Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effect of Dexmedetomidine on Postoperative Delirium After Awake Craniotomies

Not Applicable

Recruiting

Conditions: Dexmedetomidine
Awake Craniotomy
Delirium

Interventions: Drug: 0.9% saline
Drug: Dexmedetomidine

First Posted Date: 2022-01-18

Last Posted Date: 2022-11-10

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 210

Registration Number: NCT05195034

Locations: 🇨🇳
Beijing Tian Tan Hospital, Capital Medical University, Beijing, Beijing, China

Intranasal Dexmedetomidine Versus Oral Midazolam as Premedication for Propofol Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging

Phase 3

Conditions: Pediatric Sedation
MRI
Midazolam
Dexmedetomidine

Interventions: Drug: Midazolam
Drug: Dexmedetomidine

First Posted Date: 2022-01-14

Last Posted Date: 2022-03-24

Lead Sponsor: Brugmann University Hospital

Target Recruit Count: 250

Registration Number: NCT05192629

Locations: 🇧🇪
Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients

Not Applicable

Conditions: Dexmedetomidine
Postoperative Delirium

Interventions: Drug: Dexmedetomidine
Drug: 0.9% saline

First Posted Date: 2021-12-23

Last Posted Date: 2022-08-30

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 420

Registration Number: NCT05168280

Locations: 🇨🇳
Beijing Tian Tan Hospital, Capital Medical University, Beijing, Beijing, China

Dexmedetomidine Versus Magnesium Infusion in Reducing Agitations in Pediatric Patients Undergoing Adenotonsillectomy

Not Applicable

Conditions: Postoperative Agitations in Pediatric Patients

Interventions: Drug: Dexmedetomidine
Drug: Normal saline
Drug: Magnesium Sulphate

First Posted Date: 2021-12-21

Last Posted Date: 2021-12-21

Lead Sponsor: Ain Shams University

Target Recruit Count: 40

Registration Number: NCT05164627

Locations: 🇪🇬
Ain Shams University, Cairo, Egypt

Dexmedetomidine Sedation in Children Before MRI Examinations

Not Applicable

Completed

Conditions: Deep Sedation

Interventions: Drug: Dexmedetomidine

First Posted Date: 2021-12-20

Last Posted Date: 2021-12-20

Lead Sponsor: Karolinska University Hospital

Target Recruit Count: 1091

Registration Number: NCT05163704

Locations: 🇸🇪
Karolinska University Hospital, Stockholm, Sweden

Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children

Phase 1

Completed

Conditions: Emergence Delirium
Postoperative Nausea and Vomiting
Post Operative Pain

Interventions: Drug: normal Saline
Drug: Dexamethasone
Drug: Ondansetron
Drug: Dexmedetomidine

First Posted Date: 2021-11-17

Last Posted Date: 2022-04-05

Lead Sponsor: Tanta University

Target Recruit Count: 4

Registration Number: NCT05124067

Locations: 🇸🇦
Sharurah Armed Forces Hospital, Sharurah, Najran, Saudi Arabia

Efficacy and Safety of Dexmedetomidine in the Analgesic Prophylaxis , in Patients Undergoing Cardiovascular Surgery

Phase 4

Conditions: Cardiopathy
Valve Heart Disease
Coronary Artery Disease
Pain

Interventions: Drug: 0,9% Saline
Drug: Dexmedetomidine

First Posted Date: 2021-10-15

Last Posted Date: 2021-10-20

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 102

Registration Number: NCT05079672

Locations: 🇧🇷
Heart Institute (InCor), Univ. of Sao Paulo Medical School, Sao Paulo, Brazil
🇧🇷
Nova Esperança University Hospital, João Pessoa, Paraíba, Brazil