Metoclopramide
- Generic Name
- Metoclopramide
- Brand Names
- Gimoti, Reglan
- Drug Type
- Small Molecule
- Chemical Formula
- C14H22ClN3O2
- CAS Number
- 364-62-5
- Unique Ingredient Identifier
- L4YEB44I46
- Background
Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GER...
- Indication
Metoclopramide in the oral tablet form is used for symptomatic treatment of both acute and recurrent diabetic gastroparesis, in addition to the treatment of gastroesophageal reflux disease (GERD) in patients who have failed to respond to traditional therapy. A nasal spray formulation is also indicated to treat adults with acute, recurrent diabetic gastropare...
- Associated Conditions
- Chemotherapy-Induced Nausea and Vomiting, Diabetic Gastroparesis, Dyspepsia, Flatulence, Gastroesophageal Reflux, Gastroparesis, Hiccups, Hyperacidity, Migraine, Nausea and vomiting, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Acute, recurrent Diabetic Gastroparesis, Gastric bezoar
- Associated Therapies
- Facilitation of small bowel intubation therapy, Gastric emptying for radiologic procedures
Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine
- Conditions
- Interventions
- First Posted Date
- 2011-02-04
- Last Posted Date
- 2016-05-13
- Lead Sponsor
- Matthias Schwab
- Target Recruit Count
- 49
- Registration Number
- NCT01289938
- Locations
- 🇩🇪
Abteilung Klinische Pharmakologie, UKT Tübingen, Tübingen, BW, Germany
Valproate Versus Ketorolac Versus Metoclopramide
- Conditions
- Interventions
- First Posted Date
- 2010-12-29
- Last Posted Date
- 2018-06-04
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 330
- Registration Number
- NCT01267864
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Prevention of Intraoperative Nausea and Vomiting During Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2010-10-07
- Last Posted Date
- 2014-08-06
- Lead Sponsor
- Duke University
- Target Recruit Count
- 306
- Registration Number
- NCT01216410
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Opioid Effects on Swallowing and Esophageal Sphincter Pressure
- Conditions
- Interventions
- First Posted Date
- 2010-08-31
- Last Posted Date
- 2012-02-02
- Lead Sponsor
- Region Örebro County
- Target Recruit Count
- 14
- Registration Number
- NCT01191645
- Locations
- 🇸🇪
Örebro University Hospital, Örebro, Sweden
Comparison of Olanzapine and Metoclopramide For Treatment Of bReakThrough Emesis
- First Posted Date
- 2010-06-22
- Last Posted Date
- 2016-05-11
- Lead Sponsor
- Karin Jordan
- Target Recruit Count
- 23
- Registration Number
- NCT01148264
- Locations
- 🇩🇪
Martin-Luther-University Halle-Wittenberg, Department for Oncology and Hematology, Ernst-Grube-Strasse 40, Halle (Saale), Sachsen-Anhalt, Germany
Ondansetron Plus Dexamethasone With or Without Metoclopramide as Antiemetic Prophylaxis After Receiving Cisplatin
- First Posted Date
- 2010-03-26
- Last Posted Date
- 2010-12-02
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 162
- Registration Number
- NCT01093690
- Locations
- 🇹🇭
Division of medical oncology, department of medicine Siriraj Hospital, Bangkok, Thailand
Metoclopramide Versus Ketorolac for Tension-type Headache
- First Posted Date
- 2009-11-11
- Last Posted Date
- 2018-05-15
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 123
- Registration Number
- NCT01011673
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Patients With Gastroparesis
- Conditions
- Interventions
- First Posted Date
- 2009-02-18
- Last Posted Date
- 2014-06-27
- Lead Sponsor
- Evoke Pharma
- Target Recruit Count
- 287
- Registration Number
- NCT00845858
- Locations
- 🇺🇸
Impact Clinical Trials, Los Angeles, California, United States
🇺🇸Theda Oaks Endoscopy Center, San Antonio, Texas, United States
🇺🇸Consultants for Clinical Research, Cincinnati, Ohio, United States
Uncomplicated Nausea and Vomiting in the Emergency Department
- First Posted Date
- 2008-10-23
- Last Posted Date
- 2012-06-28
- Lead Sponsor
- WellSpan Health
- Target Recruit Count
- 137
- Registration Number
- NCT00778011
- Locations
- 🇺🇸
York Hospital, York, Pennsylvania, United States
Metoclopramide for Migraine: A Dose Finding Study
- First Posted Date
- 2008-05-22
- Last Posted Date
- 2018-05-31
- Lead Sponsor
- Montefiore Medical Center
- Target Recruit Count
- 349
- Registration Number
- NCT00682734
- Locations
- 🇺🇸
Montefiore Medical Center, Bronx, New York, United States
Drug Development Updates
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