Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Protracted Mixture of Local Anesthetics for Major Foot and Ankle Surgery
- Conditions
- Interventions
- First Posted Date
- 2015-08-18
- Last Posted Date
- 2016-09-23
- Lead Sponsor
- Rasmus Wulff Hauritz
- Target Recruit Count
- 56
- Registration Number
- NCT02526199
- Locations
- 🇩🇰
Department of Anesthesia, Aarhus University Hospital, Aarhus, Region Midt, Denmark
Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty
- First Posted Date
- 2015-08-17
- Last Posted Date
- 2021-01-08
- Lead Sponsor
- Innocoll
- Target Recruit Count
- 319
- Registration Number
- NCT02525133
Phase 3 Study of Efficacy and Safety of the XaraColl® Bupivacaine Implant After Hernioplasty
- First Posted Date
- 2015-08-14
- Last Posted Date
- 2021-01-08
- Lead Sponsor
- Innocoll
- Target Recruit Count
- 305
- Registration Number
- NCT02523599
TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2015-08-10
- Last Posted Date
- 2019-02-08
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 87
- Registration Number
- NCT02519023
- Locations
- 🇺🇸
University of Minnesota, Minneapolis, Minnesota, United States
Postsurgical Bupivacaine Extended-release Liposome Injection for Open-reduction Internal Distal Radius Fixation.
- First Posted Date
- 2015-08-05
- Last Posted Date
- 2017-11-20
- Lead Sponsor
- University of Louisville
- Target Recruit Count
- 30
- Registration Number
- NCT02515851
Subcutaneous Wound Infiltration of Ketamine or Bupivacaine Pain Perception After Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2015-08-04
- Last Posted Date
- 2015-08-04
- Lead Sponsor
- Huseyin Aksoy
- Target Recruit Count
- 120
- Registration Number
- NCT02515422
- Locations
- 🇹🇷
Kayseri Educational and Research Hospital, Kayseri, Turkey
Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery.
- First Posted Date
- 2015-08-04
- Last Posted Date
- 2017-01-31
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 30
- Registration Number
- NCT02514980
- Locations
- 🇪🇬
Assiut university hospitals, Assiut, Assiut governorate, Egypt
Magnesium Sulfate and Bupivacaine for Rehabilitation After Distal Radius Fractures
- Conditions
- Interventions
- First Posted Date
- 2015-08-03
- Last Posted Date
- 2017-12-19
- Lead Sponsor
- Universidad Autonoma de Nuevo Leon
- Target Recruit Count
- 40
- Registration Number
- NCT02514343
- Locations
- 🇲🇽
Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico
Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia
- Conditions
- Interventions
- First Posted Date
- 2015-07-31
- Last Posted Date
- 2015-08-04
- Lead Sponsor
- Government Medical College, Haldwani
- Target Recruit Count
- 90
- Registration Number
- NCT02513433
- Locations
- 🇮🇳
Government Medical College, Haldwani, Uttarakhand, India
Parasternal Nerve Block Using Bupivacaine for Postoperative Analgesia in Children Undergoing Cardiac Surgery
- First Posted Date
- 2015-07-31
- Last Posted Date
- 2018-08-22
- Lead Sponsor
- Children's Hospitals and Clinics of Minnesota
- Target Recruit Count
- 93
- Registration Number
- NCT02512861
- Locations
- 🇺🇸
Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States
Drug Development Updates
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