Metronidazole

Generic Name: Metronidazole

Brand Names: Flagyl, Flagystatin, Likmez, Metrocream, Metrogel, Metrolotion, Nidagel, Noritate, Nuvessa, Pylera, Rosadan, Vandazole

Drug Type: Small Molecule

Chemical Formula: C_₆H_₉N_₃O_₃

CAS Number: 443-48-1

Unique Ingredient Identifier: 140QMO216E

Background: Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections. Metronidazole has been used as an antibiotic for several decades, with added antiparasitic properties that set it ...

Indication: Metronidazole is indicated for the treatment of confirmed trichomoniasis caused by Trichomonas vaginalis (except for in the first trimester of pregnancy) and the patient's sexual partners, bacterial vaginosis, certain types of amebiasis, and various anaerobic infections. The above anaerobic infections may occur on the skin and skin structures, the abdomen, t...

Associated Conditions: Abscess Brain, Abscess, Intra-Abdominal, Anaerobic Bacterial Infection, Bacterial Endocarditis, Bacterial Peritonitis, Bacterial Septicemia, Bacterial Vaginosis (BV), Balantidiasis, Bone and Joint Infections, Central Nervous System Bacterial Infections, Empyema, Endometritis, Endomyometritis, Facial Rosacea, Giardiasis, Gynecological Infection, Helicobacter Pylori Infection, Inflammatory Papule, Inflammatory pustules, Liver Abscess, Amebic, Lower respiratory tract infection bacterial, Lung Abscess, Meningitis, Mixed Vaginal Infections, Mixed Vaginal Infections caused by Trichomonas Vaginalis, candida albicans, Periodontitis, Pneumonia, Postoperative Infections, Pouchitis, Skin and skin structure infections, Tetanus, Trichomonas Vaginitis, Tubo-ovarian abscess, Vaginal Candidiasis, Vaginitis Trichomonal, Vulvovaginitis, Acute Intestinal amebiasis, Asymptomatic Trichomoniasis, Entamoeba histolytica, Hepatic abscess, Intra-abdominal bacterial infections, Post-surgical vaginal cuff infection, Refractory Sinusitis, Symptomatic Trichomoniasis

Associated Therapies: -

Clinical Trials

LACTIN-V Study for Recurrent Bacterial Vaginosis

Phase 2

Completed

Conditions: Bacterial Vaginosis

Interventions: Biological: Lactobacillus crispatus CTV-05
Other: Placebo
Drug: Metronidazole

First Posted Date: 2016-05-09

Last Posted Date: 2020-03-04

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 228

Registration Number: NCT02766023

Locations: 🇺🇸
University of California, San Diego - Antiviral Research Center, San Diego, California, United States
🇺🇸
Washington University School of Medicine in St. Louis - Infectious Disease Clinical Research Unit, Saint Louis, Missouri, United States
🇺🇸
Cook County Health and Hospitals System - Ruth M Rothstein CORE Center, Chicago, Illinois, United States

and more 1 locations

A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions

Not Applicable

Completed

Conditions: First Trimester Abortion

Interventions: Drug: Doxycycline
Drug: Metronidazole
Drug: Azithromycin
Drug: Placebo

First Posted Date: 2016-04-29

Last Posted Date: 2022-02-11

Lead Sponsor: Medstar Health Research Institute

Target Recruit Count: 181

Registration Number: NCT02756403

Locations: 🇺🇸
MedStar Washington Hospital Center, Washington, District of Columbia, United States
🇺🇸
Planned Parenthood Metropolitan Washington, Silver Spring, Maryland, United States

Optimising Antibiotic Treatment for Sick Malnourished Children

Phase 2

Conditions: Malnutrition

Interventions: Drug: Ceftriaxone
Drug: Metronidazole

First Posted Date: 2016-04-21

Last Posted Date: 2017-07-02

Lead Sponsor: University of Oxford

Target Recruit Count: 81

Registration Number: NCT02746276

Locations: 🇰🇪
KEMRI WT Clinical Trials Facility, Kilifi, Kenya

Clarithromycin Triple Therapy Plus Bismuth for Helicobacter Pylori First-line Treatment

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Clarithromycin
Drug: Bismuth Potassium Citrate
Drug: Metronidazole

First Posted Date: 2016-04-08

Last Posted Date: 2018-06-26

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 66

Registration Number: NCT02732249

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Efficacy and Safety of the Association of Clotrimazole and Metronidazole in the Treatment of Vaginal Discharge From Different Etiologies.

Phase 3

Withdrawn

Conditions: Sexual Active Women
Vaginal Discharge

Interventions: Drug: Clotrimazole
Drug: Clotrimazole + Metronidazole
Drug: Metronidazole

First Posted Date: 2016-03-18

Last Posted Date: 2016-03-18

Lead Sponsor: Ache Laboratorios Farmaceuticos S.A.

Registration Number: NCT02713139

Fecal Microbiota Therapy for Recurrent Clostridium Difficile Infection

Phase 2

Conditions: Clostridium Difficile Infection

Interventions: Biological: Fecal Microbiota
Drug: vancomycin
Drug: Loperamide
Drug: metronidazole

First Posted Date: 2016-02-19

Last Posted Date: 2016-09-27

Lead Sponsor: Queen Elizabeth II Health Sciences Centre

Target Recruit Count: 50

Registration Number: NCT02686645

Determine the PK and Safety and Tolerability of ATM-AVI for the Treatment of cIAIs in Hospitalized Adults (REJUVENATE)

Phase 2

Completed

Conditions: Complicated Intra-Abdominal Infections, cIAIs

Interventions: Drug: ATM-AVI
Drug: Metronidazole

First Posted Date: 2016-01-14

Last Posted Date: 2020-04-02

Lead Sponsor: Pfizer

Target Recruit Count: 40

Registration Number: NCT02655419

Locations: 🇫🇷
CHU Limoges, Limoges cedex, France
🇫🇷
University Hospital C., Lille Cedex, France
🇪🇸
Hospital Universitario Son Espases, Palma de Mallorca, ISLA Baleares, Spain

and more 8 locations