Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Popliteal Block for Postoperative Pain in Knee-ankle Soft Tissue Surgery in Cerebral Palsy
- Conditions
- Interventions
- First Posted Date
- 2015-07-24
- Last Posted Date
- 2016-06-13
- Lead Sponsor
- Diskapi Teaching and Research Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02507700
- Locations
- 🇹🇷
Ministry of Health Diskapi Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
Interscalene Block With Low-dose IV vs. Perineural Dexamethasone for Shoulder Arthroscopy
- Conditions
- Interventions
- First Posted Date
- 2015-07-23
- Last Posted Date
- 2018-08-29
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 128
- Registration Number
- NCT02506660
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Pericapsular Exparel for Pain Relief in Bunionectomy and Related Procedures
- Conditions
- Interventions
- First Posted Date
- 2015-07-16
- Last Posted Date
- 2017-05-17
- Lead Sponsor
- OhioHealth
- Target Recruit Count
- 2
- Registration Number
- NCT02499575
- Locations
- 🇺🇸
Grant Medical Center, Columbus, Ohio, United States
🇺🇸Orthopedic Foot and Ankle Center, Westerville, Ohio, United States
Effect of Dexamethasone Added To Bupivacaine During Caudal Block
- First Posted Date
- 2015-07-14
- Last Posted Date
- 2015-07-15
- Lead Sponsor
- Lagos State University
- Target Recruit Count
- 96
- Registration Number
- NCT02496299
The Effects of Scalp Block With Bupivacaine Versus Levobupivacaine
- Conditions
- Interventions
- First Posted Date
- 2015-07-14
- Last Posted Date
- 2018-01-05
- Lead Sponsor
- Uludag University
- Target Recruit Count
- 90
- Registration Number
- NCT02497040
Supraclavicular Versus Interscalene Block for Shoulder Surgery
- Conditions
- Interventions
- First Posted Date
- 2015-07-01
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Tokat Gaziosmanpasa University
- Target Recruit Count
- 62
- Registration Number
- NCT02486549
- Locations
- 🇹🇷
Gaziosmanpasa University Medical School, Tokat, Turkey
Pediatric Caudal Dexmedetomidine Enhances Postoperative Analgesia of Magnesium Sulphate in Lower Abdominal Surgeries
- First Posted Date
- 2015-07-01
- Last Posted Date
- 2017-09-26
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 120
- Registration Number
- NCT02487355
- Locations
- 🇪🇬
Assiut Univeristy Hospital, Assiut, Egypt
Femoral Nerve Block Compared to Exparel in Total Knee Replacement
- Conditions
- Interventions
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2016-03-17
- Lead Sponsor
- The New England Baptist Hospital
- Target Recruit Count
- 312
- Registration Number
- NCT02473198
- Locations
- 🇺🇸
New England Baptist Hospital, Boston, Massachusetts, United States
Systemic Steroids for Peripheral Nerve Blocks
- Conditions
- Interventions
- First Posted Date
- 2015-06-08
- Last Posted Date
- 2018-08-31
- Lead Sponsor
- Wake Forest University Health Sciences
- Target Recruit Count
- 115
- Registration Number
- NCT02464176
- Locations
- 🇺🇸
Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, United States
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric
- Conditions
- Interventions
- First Posted Date
- 2015-06-04
- Last Posted Date
- 2015-06-04
- Lead Sponsor
- Universitas Diponegoro
- Target Recruit Count
- 50
- Registration Number
- NCT02463929
Drug Development Updates
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