Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

Levoﬂoxacin and Bismuth-containing Therapy Versus Quadruple Therapy as Second-line Treatment of Resistant Helicobacter Pylori Infection

Phase 4

Completed

Conditions: Cure Rate of Helicobacter Pylori Infection

Interventions: Drug: Proton pump inhibitor
Drug: Bismuth subsalicylate
Drug: Amoxicillin
Drug: Metronidazole
Drug: Levofloxacin
Drug: Tetracycline

First Posted Date: 2012-12-05

Last Posted Date: 2014-08-29

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 200

Registration Number: NCT01742429

Locations: 🇨🇳
Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, Shanghai, China

Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections

Phase 3

Completed

Conditions: Complicated Intra-abdominal Infection

Interventions: Drug: Ceftazidime-avibactam
Drug: Meropenem
Drug: metronidazole

First Posted Date: 2012-11-14

Last Posted Date: 2017-09-06

Lead Sponsor: Pfizer

Target Recruit Count: 486

Registration Number: NCT01726023

Locations: 🇻🇳
Research Site, Hochiminh, Vietnam

Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies

Not Applicable

Recruiting

Conditions: High Risk Pregnancies for Preterm Labor
Abnormal Vaginal Flora
Clindamycin Vs Metronidazole

Interventions: Drug: Clindamycin
Drug: Metronidazole

First Posted Date: 2012-11-07

Last Posted Date: 2024-06-21

Lead Sponsor: HaEmek Medical Center, Israel

Target Recruit Count: 750

Registration Number: NCT01722708

Locations: 🇮🇱
Departement of obstetric and gynecology, Poriya Medical Center, Tiberias, Israel
🇮🇱
Departement of obstetric and gynecology, HaEmek medical center, Afula, Israel

Empirical Rescue Therapies of Helicobacter Pylori Infection

Phase 4

Completed

Conditions: Functional Dyspepsia
Scarred Peptic Ulcer

Interventions: Drug: Proton Pump Inhibitor
Drug: Bismuth
Drug: Furazolidone
Drug: Tetracycline
Drug: Metronidazole
Drug: Amoxicillin

First Posted Date: 2012-08-20

Last Posted Date: 2013-06-04

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 424

Registration Number: NCT01668927

Locations: 🇨🇳
Renji Hospital, Shanghai, Shanghai, China

Effects and Safety of Metronidazole in Patients With Gastrectomy

Phase 3

Withdrawn

Conditions: Post Gastrectomy State

Interventions: Drug: Placebo
Drug: metronidazole

First Posted Date: 2012-08-07

Last Posted Date: 2020-09-21

Lead Sponsor: The Catholic University of Korea

Registration Number: NCT01658852

Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens

Phase 3

Completed

Conditions: Complicated Urinary Tract Infection
Complicated Intra-abdominal Infection

Interventions: Drug: Ceftazidime - Avibactam ( CAZ-AVI)
Drug: Best Available Therapy
Drug: Metronidazole

First Posted Date: 2012-07-19

Last Posted Date: 2017-09-29

Lead Sponsor: Pfizer

Target Recruit Count: 345

Registration Number: NCT01644643

Locations: 🇺🇦
Research Site, Zaporizhzhya, Ukraine

Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease

Phase 4

Completed

Conditions: Crohn's Disease

Interventions: Drug: Azithromycin + Metronidazole
Drug: Metronidazole

First Posted Date: 2012-05-11

Last Posted Date: 2017-08-10

Lead Sponsor: Prof. Arie Levine

Target Recruit Count: 73

Registration Number: NCT01596894

Locations: 🇮🇱
The E. Wolfson.Medical Center, Holon, Israel

Adalimumab on Preventing Post-chirurgic Recurrence on Crohn´s Disease

Phase 3

Completed

Conditions: Crohn´s Disease

Interventions: Drug: Metronidazole
Drug: Adalimumab
Drug: Azathioprine

First Posted Date: 2012-03-28

Last Posted Date: 2015-03-17

Lead Sponsor: Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa

Target Recruit Count: 86

Registration Number: NCT01564823

Locations: 🇪🇸
Hospital General Dr. Negrín, Las Palmas de Gran Canaria, Islas Canarias, Spain
🇪🇸
Hospital Reina Sofía, Córdoba, Spain
🇪🇸
Hospital Arquitecto Marcide, Ferrol, La Coruña, Spain

and more 19 locations

A Safety, Tolerability and Pharmacokinetic Study of Two Formulations of Metronidazole Versus Immediate Release Metronidazole in Patient With C. Difficile Colitis

Phase 2

Completed

Conditions: Clostridium Difficile Associated Diarrhea

Interventions: Drug: Metronidazole-DRF1
Drug: Metronidazole-DRF2
Drug: Metronidazole

First Posted Date: 2012-03-21

Last Posted Date: 2013-06-07

Lead Sponsor: Dr. Reddy's Laboratories Limited

Target Recruit Count: 60

Registration Number: NCT01559545

Locations: 🇮🇳
Apex Medicical College, Jaipur, Rajasthan, India
🇮🇳
SKS Hospital India Pvt. Ltd., Salem, Tamil Nadu, India
🇮🇳
Meenakshi Mission Hospital and Research Center, Madurai, Tamil Nadu, India

and more 9 locations

A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: CAZ-AVI
Drug: metronidazole
Drug: CAZ-AVI + metronidazole

First Posted Date: 2012-02-16

Last Posted Date: 2017-09-05

Lead Sponsor: Pfizer

Target Recruit Count: 28

Registration Number: NCT01534247

Locations: 🇺🇸
Research site, Overland Park, Kansas, United States

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