Bupivacaine

Generic Name: Bupivacaine

Brand Names: Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₂₈N_₂O

CAS Number: 38396-39-3

Unique Ingredient Identifier: Y8335394RO

Background: Bupivacaine is a widely used local anesthetic agent.

Indication: As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.

Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.

Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.

Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.

Associated Conditions: Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions

Associated Therapies: General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy

Clinical Trials

Ultrasound Guided Femoral Nerve Block

Not Applicable

Recruiting

Conditions: Hip Fracture

Interventions: Other: ultra-sound guide
Drug: morphine
Drug: bupivacaine

First Posted Date: 2015-03-06

Last Posted Date: 2024-04-03

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 60

Registration Number: NCT02381717

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸
St. Vincent's Hospital, Worcester, Massachusetts, United States

Multimodal Pain Management Following Primary TKA

Early Phase 1

Terminated

Conditions: Pain

Interventions: Drug: Exparel
Drug: Ropivacaine cocktail (PIC)
Drug: Bupivacaine

First Posted Date: 2015-02-24

Last Posted Date: 2023-08-15

Lead Sponsor: University of Utah

Target Recruit Count: 84

Registration Number: NCT02369523

Locations: 🇺🇸
University of Utah Orthopaedic Center, Salt Lake City, Utah, United States

Hemodynamic Stability of Bupivacaine With and Without Adrenaline for Paracervical Block for Cervical Conization

Phase 4

Completed

Conditions: Cervical Intraepithelial Neoplasia

Interventions: Drug: Bupivacaine
Drug: Adrenaline

First Posted Date: 2015-02-20

Last Posted Date: 2016-08-19

Lead Sponsor: Helse Fonna

Target Recruit Count: 34

Registration Number: NCT02368054

Locations: 🇳🇴
Kirurgisk Klinikk-Anestesi, Haugesund, Rogaland, Norway

Exparel Transversus Abdominis Plane Block vs Intrathecal Analgesia In Colorectal Surgery

Not Applicable

Completed

Conditions: Conditions Requiring Colorectal Surgery

Interventions: Drug: Intrathecal hydromorphone
Drug: EXPAREL

First Posted Date: 2015-02-05

Last Posted Date: 2019-03-07

Lead Sponsor: Mayo Clinic

Target Recruit Count: 209

Registration Number: NCT02356198

Locations: 🇺🇸
Mayo Clinic Florida, Jacksonville, Florida, United States

Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section

Phase 4

Terminated

Conditions: Pain

Interventions: Drug: Intrathecal morphine injection
Drug: EXPAREL

First Posted Date: 2015-02-03

Last Posted Date: 2021-03-26

Lead Sponsor: Pacira Pharmaceuticals, Inc

Target Recruit Count: 12

Registration Number: NCT02353754

Locations: 🇺🇸
Tradition Medical Center, Port Saint Lucie, Florida, United States
🇺🇸
Saint Peter's University Hospital, New Brunswick, New Jersey, United States
🇺🇸
University Of Minnesota, Minneapolis, Minnesota, United States

and more 2 locations

Bupivacaine Supplementation For Postoperative Pain Control In Surgical Removal Of Mandibular Third Molars

Not Applicable

Conditions: Anesthesia, Local

Interventions: Other: SALINE
Drug: Bupivacaine

First Posted Date: 2015-02-03

Last Posted Date: 2015-02-03

Lead Sponsor: Cosmozone Dental Clinic

Target Recruit Count: 100

Registration Number: NCT02353676

Randomized Trial of Wound Infiltration With Extended-release Bupivacaine Before Laparoscopic or Robotic Hysterectomy

Phase 4

Completed

Conditions: Pain, Postoperative
Surgical Procedure, Unspecified

Interventions: Drug: Bupivacaine HCl
Drug: Liposomal Bupivacaine

First Posted Date: 2015-02-02

Last Posted Date: 2020-10-01

Lead Sponsor: AdventHealth

Target Recruit Count: 64

Registration Number: NCT02352922

Locations: 🇺🇸
Florida Hospital Orlando, Orlando, Florida, United States

The T REX Pilot Study: a Study to Investigate the Use of an Alternative Anaesthetic in Infants.

Phase 4

Completed

Conditions: Surgical Procedures, Operative

Interventions: Drug: Dexmedetomidine
Drug: Remifentanil
Drug: Bupivacaine
Drug: Ropivacaine

First Posted Date: 2015-02-02

Last Posted Date: 2016-10-26

Lead Sponsor: Murdoch Childrens Research Institute

Target Recruit Count: 60

Registration Number: NCT02353182

Locations: 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
🇺🇸
Texas Children's Hospital, Houston, Texas, United States
🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore

and more 3 locations