Ondansetron
- Generic Name
- Ondansetron
- Brand Names
- Zofran, Zuplenz
- Drug Type
- Small Molecule
- Chemical Formula
- C18H19N3O
- CAS Number
- 99614-02-5
- Unique Ingredient Identifier
- 4AF302ESOS
- Background
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...
- Indication
In the adult patient population:
i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:
- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...
- Associated Conditions
- Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
- Associated Therapies
- -
Preoperative Oral Dexamethasone to Improve Recovery After Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-09-09
- Last Posted Date
- 2014-09-09
- Lead Sponsor
- University of Manitoba
- Target Recruit Count
- 80
- Registration Number
- NCT02234466
- Locations
- ๐จ๐ฆ
Health Science Centre, Winnipeg, Manitoba, Canada
Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2014-07-18
- Last Posted Date
- 2015-03-17
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 168
- Registration Number
- NCT02194192
- Locations
- ๐น๐ญ
Siriraj Hospital, Mahidol University, Bangkok, Thailand
Decreasing Narcotics in Advanced Pelvic Surgery
- First Posted Date
- 2014-04-10
- Last Posted Date
- 2016-08-17
- Lead Sponsor
- Hartford Hospital
- Target Recruit Count
- 138
- Registration Number
- NCT02110719
- Locations
- ๐บ๐ธ
Hartford Hosptial, Hartford, Connecticut, United States
A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC
- Conditions
- Interventions
- First Posted Date
- 2014-04-08
- Last Posted Date
- 2016-12-28
- Lead Sponsor
- Heron Therapeutics
- Target Recruit Count
- 942
- Registration Number
- NCT02106494
- Locations
- ๐บ๐ธ
Arizona Oncology Associates, PC-HAL, Pheonix, Arizona, United States
๐บ๐ธNorthern Indiana Research, South Bend, Indiana, United States
๐บ๐ธGabrail Cancer Center Research, Canton, Ohio, United States
Ondansetron for Bipolar Disorder and Alcohol Use Disorders
- Conditions
- Interventions
- First Posted Date
- 2014-03-10
- Last Posted Date
- 2021-08-24
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 70
- Registration Number
- NCT02082678
- Locations
- ๐บ๐ธ
The University of Texas Southwestern Medical Center, Dallas, Texas, United States
Efficacy of Ondansetron on Vomiting Due to Acute Gastroenteritis in Pediatric During Winter
- First Posted Date
- 2014-01-07
- Last Posted Date
- 2014-12-04
- Lead Sponsor
- Assistance Publique - Hรดpitaux de Paris
- Target Recruit Count
- 20
- Registration Number
- NCT02028910
- Locations
- ๐ซ๐ท
Vincent Gajdos, Clamart, France
Comparison of the Effect of Ondansetron and Combined Ondansetron and Betahistine on Postoperative Nausea and Vomiting After Gynecological Laparoscopy
- Conditions
- Interventions
- First Posted Date
- 2014-01-03
- Last Posted Date
- 2019-03-28
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 168
- Registration Number
- NCT02026778
- Locations
- ๐ฐ๐ท
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
Ondissolve in the Prophylaxis/Rescue of Radiation Induced Nausea and Vomiting
- First Posted Date
- 2013-12-09
- Last Posted Date
- 2018-08-16
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 30
- Registration Number
- NCT02006056
- Locations
- ๐จ๐ฆ
Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Can Ondansetron Prevent Neonatal Abstinence Syndrome (NAS) in Babies Born to Narcotic-dependent Women
- Conditions
- Interventions
- First Posted Date
- 2013-10-18
- Last Posted Date
- 2022-06-07
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 196
- Registration Number
- NCT01965704
- Locations
- ๐บ๐ธ
University of Tennessee Health Science Center, Memphis, Tennessee, United States
๐บ๐ธUniversity of Louisville, Louisville, Kentucky, United States
๐บ๐ธStanford University Medical Center, Stanford, California, United States
The Effect of Dexamethasone in Combination With Paracetamol and Ibuprofen on Postoperative Pain After Spine Surgery
- Conditions
- Interventions
- First Posted Date
- 2013-10-01
- Last Posted Date
- 2015-10-27
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 160
- Registration Number
- NCT01953978
- Locations
- ๐ฉ๐ฐ
Glostrup University Hospital, Glostrup, Denmark
Drug Development Updates
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