Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Robot-assisted Pancreaticoduodenectomy: a Randomized Controlled Study

Not Applicable

Conditions: Delirium in Old Age

Interventions: Other: Saline
Drug: Dexmedetomidine

First Posted Date: 2022-03-10

Last Posted Date: 2022-06-30

Lead Sponsor: Chinese PLA General Hospital

Target Recruit Count: 300

Registration Number: NCT05274789

Locations: 🇨🇳
Beijing Tiantan Hospital,Capital Medical University, Beijing, China

Nalbuphine Versus Dexmedetomidine for Prevention of Emergence Agitation in Pediatrics

Phase 4

Conditions: Agitation

Interventions: Drug: normal Saline
Drug: Nalbuphine
Drug: Dexmedetomidine

First Posted Date: 2022-03-10

Last Posted Date: 2022-04-08

Lead Sponsor: Alexandria University

Target Recruit Count: 126

Registration Number: NCT05273671

Locations: 🇪🇬
Alexandria university, Alexandria, Egypt

Comparison Between Different Anaesthesia Techniques Protecting Renal Function in Children Undergoing Radicle Nephrectomy

Phase 2

Completed

Conditions: Renal Injury
Child, Only

Interventions: Drug: normal Saline
Drug: bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2022-03-09

Last Posted Date: 2022-03-09

Lead Sponsor: Alexandria University

Target Recruit Count: 75

Registration Number: NCT05271253

Locations: 🇪🇬
Haasan Elhoshy, Alexandria, Egypt

Nocturnal Low-dose Dexmedetomidine Infusion and Perioperative Sleep Quality

Not Applicable

Not yet recruiting

Conditions: Hip Replacement Surgery
Knee Replacement Surgery
Sleep Quality
Dexmedetomidine
Old Age

Interventions: Drug: Normal Saline
Drug: Dexmedetomidine

First Posted Date: 2022-02-18

Last Posted Date: 2022-04-20

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 432

Registration Number: NCT05246007

Locations: 🇨🇳
Beijing Hospital, Beijing, Beijing, China
🇨🇳
Peking University First Hospital, Beijing, Beijing, China

The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery

Early Phase 1

Recruiting

Conditions: Postoperative Delirium
Elderly Patients

Interventions: Drug: Normal saline
Drug: S-ketamine
Drug: Dexmedetomidine

First Posted Date: 2022-02-16

Last Posted Date: 2023-02-21

Lead Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University

Target Recruit Count: 780

Registration Number: NCT05242692

Locations: 🇨🇳
Cancer hospital and institute of Guangzhou medical university, Guangzhou, Guangdong, China

Impact of Post-ARDS Covid-19 Sedation on Persistent Neuroinflammation

Recruiting

Conditions: Severe COVID-19

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-02-10

Last Posted Date: 2024-12-24

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 72

Registration Number: NCT05233605

Locations: 🇫🇷
Anesthesy department - Hôpital Pitié Salpêtrière, Paris, France

Dexmedetomidine Different Doses as Adjuvant to Entropy-assisted General Anesthesia During Functional Endoscopy Sinus Surgery.

Not Applicable

Completed

Conditions: Pain Management
Dexmedetomidine
Anesthesia

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-02-07

Last Posted Date: 2022-11-10

Lead Sponsor: Cairo University

Target Recruit Count: 99

Registration Number: NCT05226325

Locations: 🇪🇬
Faculty of Medicine, Cairo University, Cairo, Egypt

Intravenous Versus Peribulbar Dexmedetomidine for Strabismus Surgery in Adults

Not Applicable

Completed

Conditions: Squint

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-01-31

Last Posted Date: 2023-11-15

Lead Sponsor: Aswan University Hospital

Target Recruit Count: 46

Registration Number: NCT05215158

Locations: 🇪🇬
Aswan University Hospital, Aswan, Egypt
🇪🇬
Huda Fahmy, Aswan, Egypt

Dexmedetomidine Prevents Postoperative Delirium After Deep Brain Stimulation in Patients With Parkinson's Disease

Not Applicable

Not yet recruiting

Conditions: Dexmedetomidine
Postoperative Delirium
Deep Brain Stimulation

Interventions: Drug: 0.9% saline
Drug: Dexmedetomidine

First Posted Date: 2022-01-19

Last Posted Date: 2023-06-15

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 192

Registration Number: NCT05197439

Locations: 🇨🇳
Beijing Tian Tan Hospital, Capital Medical University, Beijing, Beijing, China

Intravenous Dexmedetomidin on Postoperative Pain After Hypospadias Repair in Children

Phase 2

Conditions: Postoperative Pain

Interventions: Drug: Dexmedetomidine

First Posted Date: 2022-01-18

Last Posted Date: 2022-01-18

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT05194904

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2024. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy