Ketamine
- Generic Name
- Ketamine
- Brand Names
- Ketalar
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16ClNO
- CAS Number
- 6740-88-1
- Unique Ingredient Identifier
- 690G0D6V8H
- Background
Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...
- Indication
Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...
- Associated Conditions
- -
- Associated Therapies
- General Anesthesia, Induction and Maintenance of General Anesthesia
A Blinded, Four-Way Crossover in Healthy Subjects to Assess EEG After Administration of Ketamine, Placebo and AZD6765
- First Posted Date
- 2010-05-26
- Last Posted Date
- 2014-10-13
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 36
- Registration Number
- NCT01130909
- Locations
- 🇫🇷
Research Site, Rouffach, France
Combined Ketamine/Propofol for Emergency Department Procedural Sedation
- Conditions
- Interventions
- First Posted Date
- 2010-05-20
- Last Posted Date
- 2023-04-24
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 107
- Registration Number
- NCT01126957
- Locations
- 🇺🇸
University of Missouri - Columbia dept. of Emergency Medicine, Columbia, Missouri, United States
Ketamine Challenge Study With JNJ-40411813
- Conditions
- Interventions
- First Posted Date
- 2010-04-12
- Last Posted Date
- 2014-04-08
- Target Recruit Count
- 40
- Registration Number
- NCT01101659
Immunomodulatory Properties of Ketamine in Sepsis
- First Posted Date
- 2010-03-18
- Last Posted Date
- 2017-08-21
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 19
- Registration Number
- NCT01089361
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Escalating Ketamine Doses and Pre-emption
- First Posted Date
- 2010-02-17
- Last Posted Date
- 2010-02-17
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Target Recruit Count
- 120
- Registration Number
- NCT01070108
- Locations
- 🇮🇱
Tel Aviv Medical Center, Tel Aviv, Israel
A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
- First Posted Date
- 2010-02-09
- Last Posted Date
- 2013-05-03
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 85
- Registration Number
- NCT01065350
- Locations
- 🇺🇸
Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States
Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects
- First Posted Date
- 2010-01-12
- Last Posted Date
- 2014-10-13
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 128
- Registration Number
- NCT01046630
- Locations
- 🇬🇧
Research Site, Oxford, United Kingdom
Preemptive Low-dose Epidural Ketamine for Preventing Chronic Post-thoracotomy Pain
- Conditions
- Interventions
- First Posted Date
- 2009-11-20
- Last Posted Date
- 2009-11-20
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 209
- Registration Number
- NCT01017393
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Dexmedetomidine Sedation With Third Molar Surgery
- Conditions
- Interventions
- First Posted Date
- 2009-11-20
- Last Posted Date
- 2013-06-17
- Lead Sponsor
- University of North Carolina, Chapel Hill
- Target Recruit Count
- 18
- Registration Number
- NCT01017237
- Locations
- 🇺🇸
University of North Carolina School of Dentistry, Chapel Hill, North Carolina, United States
Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)
- First Posted Date
- 2009-10-19
- Last Posted Date
- 2012-04-02
- Lead Sponsor
- Hennepin Healthcare Research Institute
- Target Recruit Count
- 100
- Registration Number
- NCT00997321
- Locations
- 🇺🇸
Hennepin County Medical Center, Minneapolis, Minnesota, United States
Drug Development Updates
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