Metronidazole

Generic Name
Metronidazole
Brand Names
Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole
Drug Type
Small Molecule
Chemical Formula
C6H9N3O3
CAS Number
443-48-1
Unique Ingredient Identifier
140QMO216E
Background

Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.

Indication

Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, the heart, reproductive organs, central nervous system, and the respiratory system. Some may also be present in the bloodstream in cases of septicemia. Common infections treated by metronidazole are Bacteroides species infections, Clostridium infections, and Fusobacterium infections, as well as Peptococcus and Peptostreptococcus infections. Topical formulations of metronidazole are indicated for the treatment of inflammatory lesions of rosacea.

It is also used off-label in the treatment of Crohn's disease, as a prophylactic agent after surgery, and in the treatment of Helicobacter pylori infection. It has also been studied in the prevention of preterm births and to treat periodontal disease.

Associated Conditions
Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis
Associated Therapies
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Effectiveness of Metronidazole in Pain Control Posthemorrhoidectomy

Phase 3
Completed
Conditions
Interventions
First Posted Date
2014-12-31
Last Posted Date
2014-12-31
Lead Sponsor
Instituto Mexicano del Seguro Social
Target Recruit Count
44
Registration Number
NCT02328144
Locations
🇲🇽

Western Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico

Multi-Center Study of New Medications to Treat Vaginal Infections

Phase 3
Completed
Conditions
Interventions
First Posted Date
2014-12-04
Last Posted Date
2020-07-27
Lead Sponsor
Curatek Pharmaceuticals, LLC
Target Recruit Count
204
Registration Number
NCT02308033
Locations
🇺🇸

Women's Health CT Ob/Gyn, Bridgeport, Connecticut, United States

🇺🇸

NEA Baptist Clinic, Jonesboro, Arkansas, United States

🇺🇸

Harborview Medical Center, Seattle, Washington, United States

and more 32 locations

Multi-Center Study of New Medications to Treat Vaginal Infections

First Posted Date
2014-12-04
Last Posted Date
2020-08-04
Lead Sponsor
Curatek Pharmaceuticals, LLC
Target Recruit Count
475
Registration Number
NCT02308007
Locations
🇺🇸

Georgia Regents University, Augusta, Georgia, United States

🇺🇸

Mount Vernon CLinical Research, Sandy Springs, Georgia, United States

🇺🇸

Women's Health Practice, Champaign, Illinois, United States

and more 48 locations

IMT for Primary Clostridium Difficile Infection

First Posted Date
2014-11-25
Last Posted Date
2020-09-22
Lead Sponsor
Oslo University Hospital
Target Recruit Count
21
Registration Number
NCT02301000
Locations
🇳🇴

Diakonhjemmet Hospital, Oslo, Norway

🇳🇴

Sørlandet Hospital HF, Kristiansand, Norway

🇳🇴

Oslo University Hospital, Oslo, Norway

and more 4 locations

Alternative Antibiotic Regime in the Treatment of GAgP

First Posted Date
2014-08-22
Last Posted Date
2018-11-02
Lead Sponsor
Kocaeli University
Target Recruit Count
39
Registration Number
NCT02223702
Locations
🇹🇷

Kocaeli University Faculty of Dentistry Department of Periodontology, Kocaeli, Turkey

Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients

First Posted Date
2014-07-25
Last Posted Date
2017-05-17
Lead Sponsor
Alison Schneider
Target Recruit Count
76
Registration Number
NCT02200328
Locations
🇺🇸

Cleveland Clinic Florida, Weston, Florida, United States

Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections

First Posted Date
2014-07-10
Last Posted Date
2015-04-09
Lead Sponsor
Marjan Industria e Comercio ltda
Target Recruit Count
160
Registration Number
NCT02186145
Locations
🇧🇷

Faculty of Medicine of ABC (FMABC), Santo André, SP, Brazil

High Dose Amoxicillin Versus Tetracycline as Second-line Treatment of Resistant Helicobacter Pylori Infection

First Posted Date
2014-06-26
Last Posted Date
2016-03-01
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
312
Registration Number
NCT02175927
Locations
🇨🇳

Shanghai Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, Shanghai, China

Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication

First Posted Date
2014-06-26
Last Posted Date
2015-02-03
Lead Sponsor
Shanghai Jiao Tong University School of Medicine
Target Recruit Count
215
Registration Number
NCT02175901
Locations
🇨🇳

Shanghai Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, Shanghai, China

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