Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

Dose Ranging Study of Metronidazole Vaginal Gel in the Treatment of Bacterial Vaginosis

Phase 2

Completed

Conditions: Vaginosis, Bacterial
Vaginal Infection

Interventions: Drug: GW05
Drug: Metronidazole

First Posted Date: 2010-01-25

Last Posted Date: 2011-07-01

Lead Sponsor: Graceway Pharmaceuticals, LLC

Target Recruit Count: 255

Registration Number: NCT01055106

Locations: 🇺🇸
Women's Health Research, Phoenix, Arizona, United States
🇺🇸
NEA Women's Clinic, Jonesboro, Arkansas, United States
🇺🇸
Miami Research Associates, Miami, Florida, United States

and more 17 locations

Bioavailability of Metronidazole Vaginal Gel in Healthy Subjects

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Metronidazole

First Posted Date: 2009-11-26

Last Posted Date: 2010-06-29

Lead Sponsor: Teva Pharmaceuticals USA

Target Recruit Count: 38

Registration Number: NCT01020877

Locations: 🇺🇸
Novum Pharmaceutical Research Services, Pittsburgh, Pennsylvania, United States

Bioequivalence of Metronidazole Gel, 0.75% in the Treatment of Bacterial Vaginosis

Phase 1

Completed

Conditions: Bacterial Vaginosis

Interventions: Drug: Metronidazole

First Posted Date: 2009-11-25

Last Posted Date: 2024-08-19

Lead Sponsor: Teva Pharmaceuticals USA

Target Recruit Count: 579

Registration Number: NCT01020396

Locations: 🇺🇸
Medical Affiliated Research Center, Inc., Huntsville, Alabama, United States
🇺🇸
Office of Drs. Shepard and Lugerner, PC, Washington, District of Columbia, United States
🇺🇸
Phoenix Ob-Gyn Associates, Mount Holly, New Jersey, United States

and more 33 locations

Trichomonas Vaginalis Recurrence Among HIV+ Women

Phase 4

Completed

Conditions: HIV Infections
Trichomonas Infections

Interventions: Drug: Metronidazole

First Posted Date: 2009-11-23

Last Posted Date: 2016-12-20

Lead Sponsor: Tulane University Health Sciences Center

Target Recruit Count: 270

Registration Number: NCT01018095

Locations: 🇺🇸
NOAIDS, New Orleans, Louisiana, United States
🇺🇸
HIV Outpatient Clinic, New Orleans, Louisiana, United States
🇺🇸
Crossroads Clinic, Jackson, Mississippi, United States

and more 2 locations

Comparison of 7-day and 14-day Bismuth Based Quadruple Therapy for Secondary Helicobacter Pylori Eradication

Phase 4

Completed

Conditions: Helicobacter Infection

Interventions: Drug: pantoprazole
Drug: bismuth
Drug: metronidazole
Drug: tetracycline

First Posted Date: 2009-02-11

Last Posted Date: 2016-12-06

Lead Sponsor: Asan Medical Center

Target Recruit Count: 199

Registration Number: NCT00841854

Locations: 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of

BASIC (Boric Acid, Alternate Solution for Intravaginal Colonization) Study

Phase 2

Completed

Conditions: Bacterial Vaginosis

Interventions: Drug: Placebo
Drug: Boric acid
Drug: Metronidazole

First Posted Date: 2008-11-27

Last Posted Date: 2016-10-27

Lead Sponsor: University of British Columbia

Target Recruit Count: 13

Registration Number: NCT00799214

Locations: 🇨🇦
Multicentered, family practice offices, Province-wide, British Columbia, Canada

A Randomised Controlled Trial of the Use of Topical Metronidazole (10%) to Reduce Pain After Haemorrhoidectomy

Phase 2

Completed

Conditions: Haemorrhoidectomy

Interventions: Drug: Metronidazole

First Posted Date: 2008-10-17

Last Posted Date: 2013-06-05

Lead Sponsor: S.L.A. Pharma AG

Target Recruit Count: 59

Registration Number: NCT00774722

Locations: 🇬🇧
St Marks Hospital, Harrow, United Kingdom
🇬🇧
Stepping Hill Hospital, Stockport, United Kingdom
🇬🇧
St Thomas' Hospital, Lambeth Palace Road, London, United Kingdom

and more 2 locations