Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses
- First Posted Date
- 2008-10-22
- Last Posted Date
- 2022-02-07
- Lead Sponsor
- MEDA Pharma GmbH & Co. KG
- Target Recruit Count
- 258
- Registration Number
- NCT00777127
- Locations
- 🇫🇷
Hospital Sainte Marguerite, Department for Dermatology and Venereology, Pavilion 3, First Floor, Marseille, France
🇫🇷CHU St Jacques, Department for Dermatology, Besancon Cedex, France
🇩🇪Derma Center Vechta, Vechta, Germany
An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)
- Conditions
- Interventions
- First Posted Date
- 2008-10-06
- Last Posted Date
- 2014-10-15
- Lead Sponsor
- Johnson & Johnson Taiwan Ltd
- Target Recruit Count
- 8
- Registration Number
- NCT00766402
A Multi-Center, Randomized, Double-Blind, Parallel Group Study To Compare The Efficacy And Tolerability Of Valdecoxib And Diclofenac In Patients With A Sprained Ankle
- Conditions
- Interventions
- First Posted Date
- 2008-05-05
- Last Posted Date
- 2008-05-05
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 202
- Registration Number
- NCT00671320
- Locations
- 🇵🇪
Pfizer Investigational Site, Lima, Peru
A Multicentre, Double-Blind, Double-Dummy, Randomised Study of the Analgesic Efficacy and Safety of Valdecoxib Compared to Diclofenac Sodium in Patients Undergoing Knee Arthroscopy for Anterior Cruciate Ligament (ACL) Reconstruction
- First Posted Date
- 2008-04-02
- Last Posted Date
- 2008-10-08
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 328
- Registration Number
- NCT00650598
- Locations
Pfizer Investigational Site
Randomized, Double Blind, Multicenter Study of the Safety and Efficacy of Valdecoxib 40 mg Once Daily Compared With Diclofenac 75 mg Twice Daily in Acute Low Back Pain
- First Posted Date
- 2008-04-01
- Last Posted Date
- 2008-04-10
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 340
- Registration Number
- NCT00649610
- Locations
- 🇻🇪
Pfizer Investigational Site, Caracas, Venezuela
Safety and Efficacy of Celecoxib Versus Diclofenac in the Treatment of Ankylosing Spondylitis
- First Posted Date
- 2008-04-01
- Last Posted Date
- 2008-04-10
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 458
- Registration Number
- NCT00648141
- Locations
- 🇩🇪
Pfizer Investigational Site, Winsen/Luhe, Germany
Safety And Efficacy Of Celecoxib Versus Sodium Diclofenac In The Treatment Of Acute Low Back Pain
- First Posted Date
- 2008-03-21
- Last Posted Date
- 2021-02-02
- Target Recruit Count
- 244
- Registration Number
- NCT00640432
- Locations
- 🇧🇷
Pfizer Investigational Site, São Paulo, SP, Brazil
Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain
- Conditions
- Interventions
- First Posted Date
- 2008-03-21
- Last Posted Date
- 2008-09-04
- Lead Sponsor
- Cerimon Pharmaceuticals
- Target Recruit Count
- 170
- Registration Number
- NCT00640705
- Locations
- 🇺🇸
PPD, Austin, Texas, United States
Diclofenac Patch for Treatment of Mild to Moderate Tendonitis or Bursitis
- Conditions
- Interventions
- First Posted Date
- 2008-03-21
- Last Posted Date
- 2008-08-06
- Lead Sponsor
- Cerimon Pharmaceuticals
- Target Recruit Count
- 308
- Registration Number
- NCT00640939
- Locations
- 🇺🇸
PPD, Austin, Texas, United States
Pharmacological Intervention in Diabetic Retinopathy
- Conditions
- Interventions
- First Posted Date
- 2008-02-20
- Last Posted Date
- 2010-12-29
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 87
- Registration Number
- NCT00619034
- Locations
- 🇩🇰
Department of Ophthalmology, Aarhus, Denmark
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.