Furosemide

Generic Name: Furosemide

Brand Names: Furoscix, Lasix

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₁ClN_₂O_₅S

CAS Number: 54-31-9

Unique Ingredient Identifier: 7LXU5N7ZO5

Background: Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure. It mainly works by inhibiting electrol...

Indication: Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.
...

Associated Conditions: Acute Pulmonary Edema, Ascites, Body Fluid Retention, Edema, Hypertension, Mild to Moderate Hypertension, Chest congestion

Associated Therapies: -

Clinical Trials

Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients Recovery in the Short Term

Not Applicable

Terminated

Conditions: Oliguria
Critical Illness

Interventions: Drug: Furosemide

First Posted Date: 2016-06-15

Last Posted Date: 2019-06-14

Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Target Recruit Count: 93

Registration Number: NCT02800135

Locations: 🇫🇷
CHU de CLERMONT-FERRAND, Clermont-ferrand, France
🇫🇷
CHU de MONTPELLIER, Montpellier, France
🇫🇷
CHRU de STRASBOURG, Strasbourg, France

and more 1 locations

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure

Phase 4

Withdrawn

Conditions: Acute Heart Failure

Interventions: Drug: Sodium nitroprusside
Drug: Dobutamine
Drug: Furosemide

First Posted Date: 2016-05-10

Last Posted Date: 2018-10-31

Lead Sponsor: Montefiore Medical Center

Registration Number: NCT02767024

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Brain Relaxation With Mannitol and Furosemide

Not Applicable

Completed

Conditions: Brain Tumors

Interventions: Drug: mannitol
Drug: Furosemide
Drug: placebo

First Posted Date: 2016-03-18

Last Posted Date: 2016-03-18

Lead Sponsor: Istanbul University

Target Recruit Count: 47

Registration Number: NCT02712476

Effect of Furosemide Withdraw in Stable Chronic Heart Failure Outpatients

Phase 3

Conditions: Heart Failure

Interventions: Drug: Placebo
Drug: Furosemide

First Posted Date: 2016-02-23

Last Posted Date: 2016-02-23

Lead Sponsor: Hospital de Clinicas de Porto Alegre

Target Recruit Count: 230

Registration Number: NCT02689180

Locations: 🇧🇷
Cardiovascular Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

Short-term Efficacy of Furosemide, Isosorbide Dinitrate and Their Combination in ADHF

Not Applicable

Withdrawn

Conditions: Heart Decompensation

Interventions: Drug: Furosemide
Drug: Isosorbide Dinitrate

First Posted Date: 2016-01-08

Last Posted Date: 2023-03-21

Lead Sponsor: Chinese University of Hong Kong

Registration Number: NCT02649998

Locations: 🇭🇰
Prince of Wales Hospital, Sha Tin, NT, Hong Kong

DDI (Effect of Metformin and Furosemide on Rosuvastatin PK)

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Rosuvastatin
Drug: Metformin HCl
Drug: Furosemide

First Posted Date: 2015-10-14

Last Posted Date: 2023-11-07

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 18

Registration Number: NCT02574845

Locations: 🇩🇪
Humanpharmakologisches Zentrum Biberach, Biberach, Germany

Diuretic Vascular Filling in the Initial Management of Acute PE With Right Ventricular Dysfunction Normotensive

Phase 4

Completed

Conditions: Pulmonary Embolism

Interventions: Drug: Furosemide
Drug: NaCl 9% isotonic

First Posted Date: 2015-08-24

Last Posted Date: 2020-09-25

Lead Sponsor: Centre Hospitalier Universitaire de Nice

Target Recruit Count: 60

Registration Number: NCT02531581

Locations: 🇫🇷
CHU de Nice, Nice, France

Aerosol Inhalation Treatment for Dyspnea - Patients

Phase 1

Completed

Conditions: Dyspnea

Interventions: Drug: Furosemide
Drug: Aerosolized saline

First Posted Date: 2015-08-14

Last Posted Date: 2018-01-23

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 24

Registration Number: NCT02524054

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Single Dose of Furosemide to Improve Respiratory Distress in Moderate to Severe Bronchiolitis

Phase 2

Completed

Conditions: Bronchiolitis

Interventions: Drug: Placebo
Drug: Furosemide

First Posted Date: 2015-06-11

Last Posted Date: 2016-08-12

Lead Sponsor: Northwell Health

Target Recruit Count: 46

Registration Number: NCT02469597

Locations: 🇺🇸
Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, United States

Prevention of Severe Postpartum Hypertension

Phase 2

Withdrawn

Conditions: Hypertension

Interventions: Drug: Placebo #1
Drug: Furosemide
Drug: Placebo #2
Drug: Potassium chloride

First Posted Date: 2015-05-21

Last Posted Date: 2023-05-11

Lead Sponsor: Indiana University

Registration Number: NCT02450773

Locations: 🇺🇸
Indiana University School of Medicine, Indianapolis, Indiana, United States
🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States

Drug Development Updates

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