Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

The Treatment of Periodontal Diseases

Phase 4

Conditions: Digestive System Disorders
Adverse Effects

Interventions: Drug: Metronidazol

First Posted Date: 2011-03-21

Last Posted Date: 2013-11-20

Lead Sponsor: University of Oslo

Target Recruit Count: 184

Registration Number: NCT01318928

Locations: 🇳🇴
Holtanklinikken, Bø i Telemark, Bø, Telemark, Norway

Treatment Study of Metronidazole to Treat Dientamoebiasis in Children

Phase 4

Completed

Conditions: Dientamoebiasis

Interventions: Drug: Metronidazole
Drug: Placebo

First Posted Date: 2011-03-15

Last Posted Date: 2013-06-26

Lead Sponsor: Statens Serum Institut

Target Recruit Count: 100

Registration Number: NCT01314976

Locations: 🇩🇰
Statens Serum Institut, Copenhagen, Denmark

Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?

Phase 3

Completed

Conditions: Anal Incontinence

Interventions: Drug: CArbosylane
Drug: Metronidazole

First Posted Date: 2011-01-12

Last Posted Date: 2015-06-03

Lead Sponsor: University Hospital, Rouen

Target Recruit Count: 16

Registration Number: NCT01275560

Locations: 🇫🇷
Physiology Unit, Hopital Charles Nicolle, 1 rue de Germont, Rouen, France

Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056)

Phase 3

Completed

Conditions: Infection
Surgical Site Infection

Interventions: Drug: ertapenem sodium
Drug: ceftriaxone sodium
Drug: placebo to metronidazole
Drug: metronidazole

First Posted Date: 2010-12-06

Last Posted Date: 2017-03-22

Lead Sponsor: Merck Sharp & Dohme LLC

Target Recruit Count: 599

Registration Number: NCT01254344

Metronidazole Pharmacokinetics (PK) in Premature Infants

Phase 1

Completed

Conditions: Serious Systemic Infections
Necrotizing Enterocolitis

Interventions: Drug: Metronidazole

First Posted Date: 2010-10-18

Last Posted Date: 2014-02-06

Lead Sponsor: Michael Cohen-Wolkowiez

Target Recruit Count: 24

Registration Number: NCT01222585

Locations: 🇺🇸
Duke University, Durham, North Carolina, United States
🇺🇸
Wesely Medical Center, Wichita, Kansas, United States
🇺🇸
CHOC Children's, Orange, California, United States

The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID)

Phase 2

Completed

Conditions: Pelvic Inflammatory Disease

Interventions: Drug: Ceftriaxone
Drug: Doxycycline
Drug: Placebo Oral Capsule
Drug: Metronidazole

First Posted Date: 2010-07-12

Last Posted Date: 2018-07-10

Lead Sponsor: Harold Wiesenfeld

Target Recruit Count: 233

Registration Number: NCT01160640

Locations: 🇺🇸
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
🇺🇸
Allegheny County Health Department Sexually Transmitted Diseases Clinic, Pittsburgh, Pennsylvania, United States
🇺🇸
UPMC Mercy Hospital, Pittsburgh, Pennsylvania, United States

Colposeptine for the Treatment of Bacterial Vaginosis

Phase 4

Terminated

Conditions: Vaginosis, Bacterial

Interventions: Drug: Colposeptine
Drug: Metronidazole

First Posted Date: 2010-06-30

Last Posted Date: 2014-02-13

Lead Sponsor: Merck KGaA, Darmstadt, Germany

Target Recruit Count: 133

Registration Number: NCT01153958

Locations: 🇨🇳
Second Hospital of West China Medical School, Sichuan University, Chengdu, China
🇨🇳
Obstetrics & Gynaecology Hospital of Fudan University, Shanghai, China
🇨🇳
Peking University Shenzhen Hospital, Shenzhen, China

and more 2 locations

A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis

Phase 2

Conditions: Bacterial Vaginosis

Interventions: Drug: Lactofiltrum + Metronidazole
Drug: Metronidazole

First Posted Date: 2010-03-18

Last Posted Date: 2010-07-21

Lead Sponsor: Avva Rus, JSC

Target Recruit Count: 90

Registration Number: NCT01089348

Locations: 🇷🇺
Kirov Regional Clinical Center of Perinatology, Kirov, Kirov oblast, Russian Federation
🇷🇺
Kirov State Medical Academy, Kirov, Kirov oblast, Russian Federation