Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Topical Ketamine Versus Caudal Ketamine for Postoperative Analgesia in Children Undergoing Inguinal Herniotomy
- First Posted Date
- 2015-06-03
- Last Posted Date
- 2015-10-02
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 80
- Registration Number
- NCT02462174
- Locations
- 🇪🇬
Assiut university hospitals, Assiut, Assiut governorate, Egypt
Perineural Steroids for Peripheral Nerve Blocks
- Conditions
- Interventions
- First Posted Date
- 2015-06-03
- Last Posted Date
- 2018-09-24
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 85
- Registration Number
- NCT02462148
- Locations
- 🇺🇸
Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, United States
Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients
- Conditions
- Interventions
- First Posted Date
- 2015-06-01
- Last Posted Date
- 2019-03-19
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 186
- Registration Number
- NCT02458547
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University Health System, Seoul, Korea, Republic of
Intrathecal Ketamine, Dexmedetomidine and Both With Bupivacaine for Postoperative Abdominal Cancer Surgery Pain
- Conditions
- Interventions
- First Posted Date
- 2015-05-28
- Last Posted Date
- 2015-05-28
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT02455609
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
- First Posted Date
- 2015-05-25
- Last Posted Date
- 2018-03-27
- Lead Sponsor
- Kevin King, DO
- Target Recruit Count
- 62
- Registration Number
- NCT02453321
- Locations
- 🇺🇸
University of Pittsburgh Medical Center - Passavant Hospital, Pittsburgh, Pennsylvania, United States
Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse
- First Posted Date
- 2015-05-20
- Last Posted Date
- 2017-12-08
- Lead Sponsor
- TriHealth Inc.
- Target Recruit Count
- 70
- Registration Number
- NCT02449915
- Locations
- 🇺🇸
Cincinnati Urogynecology Associates, Cincinnati, Ohio, United States
Pilot Study: Rectus Sheath Blocks for Improving Abdominal Surgery Conditions
- Conditions
- Interventions
- First Posted Date
- 2015-05-19
- Last Posted Date
- 2017-07-21
- Lead Sponsor
- University of Arkansas
- Target Recruit Count
- 6
- Registration Number
- NCT02447965
- Locations
- 🇺🇸
Univerisity of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Combined Intrathecal Morphine and Dexmedetomidine Analgesia
- Conditions
- Interventions
- First Posted Date
- 2015-05-06
- Last Posted Date
- 2015-05-06
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT02435537
Effect of Dexamethasone Dose and Route on Duration of Interscalene Block After Outpatient Shoulder Surgery
- Conditions
- Interventions
- First Posted Date
- 2015-04-27
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 280
- Registration Number
- NCT02426736
- Locations
- 🇨🇦
Pan Am Surgical Centre, Winnipeg, Manitoba, Canada
Local Injection of Local Anesthetic 24 Hours After Knee Replacement Surgery May Decrease Pain for Several More Hours
- Conditions
- Interventions
- First Posted Date
- 2015-04-20
- Last Posted Date
- 2018-01-12
- Lead Sponsor
- Brigham and Women's Hospital
- Target Recruit Count
- 50
- Registration Number
- NCT02420951
Drug Development Updates
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