Diclofenac

Generic Name: Diclofenac

Brand Names: Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₁₁Cl_₂NO_₂

CAS Number: 15307-86-5

Unique Ingredient Identifier: 144O8QL0L1

Background: Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...

Indication: Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...

Associated Conditions: Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis

Associated Therapies: -

Clinical Trials

Comparative Clinical Trial of Lornoxicam to Diclofenac in Patients of Osteoarthritis of Knee Joint.

Not Applicable

Completed

Conditions: Osteoarthritis of Knee Joint

Interventions: Drug: Lornoxicam
Drug: Diclofenac

First Posted Date: 2010-01-25

Last Posted Date: 2010-01-25

Lead Sponsor: Government Medical College, Bhavnagar

Target Recruit Count: 40

Registration Number: NCT01055470

Locations: 🇮🇳
Sir Takthasinhji General Hospital, Bhavnagar, Gujarat, India

Symptomatic Therapy of Uncomplicated Lower Urinary Tract Infections in the Ambulatory Setting.

Phase 4

Terminated

Conditions: Urinary Tract Infections

Interventions: Drug: Norfloxacin
Drug: Diclofenac

First Posted Date: 2009-12-25

Last Posted Date: 2015-07-09

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 253

Registration Number: NCT01039545

Locations: 🇨🇭
Institute for Infectious Diseases, University of Berne, Berne, Switzerland

Efficacy of Diclofenac Potassium Versus Acetaminophen in Febrile Children With Acute Upper Respiratory Tract Infections

Phase 4

Terminated

Conditions: Fever

Interventions: Drug: Diclofenac potassium
Drug: Acetaminophen

First Posted Date: 2009-11-25

Last Posted Date: 2012-11-19

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 2

Registration Number: NCT01019980

Locations: 🇻🇪
Ciudad Hospitalaria Enrique Tejera, Valencia, Estado Carabobo, Venezuela
🇻🇪
Hospital de niños "J. M. de los Rios", Distrito Metropolitano, Caracas, Venezuela

Intravitreal Diclofenac Versus Avastin as Primary Treatment of Diffuse Diabetic Macular Edema

Phase 1

Conditions: Diffuse Diabetic Macular Edema

Interventions: Drug: Diclofenac
Drug: Bevacizumab

First Posted Date: 2009-10-22

Last Posted Date: 2010-05-04

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Registration Number: NCT00999791

Locations: 🇮🇷
Ophthalmic Research Center, Tehran, Iran, Islamic Republic of

Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Soft Tissue Injuries (TAPED)

Phase 3

Completed

Conditions: Acute Pain
Soft Tissue Injury

Interventions: Drug: Diclofenac Sodium
Drug: Matching Placebo Patch

First Posted Date: 2009-07-02

Last Posted Date: 2010-08-16

Lead Sponsor: Cerimon Pharmaceuticals

Target Recruit Count: 407

Registration Number: NCT00931866

Locations: 🇺🇸
PPD, Austin, Texas, United States

Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain

Phase 3

Completed

Conditions: Acute Pain
Ankle Sprain

Interventions: Drug: Matching Placebo Patch
Drug: Diclofenac Sodium

First Posted Date: 2009-03-25

Last Posted Date: 2010-01-28

Lead Sponsor: Cerimon Pharmaceuticals

Target Recruit Count: 219

Registration Number: NCT00869180

Locations: 🇺🇸
PPD, Austin, Texas, United States

Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip

Phase 3

Terminated

Conditions: Osteoarthritis

Interventions: Biological: tanezumab
Drug: diclofenac
Other: IV placebo

First Posted Date: 2009-03-18

Last Posted Date: 2021-02-26

Lead Sponsor: Pfizer

Target Recruit Count: 607

Registration Number: NCT00864097

Locations: 🇦🇹
Nuhr Zentrum, Senftenberg, Austria
🇦🇹
ClinPharm International GmbH, Wien, Austria
🇦🇹
Medizinische Universitaet Wien/AKH, Wien, Austria

and more 70 locations

Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy Subjects

Phase 1

Completed

Conditions: Renal Insufficiency, Chronic
Hepatic Insufficiency
Healthy

Interventions: Drug: Diclofenac Sodium
Drug: Sporanox

First Posted Date: 2008-12-09

Last Posted Date: 2009-04-30

Lead Sponsor: Javelin Pharmaceuticals

Target Recruit Count: 37

Registration Number: NCT00805090

Locations: 🇺🇸
Orlando Clinical Research Center, Orlando, Florida, United States
🇬🇧
Simbec Research, Ltd., Merthyr Tydfil, United Kingdom
🇺🇸
New Orleans Clinical Center for Research, Knoxville, Tennessee, United States

and more 1 locations