Ondansetron

Generic Name
Ondansetron
Brand Names
Zofran, Zuplenz
Drug Type
Small Molecule
Chemical Formula
C18H19N3O
CAS Number
99614-02-5
Unique Ingredient Identifier
4AF302ESOS
Background

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...

Indication

In the adult patient population:

i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:

- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...

Associated Conditions
Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
Associated Therapies
-
Clinical Trials
Related News

Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)

First Posted Date
2015-06-16
Last Posted Date
2024-12-16
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
187
Registration Number
NCT02473042
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for Cesarean Sections Under Regional Anesthesia

Phase 4
Completed
Conditions
PONV
Interventions
Drug: Placebo
Drug: Ondansetron
Drug: Palonosetron
First Posted Date
2015-06-10
Last Posted Date
2017-03-09
Lead Sponsor
Hospital de Base
Target Recruit Count
150
Registration Number
NCT02468323
Locations
🇧🇷

Hospital de Base do Distrito Federal, Brasilia, DF, Brazil

Trial- Dysphagia From ETT or GI Endoscopy

First Posted Date
2015-06-02
Last Posted Date
2020-03-09
Lead Sponsor
Baylor College of Medicine
Registration Number
NCT02460055

The Effects of Ondansetron on Brain Function

Phase 1
Completed
Conditions
Brain Function
Healthy Adults
Interventions
Drug: ondansetron
Drug: placebo
First Posted Date
2015-06-02
Last Posted Date
2017-04-11
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
54
Registration Number
NCT02460341
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

Scheduled Prophylactic Antiemetics for Reduction of Emesis With Doxycycline (SPARED) Trial

Not Applicable
Completed
Conditions
Drug-induced Nausea and Vomiting
Interventions
Drug: Placebo
Drug: Ondansetron
First Posted Date
2015-05-28
Last Posted Date
2020-04-16
Lead Sponsor
University of Rochester
Target Recruit Count
319
Registration Number
NCT02456662
Locations
🇺🇸

Lattimore Women's Health Practice, Rochester, New York, United States

5-HT3 Antagonists (Antiemetics) and Cardiac Safety

First Posted Date
2015-05-07
Last Posted Date
2021-05-14
Lead Sponsor
University of British Columbia
Target Recruit Count
266
Registration Number
NCT02436798
Locations
🇨🇦

Children's and Women's Health Centre of British Columbia, Vancouver, British Columbia, Canada

Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Vitrectomy Under Local Anesthesia

First Posted Date
2015-03-11
Last Posted Date
2015-03-11
Lead Sponsor
University of Catania
Target Recruit Count
1200
Registration Number
NCT02386059
Locations
🇮🇹

Federico II University, Naples, Italy

🇮🇹

Polytechnic University of Marche, Ancona, Marche, Italy

🇮🇹

University of Catania, Catania, Sicily, Italy

and more 1 locations

Pharmacogenetic Study of Ondansetron in Alcohol Use Disorder

Phase 2
Completed
Conditions
Alcohol Use Disorder
Interventions
Drug: Placebo
Drug: Ondansetron
First Posted Date
2015-02-03
Last Posted Date
2022-01-14
Lead Sponsor
University of Maryland, Baltimore
Target Recruit Count
293
Registration Number
NCT02354703
Locations
🇺🇸

University of Pennsylvania Treatment Research Center, Philadelphia, Pennsylvania, United States

🇺🇸

MPRC, Baltimore, Maryland, United States

🇺🇸

Philadelphia VAMC, Philadelphia, Pennsylvania, United States

Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy

First Posted Date
2014-12-31
Last Posted Date
2018-11-30
Lead Sponsor
B.P. Koirala Institute of Health Sciences
Target Recruit Count
90
Registration Number
NCT02327923
Locations
🇳🇵

BP Koirala Institute of Health Sciences, Dharan, Sunsari District, Nepal

Ondansetron's Opposite Effect on Postoperative Analgesia of Acetaminophen

Phase 4
Completed
Conditions
Postoperative Pain
Interventions
Drug: isotonic
Drug: ondansetron
First Posted Date
2014-11-20
Last Posted Date
2015-03-13
Lead Sponsor
Mustafa Kemal University
Target Recruit Count
80
Registration Number
NCT02296333
Locations
🇹🇷

Mustafa Kemal University Medicine Faculty, Hatay, Turkey

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