locations: 🇨🇱
Pontificia Universidad Catolica de Chile, Santiago, Metropolitana, Chile

Intrathecal Dexmedetomidine Versus Transversus Abdominus Plane Block (TAP) for Postoperative Analgesia After Cesarean Section.

Not Applicable

Completed

Conditions: Pain Management in Adult Females in Child Bearing Period Aging From 20 to 45 Years Who Are Scheduled for Elective Cesarean Section

Interventions: Drug: Dexmedetomidine

First Posted Date: 2021-07-21

Last Posted Date: 2022-07-01

Lead Sponsor: Sohag University

Target Recruit Count: 60

Registration Number: NCT04969705

Locations: 🇪🇬
Sohag University Hospital, Sohag, Egypt

Dexmedetomidine Versus Triamcinolone Treatment of Carpal Tunnel Syndrome

Not Applicable

Completed

Conditions: Carpal Tunnel Syndrome
Chronic Pain

Interventions: Drug: Dexmedetomidine
Drug: Triamcinolone

First Posted Date: 2021-07-14

Last Posted Date: 2022-11-01

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT04961281

Locations: 🇪🇬
Emad Zarief Kamel Said, Assiut, Egypt

Dexmedetomidine Supplemented Analgesia and Delirium After Hip Fracture Surgery

Phase 4

Recruiting

Conditions: Elderly
Hip Fracture Surgery
Patient-controlled Analgesia
Dexmedetomidine
Postoperative Delirium

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2021-07-08

Last Posted Date: 2021-11-29

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 1440

Registration Number: NCT04955249

Locations: 🇨🇳
Peking University First Hospital, Beijing, China

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