Ketamine
- Generic Name
- Ketamine
- Brand Names
- Ketalar
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 6740-88-1
- Unique Ingredient Identifier
- 690G0D6V8H
- Background
Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...
- Indication
Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...
- Associated Conditions
- -
- Associated Therapies
- General Anesthesia, Induction and Maintenance of General Anesthesia
Efficacy of Low Analgesic Doses of Ketamine Associated With Opioids in Refractory Cancer Pain Treatment
- First Posted Date
- 2011-03-30
- Last Posted Date
- 2013-08-07
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 24
- Registration Number
- NCT01326325
- Locations
- 🇫🇷
Center of Evaluation and Treatment of the pain - Saint-Antoine Hospital, Paris, Ile de France, France
Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia
- Conditions
- Interventions
- First Posted Date
- 2011-03-29
- Last Posted Date
- 2016-01-14
- Lead Sponsor
- Julia Finkel
- Target Recruit Count
- 54
- Registration Number
- NCT01325493
- Locations
- 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States
Epidural Levobupivacaine-sufentanil Versus Epidural Levobupivacaine and Intravenous Ketamine
- First Posted Date
- 2011-03-22
- Last Posted Date
- 2016-09-23
- Lead Sponsor
- Hopital Foch
- Target Recruit Count
- 2
- Registration Number
- NCT01320475
- Locations
- 🇫🇷
Hopital Foch, Suresnes, France
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
- Conditions
- Interventions
- First Posted Date
- 2011-03-07
- Last Posted Date
- 2013-08-30
- Lead Sponsor
- James Murrough
- Target Recruit Count
- 3
- Registration Number
- NCT01309581
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York City, New York, United States
The Use of Ketamine as an Anaesthetic During Electroconvulsive Therapy
- First Posted Date
- 2011-03-02
- Last Posted Date
- 2016-09-08
- Lead Sponsor
- University of Aberdeen
- Target Recruit Count
- 40
- Registration Number
- NCT01306760
- Locations
- 🇬🇧
Royal Cornhill Hospital, NHS Grampian, Aberdeen, United Kingdom
Intranasal Ketamine in Treatment-Resistant Depression
- First Posted Date
- 2011-02-25
- Last Posted Date
- 2017-02-08
- Lead Sponsor
- James Murrough
- Target Recruit Count
- 20
- Registration Number
- NCT01304147
- Locations
- 🇺🇸
Icahn School of Medicine at Mount Sinai, New York City, New York, United States
Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia
- Conditions
- Interventions
- First Posted Date
- 2011-02-23
- Last Posted Date
- 2014-11-10
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 60
- Registration Number
- NCT01301079
- Locations
- 🇧🇷
Federal University of São Paulo, São Paulo, Brazil
Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention
- First Posted Date
- 2011-02-15
- Last Posted Date
- 2019-09-04
- Lead Sponsor
- Imperial College Healthcare NHS Trust
- Target Recruit Count
- 77
- Registration Number
- NCT01296347
- Locations
- 🇬🇧
Imperial College Healthcare NHS Trust, London, United Kingdom
N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression
- Conditions
- Interventions
- First Posted Date
- 2010-12-15
- Last Posted Date
- 2017-05-22
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 17
- Registration Number
- NCT01260649
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Prevention of Persistent Postsurgical Pain After Thoracotomy
- First Posted Date
- 2010-11-19
- Last Posted Date
- 2015-03-23
- Lead Sponsor
- Hospital Clinic of Barcelona
- Target Recruit Count
- 104
- Registration Number
- NCT01243801
- Locations
- 🇪🇸
Department Anesthesia. Hospital Clinic Barcelona, Barcelona, Spain
🇪🇸Hospital Clinic, Barcelona, Spain
Drug Development Updates
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