Roche Holding AG
- Country
- 🇨🇭Switzerland
- Ownership
- Public
- Established
- 1896-01-15
- Employees
- 103.6K
- Market Cap
- $270.5B
- Website
- http://www.roche.com
- Introduction
Roche is a Swiss biopharmaceutical and diagnostic company. The firm's bestselling pharmaceutical products include a variety of oncology therapies from acquired partner Genentech, and its diagnostics group was bolstered by the acquisition of Ventana in 2008. Oncology products account for 50% of pharmaceutical sales, and centralized and point-of-care diagnostics for more than half of diagnostic-related sales.
Placebo-Controlled, Single and Multiple Ascending Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986089 in Healthy Adult Subjects
- Conditions
- Healthy Adults
- Interventions
- Drug: Placebo matching with BMS-986089
- First Posted Date
- 2014-05-22
- Last Posted Date
- 2017-09-07
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 140
- Registration Number
- NCT02145234
- Locations
- 🇺🇸
Wcct Global, Llc, Cypress, California, United States
An Observational Study of BRAF Inhibitors Effectiveness in Patients With Newly Diagnosed Metastatic Melanoma
- Conditions
- Malignant Melanoma
- First Posted Date
- 2014-05-21
- Last Posted Date
- 2017-06-27
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 403
- Registration Number
- NCT02143999
- Locations
- 🇮🇹
Policlinico Ospedaliero Ss Annunziata; U.O. Di Clinica Oncologica, Chieti, Abruzzo, Italy
🇮🇹IRCCS IST. Tumori Fondaz. Pascale; S.C. Oncologia Medica,Melanoma,Immunoterapia E Terapie Innovative, Napoli, Campania, Italy
🇮🇹Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica, Bologna, Emilia-Romagna, Italy
A Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus the Combination of Trastuzumab Plus Docetaxel in Patients With HER2-positive Breast Cancer
- Conditions
- Metastatic Breast Cancer
- Interventions
- First Posted Date
- 2014-05-21
- Last Posted Date
- 2017-03-07
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 49
- Registration Number
- NCT02144012
A Study Comparing the Efficacy and Safety of Vanucizumab and FOLFOX With Bevacizumab and FOLFOX in Participants With Untreated Metastatic Colorectal Cancer
- Conditions
- Colorectal Cancer
- Interventions
- First Posted Date
- 2014-05-19
- Last Posted Date
- 2020-03-25
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 197
- Registration Number
- NCT02141295
- Locations
- 🇬🇧
Guys and St Thomas NHS Foundation Trust, Guys Hospital, London, United Kingdom
🇺🇸Fresno cCare, Fresno, California, United States
🇺🇸Oncology Hematology Care Inc, Cincinnati, Ohio, United States
A Study Comparing the Efficacy and Safety of Etrolizumab to Infliximab in Participants With Moderate to Severe Ulcerative Colitis Who Are Naïve to Tumor Necrosis Factor (TNF) Inhibitors
- Conditions
- Ulcerative Colitis
- Interventions
- First Posted Date
- 2014-05-12
- Last Posted Date
- 2021-12-03
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 397
- Registration Number
- NCT02136069
- Locations
- 🇮🇱
Chaim Sheba Medical Center; Pediatrics B North and Pediatric Endocrinology Unit, Tel Hashomer, Israel
🇭🇺Eszak-Kozep-budai Centrum, Uj Szent Janos Korhaz es Szakrendelo, Budapest, Hungary
🇭🇺Vasutegeszsegugyi Nonprofit KiemeltenKozhasznu Kft, Debrecen, Hungary
A Study Investigating the Bioavailability of a High Concentration Liquid Formulation Versus a Reference Lyophilized Formulation of Gantenerumab in Healthy Volunteers
- First Posted Date
- 2014-05-08
- Last Posted Date
- 2016-11-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 31
- Registration Number
- NCT02133937
A Study Examining Long Response in Lung Cancer Patients Treated With Tarceva (Erlotinib)
- Conditions
- Non-Small Cell Lung Cancer
- First Posted Date
- 2014-05-08
- Last Posted Date
- 2017-10-24
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 172
- Registration Number
- NCT02133508
- Locations
- 🇮🇹
A.O. Universitaria Policlinico Di Modena; Ematologia, Modena, Emilia-Romagna, Italy
🇮🇹Ospedale Provinciale Santa Maria delle Croci, Ravenna, Emilia-Romagna, Italy
🇮🇹Azienda Ospedaliera San Giuseppe Moscati, Avellino, Campania, Italy
A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer
- Conditions
- Breast Cancer
- Interventions
- First Posted Date
- 2014-05-07
- Last Posted Date
- 2021-09-17
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 401
- Registration Number
- NCT02132949
- Locations
- 🇵🇱
Wielkopolskie Centrum Onkologii; im. Marii Skłodowskiej-Curie, Poznan, Poland
🇵🇹Centro Clinico Champalimaud; Oncologia Medica, Lisboa, Portugal
🇺🇸Berkshire Medical Center, Pittsfield, Massachusetts, United States
A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer
- Conditions
- Breast Neoplasms
- Interventions
- First Posted Date
- 2014-05-06
- Last Posted Date
- 2019-07-02
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 444
- Registration Number
- NCT02131064
- Locations
- 🇺🇸
Cancer Care Assoc Med Group, Los Angeles, California, United States
🇺🇸New England Cancer Specialists, Scarborough, Maine, United States
🇺🇸Hope A Women's Cancer Center, Asheville, North Carolina, United States
Study for Participants With Ulcerative Colitis Previously Enrolled in Etrolizumab Phase II/III Studies
- First Posted Date
- 2014-04-21
- Last Posted Date
- 2024-10-23
- Lead Sponsor
- Hoffmann-La Roche
- Target Recruit Count
- 1822
- Registration Number
- NCT02118584
- Locations
- 🇩🇰
Rigshospitalet; Afdeling for Tarmsvigt og Leversygdomme, København Ø, Denmark
🇭🇺Semmelweis Egyetem; Belgyogyaszati es Hematologiai Klinika, Budapest, Hungary
🇺🇸University of Alabama Medical Center, Birmingham, Alabama, United States