Diclofenac

Generic Name
Diclofenac
Brand Names
Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
Drug Type
Small Molecule
Chemical Formula
C14H11Cl2NO2
CAS Number
15307-86-5
Unique Ingredient Identifier
144O8QL0L1
Background

Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...

Indication

Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...

Associated Conditions
Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
Associated Therapies
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Comparison of the Efficacy and Tolerability of Solaraze for 3 Versus 6 Months in Patients With Mild to Moderate Actinic Keratosis Located on the Face and Head

Phase 4
Completed
Conditions
Interventions
First Posted Date
2005-09-20
Last Posted Date
2011-08-19
Lead Sponsor
University Hospital Tuebingen
Target Recruit Count
418
Registration Number
NCT00204542
Locations
🇩🇪

Dept. of Dermatology, Freiburg, Germany

🇩🇪

Klinik fuer Dermatologie, Venerologie und Allergologie der Charite, Berlin, Germany

🇩🇪

Praxis Priv.-Doz. Dr. med. Dirschka, Wuppertal, Germany

and more 1 locations

Celecoxib Versus Diclofenac In The Treatment Of Osteoarthritis Of The Hip

Phase 4
Completed
Conditions
First Posted Date
2005-09-15
Last Posted Date
2006-12-05
Lead Sponsor
Pfizer
Target Recruit Count
250
Registration Number
NCT00174317
Locations
🇬🇧

Pfizer Investigational Site, Wigan, United Kingdom

Parecoxib in Renal Colic

Phase 3
Terminated
Conditions
First Posted Date
2005-08-31
Last Posted Date
2008-05-06
Lead Sponsor
Pfizer
Target Recruit Count
50
Registration Number
NCT00139646
Locations
🇮🇹

Pfizer Investigational Site, Siena, Italy

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