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Metoclopramide

Generic Name
Metoclopramide
Brand Names
Gimoti, Reglan
Drug Type
Small Molecule
Chemical Formula
C14H22ClN3O2
CAS Number
364-62-5
Unique Ingredient Identifier
L4YEB44I46
Background

Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.

One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route. Metoclopramide was initially approved by the FDA in 1980.

Indication

Metoclopramide in the oral tablet form is used for symptomatic treatment of both acute and recurrent diabetic gastroparesis, in addition to the treatment of gastroesophageal reflux disease (GERD) in patients who have failed to respond to traditional therapy. A nasal spray formulation is also indicated to treat adults with acute, recurrent diabetic gastroparesis.

In the intravenous injection form, it is indicated for the above conditions as well as for the prevention of vomiting that may follow emetogenic chemotherapy or nausea and vomiting after surgery. Intravenous metoclopramide facilitates intubation of the small bowel and stimulates gastric emptying and barium flow in patients who require radiological examination of the stomach or small intestine. In some cases, the delay of gastrointestinal emptying interferes with the radiographic visualization of the gastrointestinal tract, and metoclopramide is used to facilitate emptying in these cases, allowing for adequate diagnostic visualization.

Some off-label uses of metoclopramide include the management of radiation-induced nausea and vomiting, gastric bezoars, intractable hiccups, and migraine pain.

Associated Conditions
Chemotherapy-Induced Nausea and Vomiting, Diabetic Gastroparesis, Dyspepsia, Flatulence, Gastroesophageal Reflux, Gastroparesis, Hiccups, Hyperacidity, Migraine, Nausea and vomiting, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Acute, recurrent Diabetic Gastroparesis, Gastric bezoar
Associated Therapies
Facilitation of small bowel intubation therapy, Gastric emptying for radiologic procedures

Antiemetic Efficacy of Ondansetron Versus Metoclopramide

Phase 3
Conditions
Acute Gastroenteritis
Vomiting
Interventions
First Posted Date
2015-12-02
Last Posted Date
2015-12-02
Lead Sponsor
Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Target Recruit Count
250
Registration Number
NCT02619201

Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure

Not Applicable
Completed
Conditions
Colorectal Cancer Screening
Interventions
Device: PillCam® COLON 2 procedure-CONTROL
Drug: Senna tablets
Drug: PEG
Drug: Metoclopramide
Drug: Erythromycin
Drug: SUPREP oral sulfate solution
Drug: Bisacodyl
Drug: SUPREP oral sulfate solution with Gastrografin
First Posted Date
2015-06-25
Last Posted Date
2017-03-07
Lead Sponsor
Medtronic - MITG
Target Recruit Count
122
Registration Number
NCT02481219
Locations
🇺🇸

Franklin Gastroenterology, PLLC, Franklin, Tennessee, United States

🇺🇸

Indiana University Hospital, Indianapolis, Indiana, United States

🇺🇸

Pinnacle Research Group, LLC, Anniston, Alabama, United States

and more 3 locations

PEP uP Protocol in Surgical Patients

Phase 4
Terminated
Conditions
Critically Ill
Interventions
Other: PEP uP Protocol
Drug: Metoclopramide
First Posted Date
2015-06-02
Last Posted Date
2020-10-27
Lead Sponsor
Clinical Evaluation Research Unit at Kingston General Hospital
Target Recruit Count
36
Registration Number
NCT02459275
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

🇺🇸

Jamaica Hospital Medical Center, Jamaica, New York, United States

🇺🇸

Virginia Tech Carilion School of Medicine, Roanoke, Virginia, United States

and more 1 locations

Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering

First Posted Date
2015-05-12
Last Posted Date
2018-07-17
Lead Sponsor
Lagos State Health Service Commission
Target Recruit Count
130
Registration Number
NCT02441673

Anesthetics in Rhytidoplasty - A Comparison Study

First Posted Date
2015-04-07
Last Posted Date
2015-04-07
Lead Sponsor
Mercy Facial Plastic Surgery Center
Target Recruit Count
30
Registration Number
NCT02410460
Locations
🇺🇸

Mercy Facial Plastic Surgery Center, Springfield, Missouri, United States

A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.

Not Applicable
Completed
Conditions
Headache
Interventions
First Posted Date
2014-11-20
Last Posted Date
2018-04-02
Lead Sponsor
St. Louis University
Target Recruit Count
70
Registration Number
NCT02295280
Locations
🇺🇸

Saint Louis University, Saint Louis, Missouri, United States

Dopamine D-2 Antagonist Use in Poor Responders in IVF: a Randomized Controlled Trial

Not Applicable
Withdrawn
Conditions
Poor Responder
in Vitro Fertilization
Interventions
First Posted Date
2014-10-13
Last Posted Date
2022-04-11
Lead Sponsor
Mount Sinai Hospital, Canada
Registration Number
NCT02262923
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo

Phase 4
Completed
Conditions
Vomiting
Nausea
Vertigo
Interventions
First Posted Date
2014-10-01
Last Posted Date
2014-10-01
Lead Sponsor
Pamukkale University
Target Recruit Count
200
Registration Number
NCT02253524

Metoclopramide as Treatment of Clozapine-induced Hypersalivation

Phase 3
Completed
Conditions
Clozapine-induced Hypersalivation
Interventions
First Posted Date
2014-08-21
Last Posted Date
2014-08-21
Lead Sponsor
Beersheva Mental Health Center
Target Recruit Count
61
Registration Number
NCT02222220
Locations
🇮🇱

Be'er Sheva Mental Health Center,, Be'er Sheva, Israel

Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum

Phase 2
Completed
Conditions
Hyperemesis Gravidarum
Interventions
First Posted Date
2014-06-13
Last Posted Date
2023-02-14
Lead Sponsor
State University of New York at Buffalo
Target Recruit Count
31
Registration Number
NCT02163434
Locations
🇺🇸

University of Rochester, Rochester, New York, United States

🇺🇸

University at Buffalo, Buffalo, New York, United States

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